{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T12:13:00Z","timestamp":1770725580952,"version":"3.49.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,8,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Relations of orthostatic change in blood pressure with brain structure and function have not been studied thoroughly, particularly in younger, healthier individuals. Elucidation of factors that contribute to early changes in brain integrity may lead to development of interventions that delay or prevent cognitive impairment.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In a sample of the Framingham Heart Study Third Generation (N=2119; 53% women; mean age\u00b1SD, 47\u00b18\u00a0years), we assessed orthostatic change in mean arterial pressure (\n              <jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content>\n              ), aortic stiffness (carotid\u2010femoral pulse wave velocity), neuropsychological function, and markers of subclinical brain injury on magnetic resonance imaging. Multivariable regression analyses were used to assess relations between orthostatic change in\n              <jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content>\n              and brain structural and neuropsychological outcomes. Greater orthostatic increase in\n              <jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content>\n              on standing was related to better Trails B\u2010A performance among participants aged &lt;49\u00a0years (\u03b2\u00b1\n              <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>\n              , 0.062\u00b10.029;\n              <jats:italic>P<\/jats:italic>\n              =0.031) and among participants with carotid\u2010femoral pulse wave velocity &lt;6.9\u00a0m\/s (\u03b2\u00b1\n              <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>\n              , 0.063\u00b10.026;\n              <jats:italic>P<\/jats:italic>\n              =0.016). This relation was not significant among participants who were older or had stiffer aortas. Conversely, greater orthostatic increase in\n              <jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content>\n              was related to larger total brain volume among older participants (\u03b2\u00b1\n              <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>\n              , 0.065\u00b10.029;\n              <jats:italic>P<\/jats:italic>\n              =0.023) and among participants with carotid\u2010femoral pulse wave velocity \u22656.9\u00a0m\/s (\u03b2\u00b1\n              <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>\n              , 0.078\u00b10.031;\n              <jats:italic>P<\/jats:italic>\n              =0.011).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Blunted orthostatic increase in\n              <jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content>\n              was associated with smaller brain volume among participants who were older\u00a0or had stiffer aortas and with poorer executive function among persons who were younger or who had more\u2010elastic aortas.\u00a0Our findings suggest that the brain is sensitive to orthostatic change in\n              <jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content>\n              , with results dependent on age and aortic stiffness.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.117.006206","type":"journal-article","created":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T18:25:38Z","timestamp":1504290338000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":22,"title":["Inter\u2010Relations of Orthostatic Blood Pressure Change, Aortic Stiffness, and Brain Structure and Function in Young Adults"],"prefix":"10.1161","volume":"6","author":[{"given":"Leroy L.","family":"Cooper","sequence":"first","affiliation":[{"name":"Biology Department, Vassar College, Poughkeepsie, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayandra J.","family":"Himali","sequence":"additional","affiliation":[{"name":"Boston University and NHLBI's Framingham Study, Framingham, MA"},{"name":"Department of Biostatistics, Boston University School of Public Health, Boston, MA"},{"name":"Department of Neurology, Boston University School of Medicine, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alyssa","family":"Torjesen","sequence":"additional","affiliation":[{"name":"Cardiovascular Engineering, Inc., Norwood, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Connie W.","family":"Tsao","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexa","family":"Beiser","sequence":"additional","affiliation":[{"name":"Boston University and NHLBI's Framingham Study, Framingham, MA"},{"name":"Department of Biostatistics, Boston University School of Public Health, Boston, MA"},{"name":"Department of Neurology, Boston University School of Medicine, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi M.","family":"Hamburg","sequence":"additional","affiliation":[{"name":"Evans Department of Medicine, Boston University School of Medicine, Boston, MA"},{"name":"Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"DeCarli","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of California\u2010Davis, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramachandran S.","family":"Vasan","sequence":"additional","affiliation":[{"name":"Boston University and NHLBI's Framingham Study, Framingham, MA"},{"name":"Evans Department of Medicine, Boston University School of Medicine, Boston, MA"},{"name":"Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA"},{"name":"Cardiology and Preventive Medicine Sections, Department of Medicine, Boston University School of Medicine, Boston, MA"},{"name":"Department of Epidemiology, Boston University School of Public Health, Hawthorn, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudha","family":"Seshadri","sequence":"additional","affiliation":[{"name":"Department of Neurology, Boston University School of Medicine, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew P.","family":"Pase","sequence":"additional","affiliation":[{"name":"Boston University and NHLBI's Framingham Study, Framingham, MA"},{"name":"Department of Neurology, Boston University School of Medicine, Boston, MA"},{"name":"Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary F.