{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T08:20:24Z","timestamp":1787905224430,"version":"build-2784847793"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,7]]},"abstract":"\n Background<\/jats:title>\n \n Obstructive sleep apnea (\n OSA<\/jats:styled-content>\n ) is an independent risk factor for many cardiovascular conditions such as coronary artery disease, myocardial infarction, systemic hypertension, pulmonary hypertension, and stroke. However, the association of\n OSA<\/jats:styled-content>\n with outcomes in patients hospitalized for\n ST<\/jats:styled-content>\n \u2010elevation myocardial infarction remains controversial.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We used the nation\u2010wide inpatient sample between 2003 and 2011 to identify patients with a primary discharge diagnosis of\n ST<\/jats:styled-content>\n \u2010elevation myocardial infarction and then used the International Classification of Diseases, Clinical Modification code 327.23 to identify a group of patients with\n OSA<\/jats:styled-content>\n . The primary outcome of interest was in\u2010hospital mortality, and secondary outcomes were in\u2010hospital cardiac arrest, length of stay and hospital charges. Our cohort included 1\u00a0850\u00a0625 patients with\n ST<\/jats:styled-content>\n \u2010elevation myocardial infarction, of which 1.3% (24\u00a0623) had documented\n OSA<\/jats:styled-content>\n .\n OSA<\/jats:styled-content>\n patients were younger and more likely to be male, smokers, and have chronic pulmonary disease, depression, hypertension, known history of coronary artery disease, dyslipidemia, obesity, and renal failure (\n P<\/jats:italic>\n <0.001 for all). Patients with\n OSA<\/jats:styled-content>\n had significantly decreased in\u2010hospital mortality (adjusted odds ratio, 0.78 [95%\n CI<\/jats:styled-content>\n , 0.73\u20130.84]), longer hospital stay (5.00\u00b14.68 versus 4.85\u00b15.96\u00a0days), and incurred greater hospital charges ($79\u00a0460.12\u00b170\u00a0621.91 versus $62\u00a0889.91\u00b169\u00a0124.15). There was no difference in incidence of in\u2010hospital cardiac arrest (adjusted odds ratio, 0.93 [95%\n CI<\/jats:styled-content>\n , 0.84\u20131.03]) between these 2 groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n ST<\/jats:styled-content>\n \u2010elevation myocardial infarction patients with recognized\n OSA<\/jats:styled-content>\n had significantly decreased mortality compared with patients without\n OSA<\/jats:styled-content>\n . Although patients with\n OSA<\/jats:styled-content>\n had longer hospital stays and incurred greater hospital charges, there was no difference in incidence of in\u2010hospital cardiac arrest.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.117.006133","type":"journal-article","created":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T00:10:36Z","timestamp":1500595836000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":38,"title":["Recognized Obstructive Sleep Apnea is Associated With Improved In\u2010Hospital Outcomes After ST Elevation Myocardial Infarction"],"prefix":"10.1161","volume":"6","author":[{"given":"Divyanshu","family":"Mohananey","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro A.","family":"Villablanca","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases, Montefiore Medical Center\/Albert Einstein College of Medicine, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanush","family":"Gupta","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases, Montefiore Medical Center\/Albert Einstein College of Medicine, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahil","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, St. Lukes University Health Network, Bethlehem, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Faulx","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venugopal","family":"Menon","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir R.","family":"Kapadia","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian P.","family":"Griffin","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen G.","family":"Ellis","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milind Y.","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-1544"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000006952"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.1999.14a30.x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.294.6563.16"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.14.1829"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-010-0411-y"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.1464"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2006.03.012"},{"key":"e_1_3_3_10_2","first-page":"621","article-title":"Myocardial infarct size\u2010limiting effect of chronic hypoxia persists for five weeks of normoxic recovery","volume":"53","author":"Neckar J","year":"2004","unstructured":"Neckar J, Ostadal B, Kolar F. 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Physiol Res. 2004;53:621\u2013628.","journal-title":"Physiol Res"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-012-0770-7"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-013-0991-2"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2009.00754.x"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2010.08.030"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2016.06.019"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-2905"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.1.55"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv347"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00600-2"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.2147\/HP.S103091"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1124\/pr.107.06002"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-011-0159-y"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-1136"},{"key":"e_1_3_3_24_2","first-page":"908582","article-title":"Effects of obstructive sleep apnea on cardiac function and clinical outcomes in Chinese patients with ST\u2010elevation myocardial infarction","volume":"2014","author":"Liu B","year":"2014","unstructured":"Liu B, Guo R, Zhou S, Xie S, Wang K, Xu Y. 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