{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T03:46:20Z","timestamp":1785296780393,"version":"3.55.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In this study, we sought to investigate the 2\u2010year prognostic impact of B\u2010type natriuretic peptide (\n              <jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content>\n              ) levels at discharge, following transcatheter aortic valve replacement.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We enrolled 1094 consecutive patients who underwent transcatheter aortic valve replacement between 2013 and 2016. Study patients were stratified into 2 groups according to survival classification and regression tree analysis (high versus low\n              <jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content>\n              groups). We evaluated the impact of high\n              <jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content>\n              on 2\u2010year mortality compared with that of low\n              <jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content>\n              using a multivariable Cox model, and assessed whether this stratification would improve predictive accuracy for determining 2\u2010year mortality by assessing time\u2010dependent net reclassification improvement and integrated discrimination improvement. The median age of patients was 85\u00a0years (quartile 82\u201388), and 29.2% of the study population were men. The median Society of Thoracic Surgeons score was 6.8 (4.7\u20139.5), and\n              <jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content>\n              at discharge was 186 (93\u2013378) pg\/mL. All\u2010cause mortality following discharge was 7.9% (95% CI, 5.8\u20139.9%) at 1\u00a0year and 15.4% (95% CI, 11.6\u201319.0%) at 2\u00a0years. The survival classification and regression tree analysis revealed that the discriminating\n              <jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content>\n              level to discern 2\u2010year mortality was 202\u00a0pg\/mL, and that elevated\n              <jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content>\n              had a statistically significant impact on outcomes, with an adjusted hazard ratio of 2.28 (1.36\u20133.82,\n              <jats:italic>P<\/jats:italic>\n              =0.002). The time\u2010dependent net reclassification improvement (\n              <jats:italic>P<\/jats:italic>\n              =0.047) and integrated discrimination improvement (\n              <jats:italic>P<\/jats:italic>\n              =0.029) analysis revealed that the incorporation of\n              <jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content>\n              stratification with other clinical variables significantly improved predictive accuracy for 2\u2010year mortality.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Elevation of\n              <jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content>\n              at discharge is associated with 2\u2010year mortality after transcatheter aortic valve replacement.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.117.006112","type":"journal-article","created":{"date-parts":[[2017,7,15]],"date-time":"2017-07-15T00:10:18Z","timestamp":1500077418000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":39,"title":["Elevation of B\u2010Type Natriuretic Peptide at Discharge is Associated With 2\u2010Year Mortality After Transcatheter Aortic Valve Replacement in Patients With Severe Aortic Stenosis: Insights From a Multicenter Prospective OCEAN\u2010TAVI (Optimized Transcatheter Valvular Intervention\u2013Transcatheter Aortic Valve Implantation) Registry"],"prefix":"10.1161","volume":"6","author":[{"given":"Kazuki","family":"Mizutani","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Iwata","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Yoshiyama","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Naganuma","sequence":"additional","affiliation":[{"name":"Department of Cardiology, New Tokyo Hospital, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Futoshi","family":"Yamanaka","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shonan Kamakura General Hospital, Kamakura, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Higashimori","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kishiwada Tokushukai Hospital, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Tada","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sendai Kousei Hospital, Miyagi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Takagi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ogaki Municipal Hospital, Gifu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoharu","family":"Araki","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Saiseikai Yokohama City Eastern Hospital, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ueno","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, University of Toyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Tabata","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Tokyo Bay Urayasu\u2010Ichikawa Medical Center, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Shirai","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kokura Memorial Hospital, Kitakyusyu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Teikyo University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Toyohashi Heart Center, Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Hayashida","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Keio University School of Medicine, Tokyo, 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