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Cardiovascular Engineering, Inc., Norwood, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1994.tb07493.x"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.10.2307"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr253"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000257998.33768.87"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.093674"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a43e1c"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2012.07.032"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.06398"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2004.52163.x"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000202816.25706.64"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.08116"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000128420.01881.aa"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.90549.2008"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.551168"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm021"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000020500.77568.3C"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.886655"},{"key":"e_1_3_3_19_2","first-page":"136","volume-title":"Contemporary Intellectual Assessment: Theories, Tests, and Issues","author":"McGrew KS","year":"2005","unstructured":"McGrew KS. The cattell\u2010horn carroll theory of cognitive abilities: past, present and future. In: Flanagan DP, Harrison PL, eds. Contemporary Intellectual Assessment: Theories, Tests, and Issues, 2nd ed. New York, NY: The Guilford Press; 2005:136\u2013181.","edition":"2"},{"key":"e_1_3_3_20_2","volume-title":"Neuropsychological Assessment","author":"Lezak MD","year":"2012","unstructured":"Lezak MD. Neuropsychological Assessment, 5th ed. Oxford; New York: Oxford University Press; 2012.","edition":"5"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.06610"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000150668.58689.f2"},{"key":"e_1_3_3_23_2","first-page":"106","article-title":"MRI non\u2010uniformity correction through interleaved bias estimation and B\u2010spline deformation with a template","volume":"2012","author":"Fletcher E","year":"2012","unstructured":"Fletcher E, Carmichael O, Decarli C. MRI non\u2010uniformity correction through interleaved bias estimation and B\u2010spline deformation with a template. Conf Proc IEEE Eng Med Biol Soc. 2012;2012:106\u2013109.","journal-title":"Conf Proc IEEE Eng Med Biol Soc"},{"key":"e_1_3_3_24_2","first-page":"5319","article-title":"Adaptive image segmentation for robust measurement of longitudinal brain tissue change","volume":"2012","author":"Fletcher E","year":"2012","unstructured":"Fletcher E, Singh B, Harvey D, Carmichael O, Decarli C. Adaptive image segmentation for robust measurement of longitudinal brain tissue change. Conf Proc IEEE Eng Med Biol Soc. 2012;2012:5319\u20135322.","journal-title":"Conf Proc IEEE Eng Med Biol Soc"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70124-8"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1999.tb02576.x"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/59.11.1191"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2007.01.010"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1159\/000160955"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2010.08.056"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01923-X"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(00)00096-8"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)90608-X"},{"key":"e_1_3_3_34_2","first-page":"1824","article-title":"Cerebral hypoperfusion in orthostatic hypotension with globally denervated myocardium","volume":"37","author":"Fukuoka S","year":"1996","unstructured":"Fukuoka S, Hayashida K, Nishiooeda Y, Hirose Y, Miyashita K, Kawano S, Shimotsu Y, Ishida Y, Nishimura T. Cerebral hypoperfusion in orthostatic hypotension with globally denervated myocardium. J Nucl Med. 1996;37:1824\u20131826.","journal-title":"J Nucl Med"},{"key":"e_1_3_3_35_2","first-page":"155","article-title":"Orthostatic hypotension in Alzheimer's disease: result or cause of brain dysfunction?","volume":"11","author":"Siennicki\u2010Lantz A","year":"1999","unstructured":"Siennicki\u2010Lantz A, Lilja B, Elmstahl S. Orthostatic hypotension in Alzheimer's disease: result or cause of brain dysfunction? Aging. 1999;11:155\u2013160.","journal-title":"Aging"},{"key":"e_1_3_3_36_2","first-page":"1","article-title":"Maladaptation of vascular response in frontal area of patients with orthostatic hypotension","volume":"37","author":"Hayashida K","year":"1996","unstructured":"Hayashida K, Nishiooeda Y, Hirose Y, Ishida Y, Nishimura T. Maladaptation of vascular response in frontal area of patients with orthostatic hypotension. J Nucl Med. 1996;37:1\u20134.","journal-title":"J Nucl Med"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01827332"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2015.11.019"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.914507"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.117.006206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:51:51Z","timestamp":1715597511000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.117.006206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,2]]},"references-count":38,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8,2]]}},"alternative-id":["10.1161\/JAHA.117.006206"],"URL":"https:\/\/doi.org\/10.1161\/jaha.117.006206","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,2]]},"assertion":[{"value":"2017-05-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-06-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-08-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e006206"}}