{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T13:11:29Z","timestamp":1788786689427,"version":"build-2803163510"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,7]]},"abstract":"\n Background<\/jats:title>\n \n Bradycardia on presentation is frequently observed in patients with right coronary artery\n ST<\/jats:styled-content>\n \u2010segment elevation myocardial infarction, but it is largely unknown whether it predicts poor angiographic or clinical outcomes in that patient population. We sought to determine the prognostic implications of admission heart rate (\n AHR<\/jats:styled-content>\n ) in patients with\n ST<\/jats:styled-content>\n \u2010segment elevation myocardial infarction and a right coronary artery culprit lesion.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We analyzed 1460 patients with\n ST<\/jats:styled-content>\n \u2010segment elevation myocardial infarction and a right coronary artery culprit lesion enrolled in the randomized HORIZONS\u2010AMI (Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction) trial who underwent primary percutaneous coronary intervention. Patients presenting with high\u2010grade atrioventricular block were excluded. Outcomes were examined according to\n AHR<\/jats:styled-content>\n range (\n AHR<\/jats:styled-content>\n <60, 61\u201379, 80\u201399, and \u2265100\u00a0beats per minute). Baseline and procedural characteristics did not vary significantly with\n AHR<\/jats:styled-content>\n except for a more frequent history of diabetes mellitus, longer symptom\u2010to\u2010balloon time, more frequent cardiogenic shock, and less frequent restoration of thrombolysis in myocardial infarction 3 flow in patients with admission tachycardia (\n AHR<\/jats:styled-content>\n >100\u00a0beats per minute). Angiographic analysis showed no significant association between\n AHR<\/jats:styled-content>\n and lesion location or complexity. On multivariate analysis, admission bradycardia (\n AHR<\/jats:styled-content>\n <60\u00a0beats per minute) was not associated with increased 1\u2010year mortality (hazard ratio 1.33; 95%\n CI<\/jats:styled-content>\n 0.41\u20134.34,\n P<\/jats:italic>\n =0.64) or major adverse cardiac events (hazard ratio 1.08; 95%\n CI<\/jats:styled-content>\n 0.62\u20131.88,\n P<\/jats:italic>\n =0.78), whereas admission tachycardia was a strong independent predictor of mortality (hazard ratio 5.02; 95%\n CI<\/jats:styled-content>\n 1.95\u201312.88,\n P<\/jats:italic>\n =0.0008) and major adverse cardiac events (hazard ratio 2.20; 95%\n CI<\/jats:styled-content>\n 1.29\u20133.75,\n P<\/jats:italic>\n =0.0004).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In patients with\n ST<\/jats:styled-content>\n \u2010segment elevation myocardial infarction and a right coronary artery culprit lesion undergoing primary percutaneous coronary intervention, admission bradycardia was not associated with increased mortality or major adverse cardiac events at 1\u00a0year.\n <\/jats:p>\n <\/jats:sec>\n \n Clinical Trial Registration<\/jats:title>\n \n URL<\/jats:styled-content>\n :\n https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n . Unique identifier:\n NCT<\/jats:styled-content>\n 00433966.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.117.006181","type":"journal-article","created":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T00:10:18Z","timestamp":1500509418000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Correlation of Admission Heart Rate With Angiographic and Clinical Outcomes in Patients With Right Coronary Artery ST\u2010Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: HORIZONS\u2010AMI (The Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) Trial"],"prefix":"10.1161","volume":"6","author":[{"given":"Ioanna","family":"Kosmidou","sequence":"first","affiliation":[{"name":"Clinical Trials Center, Cardiovascular Research Foundation, New York, NY"},{"name":"NewYork\u2010Presbyterian Hospital\/Columbia University Medical Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"McAndrew","sequence":"additional","affiliation":[{"name":"Clinical Trials Center, Cardiovascular Research Foundation, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Redfors","sequence":"additional","affiliation":[{"name":"Clinical Trials Center, Cardiovascular Research Foundation, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Embacher","sequence":"additional","affiliation":[{"name":"Clinical Trials Center, Cardiovascular Research Foundation, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.","family":"Dizon","sequence":"additional","affiliation":[{"name":"Clinical Trials Center, Cardiovascular Research Foundation, New York, NY"},{"name":"NewYork\u2010Presbyterian Hospital\/Columbia University Medical Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana","family":"Mehran","sequence":"additional","affiliation":[{"name":"Clinical Trials Center, Cardiovascular Research Foundation, New York, NY"},{"name":"Icahn School of Medicine at Mount Sinai, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ori","family":"Ben\u2010Yehuda","sequence":"additional","affiliation":[{"name":"Clinical Trials Center, Cardiovascular Research Foundation, New York, NY"},{"name":"NewYork\u2010Presbyterian Hospital\/Columbia University Medical Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary S.","family":"Mintz","sequence":"additional","affiliation":[{"name":"Clinical Trials Center, Cardiovascular Research Foundation, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregg W.","family":"Stone","sequence":"additional","affiliation":[{"name":"Clinical Trials Center, Cardiovascular Research Foundation, New York, NY"},{"name":"NewYork\u2010Presbyterian Hospital\/Columbia University Medical Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3109\/17482941.2014.889312"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp397"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61171-X"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(87)90666-1"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00059-015-4355-7"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(69)90470-6"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/1755-5922.12031"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2010.02.017"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2008.02.008"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0708191"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810116"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013404"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(90)91029-6"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960270207"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.5603\/KP.a2014.0171"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(98)00344-1"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2017.01.019"}],"container-title":["Journal 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