{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T20:46:00Z","timestamp":1774471560629,"version":"3.50.1"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,1,9]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Cardiometabolic health among adult offspring of hypertensive disorders of pregnancy (\n              <jats:styled-content style=\"fixed-case\">HDP<\/jats:styled-content>\n              ) is relatively unknown. We hypothesized that offspring of\n              <jats:styled-content style=\"fixed-case\">HDP<\/jats:styled-content>\n              would have abnormalities in the retinal microvasculature and cardiac structure by midadulthood.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The Cardiovascular Risk in Young Finns Study included randomly selected children from 5 Finnish university cities. The mean age of participants was 40\u00a0years (range 34\u201349\u00a0years) at the time of retinal photography and cardiac assessment. Offspring born \u226537\u00a0weeks of gestation and appropriate for gestational age (n=1006) were included. Offspring of\n              <jats:styled-content style=\"fixed-case\">HDP<\/jats:styled-content>\n              had higher systolic blood pressure (\u03b2=4.68,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), body mass index (\u03b2=1.25,\n              <jats:italic>P<\/jats:italic>\n              =0.009), and waist circumference (\u03b2=0.25,\n              <jats:italic>P<\/jats:italic>\n              =0.042), compared with offspring of normotensive pregnancies. However, no differences in fasting glucose, insulin, lipid profile, carotid intima media thickness, or brachial artery flow\u2010mediated dilatation were shown. Retinal arteriolar diameters were narrower (\u03b2=\u22120.43,\n              <jats:italic>P<\/jats:italic>\n              =0.009) and longer (\u03b2=32.5,\n              <jats:italic>P<\/jats:italic>\n              =0.023) and the arteriolar length\u2010to\u2010diameter ratio was higher (\u03b2=2.32,\n              <jats:italic>P<\/jats:italic>\n              =0.006) among offspring of\n              <jats:styled-content style=\"fixed-case\">HDP<\/jats:styled-content>\n              , after adjustment for age and sex. Left atrial volume indexed to body surface area (\u03b2=1.34,\n              <jats:italic>P<\/jats:italic>\n              =0.040) was increased. Adjustment for the confounding effects of birth weight, body mass index, smoking and socioeconomic status, and the mediating effect of hypertension had little impact on the associations.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Abnormalities of the retinal microvasculature and cardiac structure are seen in offspring of\n              <jats:styled-content style=\"fixed-case\">HDP<\/jats:styled-content>\n              in midadulthood. These findings may need to be considered in future primary prevention strategies of cardiovascular disease among offspring of\n              <jats:styled-content style=\"fixed-case\">HDP<\/jats:styled-content>\n              .\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.117.006284","type":"journal-article","created":{"date-parts":[[2018,1,7]],"date-time":"2018-01-07T01:10:16Z","timestamp":1515287416000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Cardiometabolic Health Among Adult Offspring of Hypertensive Pregnancies: The Cardiovascular Risk in Young Finns Study"],"prefix":"10.1161","volume":"7","author":[{"given":"Robyn J.","family":"Tapp","sequence":"first","affiliation":[{"name":"Melbourne School of Population and Global Health University of Melbourne, Australia"},{"name":"School of Clinical and Applied Sciences, Leeds Beckett University, Leeds, United Kingdom"},{"name":"Department of Optometry and Vision Sciences, The University of Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alun D.","family":"Hughes","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Science, University College London, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mika","family":"K\u00e4h\u00f6nen","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Tampere University Hospital and the University of Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tien Yin","family":"Wong","sequence":"additional","affiliation":[{"name":"Singapore National Eye Center, Singapore &amp; Ophthalmology and Visual Sciences Academic Clinical Program, Duke\u2010NUS Medical School, National University of Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Witt","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terho","family":"Lehtim\u00e4ki","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Hutri\u2010K\u00e4h\u00f6nen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Tampere and Tampere University Hospital, Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pinki","family":"Sahota","sequence":"additional","affiliation":[{"name":"School of Clinical and Applied Sciences, Leeds Beckett University, Leeds, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Juonala","sequence":"additional","affiliation":[{"name":"Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland"},{"name":"Turku University Hospital, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olli T.","family":"Raitakari","sequence":"additional","affiliation":[{"name":"Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland"},{"name":"Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","first-page":"24","article-title":"Pregnancy outcomes in healthy nulliparas who developed hypertension. 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