{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:07:01Z","timestamp":1792678021065,"version":"4.5.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,9,22]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Right ventricular (\n              <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>\n              ) diastolic function has been associated with outcomes for patients with pulmonary hypertension; however, the relationship between biomechanics and hemodynamics in the right ventricle has not been studied.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Rat models of\n              <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>\n              pressure overload were obtained via pulmonary artery banding (\n              <jats:styled-content style=\"fixed-case\">PAB<\/jats:styled-content>\n              ; control, n=7;\n              <jats:styled-content style=\"fixed-case\">PAB,<\/jats:styled-content>\n              n=5). At 3\u00a0weeks after banding,\n              <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>\n              hemodynamics were measured using a conductance catheter. Biaxial mechanical properties of the\n              <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>\n              free wall myocardium were obtained to extrapolate longitudinal and circumferential elastic modulus in low and high strain regions (E\n              <jats:sub>1<\/jats:sub>\n              and E\n              <jats:sub>2<\/jats:sub>\n              , respectively). Hemodynamic analysis revealed significantly increased end\u2010diastolic elastance (E\n              <jats:sub>ed<\/jats:sub>\n              ) in\n              <jats:styled-content style=\"fixed-case\">PAB<\/jats:styled-content>\n              (control: 55.1 mm\u00a0Hg\/mL [interquartile range: 44.7\u201385.4 mm\u00a0Hg\/mL];\n              <jats:styled-content style=\"fixed-case\">PAB<\/jats:styled-content>\n              : 146.6 mm\u00a0Hg\/mL [interquartile range: 105.8\u2013155.0 mm\u00a0Hg\/mL];\n              <jats:italic>P<\/jats:italic>\n              =0.010). Longitudinal E\n              <jats:sub>1<\/jats:sub>\n              was increased in\n              <jats:styled-content style=\"fixed-case\">PAB<\/jats:styled-content>\n              (control: 7.2 kPa [interquartile range: 6.7\u201318.1 kPa];\n              <jats:styled-content style=\"fixed-case\">PAB<\/jats:styled-content>\n              : 34.2 kPa [interquartile range: 18.1\u201344.6 kPa];\n              <jats:italic>P<\/jats:italic>\n              =0.018), whereas there were no significant changes in longitudinal E\n              <jats:sub>2<\/jats:sub>\n              or circumferential E\n              <jats:sub>1<\/jats:sub>\n              and E\n              <jats:sub>2<\/jats:sub>\n              . Last, wall stress was calculated from hemodynamic data by modeling the right ventricle as a sphere:\n              <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" overflow=\"scroll\">\n                <mml:mfenced close=\")\" open=\"(\" separators=\"\">\n                  <mml:mtext>stress<\/mml:mtext>\n                  <mml:mo>=<\/mml:mo>\n                  <mml:mfrac>\n                    <mml:mrow>\n                      <mml:mtext>Pressure<\/mml:mtext>\n                      <mml:mo>\u00d7<\/mml:mo>\n                      <mml:mtext>radius<\/mml:mtext>\n                    <\/mml:mrow>\n                    <mml:mrow>\n                      <mml:mn>2<\/mml:mn>\n                      <mml:mo>\u00d7<\/mml:mo>\n                      <mml:mtext>thickness<\/mml:mtext>\n                    <\/mml:mrow>\n                  <\/mml:mfrac>\n                <\/mml:mfenced>\n              <\/mml:math>\n              .\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>\n              pressure overload in\n              <jats:styled-content style=\"fixed-case\">PAB<\/jats:styled-content>\n              rats resulted in an increase in diastolic myocardial stiffness reflected both hemodynamically, by an increase in E\n              <jats:sub>ed<\/jats:sub>\n              , and biomechanically, by an increase in longitudinal E\n              <jats:sub>1<\/jats:sub>\n              . Modest increases in tissue biomechanical stiffness are associated with large increases in E\n              <jats:sub>ed<\/jats:sub>\n              . Hemodynamic measurements of\n              <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>\n              diastolic function can be used to predict biomechanical changes in the myocardium.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.117.006084","type":"journal-article","created":{"date-parts":[[2017,9,13]],"date-time":"2017-09-13T00:10:49Z","timestamp":1505261449000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":55,"title":["Biomechanical and Hemodynamic Measures of Right Ventricular Diastolic Function: Translating Tissue Biomechanics to Clinical Relevance"],"prefix":"10.1161","volume":"6","author":[{"given":"Sae","family":"Jang","sequence":"first","affiliation":[{"name":"School of Medicine, University of Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca R.","family":"Vanderpool","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Arizona, Tucson, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Avazmohammadi","sequence":"additional","affiliation":[{"name":"Institute for Computational Engineering and Sciences, University of Texas at Austin, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Lapshin","sequence":"additional","affiliation":[{"name":"School of Arts &amp; Sciences, University of Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy N.","family":"Bachman","sequence":"additional","affiliation":[{"name":"Vascular Medicine Institute, University of Pittsburgh, PA"},{"name":"Department of Bioengineering, University of Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Sacks","sequence":"additional","affiliation":[{"name":"Institute for Computational Engineering and Sciences, University of Texas at Austin, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc A.","family":"Simon","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Pittsburgh, PA"},{"name":"Heart and Vascular Institute, University of Pittsburgh, PA"},{"name":"Vascular Medicine Institute, University of Pittsburgh, PA"},{"name":"Department of Bioengineering, University of Pittsburgh, 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