{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T21:08:45Z","timestamp":1789420125321,"version":"build-2803163510"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,10,11]]},"abstract":"\n Background<\/jats:title>\n \n Pregnant women with pulmonary hypertension (\n PH<\/jats:styled-content>\n ) are at risk for adverse cardiac outcomes, particularly at the time of labor and delivery. The purpose of this study is to define the impact of\n PH<\/jats:styled-content>\n on pregnancy outcomes and the risk of major adverse cardiac events (\n MACE<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n The National Inpatient Sample was screened for hospital admissions of women delivering during the years 2003 to 2012. The primary outcome was\n MACE<\/jats:styled-content>\n , a composite of death, cardiac arrest, cardiogenic shock, myocardial infarction, respiratory failure, arrhythmia, stroke, and embolic event. Data on 1519 patients with\n PH<\/jats:styled-content>\n and 6\u00a0757\u00a0582 without heart disease or\n PH<\/jats:styled-content>\n were available. There were 59.6% with isolated\n PH<\/jats:styled-content>\n ; 10.7% with\n PH<\/jats:styled-content>\n and congenital heart disease; 18.1% with\n PH<\/jats:styled-content>\n and valvular heart disease; 3% with\n PH<\/jats:styled-content>\n and valvular heart disease and congenital heart disease; 6.6%\n PH<\/jats:styled-content>\n and cardiomyopathy; and 1.9% with\n PH<\/jats:styled-content>\n and cardiomyopathy and valvular heart disease. Compared with women without heart disease or\n PH<\/jats:styled-content>\n , women with\n PH<\/jats:styled-content>\n experienced significantly higher\n MACE<\/jats:styled-content>\n (24.8 versus 0.4%,\n P<\/jats:italic>\n <0.0001). Among the subsets of women with\n PH<\/jats:styled-content>\n , the highest\n MACE<\/jats:styled-content>\n was noted in women with the combination of\n PH<\/jats:styled-content>\n and cardiomyopathy and valvular heart disease, and\n PH<\/jats:styled-content>\n and cardiomyopathy, primarily because of heart failure and arrhythmia. Women with\n PH<\/jats:styled-content>\n were significantly more likely to experience eclampsia syndromes, preterm delivery, and intrauterine fetal demise (\n P<\/jats:italic>\n <0.0001 for all).\n PH<\/jats:styled-content>\n subtype was significantly associated with\n MACE<\/jats:styled-content>\n in multivariable analysis (\n P<\/jats:italic>\n <0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In a contemporary data set of pregnant women in the United States,\n PH<\/jats:styled-content>\n was associated with an increase in\n MACE<\/jats:styled-content>\n during the hospitalization for delivery, with an exceptionally elevated risk among women with associated cardiomyopathy.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.117.006144","type":"journal-article","created":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T20:10:34Z","timestamp":1508875834000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":72,"title":["Pulmonary Hypertension and Pregnancy Outcomes: Insights From the National Inpatient Sample"],"prefix":"10.1161","volume":"6","author":[{"given":"Erin","family":"Thomas","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Medicine, State University of New York Stony Brook University Medical Center, Stony Brook, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Family, Population and Preventive Medicine, Stony Brook University Medical Center, Stony Brook, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio V.","family":"Lima","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Medicine, State University of New York Stony Brook University Medical Center, Stony Brook, NY"},{"name":"Department of Medicine, Brown University Rhode Island Hospital, Providence, RI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Stergiopoulos","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Medicine, State University of New York Stony Brook University Medical Center, Stony Brook, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn597"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.594"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00162-4"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000458"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr218"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/682230"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12471-011-0219-9"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.134.suppl_1.11980"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc3001.093437"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2014.10.008"},{"key":"e_1_3_5_12_2","unstructured":"Clinical Classifications Software (CCS) for ICD\u20109\u2010CM. 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