{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:04:55Z","timestamp":1793329495703,"version":"4.5.0"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Paclitaxel\u2010eluting balloon (\n              <jats:styled-content style=\"fixed-case\">PEB<\/jats:styled-content>\n              ) angioplasty has superior efficacy compared with conventional balloon angioplasty (\n              <jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content>\n              ) for de novo lesions of superficial femoral artery (\n              <jats:styled-content style=\"fixed-case\">SFA<\/jats:styled-content>\n              ). Studies investigating the angiographic and clinical performance of PEB angioplasty versus\n              <jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content>\n              for in\u2010stent restenosis of\n              <jats:styled-content style=\"fixed-case\">SFA<\/jats:styled-content>\n              are limited. We performed a randomized trial to investigate angiographic and clinical performance of\n              <jats:styled-content style=\"fixed-case\">PEB<\/jats:styled-content>\n              versus\n              <jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content>\n              for in\u2010stent restenosis of\n              <jats:styled-content style=\"fixed-case\">SFA<\/jats:styled-content>\n              .\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Patients with symptomatic in\u2010stent restenosis of\n              <jats:styled-content style=\"fixed-case\">SFA<\/jats:styled-content>\n              were randomly assigned to either\n              <jats:styled-content style=\"fixed-case\">PEB<\/jats:styled-content>\n              or\n              <jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content>\n              at 2 centers in Munich, Germany. The primary end point was the percentage diameter stenosis at 6\u2010 to 8\u2010month follow\u2010up angiography. Secondary end points were the rate of binary restenosis at follow\u2010up angiography and target lesion revascularization, target vessel thrombosis, ipsilateral amputation, bypass surgery of the affected limb, and all\u2010cause mortality at 24\u2010month follow\u2010up. Seventy patients were assigned to\n              <jats:styled-content style=\"fixed-case\">PEB<\/jats:styled-content>\n              (n=36) or\n              <jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content>\n              (n=34). Mean lesion length was 139\u00b167\u00a0mm, and roughly one third of lesions were completely occluded at the time of the index procedure. At control angiography, the percentage diameter stenosis (44\u00b133% versus 65\u00b133%,\n              <jats:italic>P<\/jats:italic>\n              =0.01) and binary restenosis were significantly reduced with\n              <jats:styled-content style=\"fixed-case\">PEB<\/jats:styled-content>\n              versus\n              <jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content>\n              (30% versus 59%,\n              <jats:italic>P<\/jats:italic>\n              =0.03). At 24\u2010month follow\u2010up,\n              <jats:styled-content style=\"fixed-case\">PEB<\/jats:styled-content>\n              was associated with a significant reduction of target lesion revascularization in comparison to\n              <jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content>\n              (19% versus 50%,\n              <jats:italic>P<\/jats:italic>\n              =0.007). There was no difference with respect to other outcomes of interest.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In patients with in\u2010stent restenosis of\n              <jats:styled-content style=\"fixed-case\">SFA<\/jats:styled-content>\n              , a percutaneous therapy with\n              <jats:styled-content style=\"fixed-case\">PEB<\/jats:styled-content>\n              compared with\n              <jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content>\n              has superior angiographic performance at 6 to 8\u00a0months and improved clinical efficacy up to 24\u2010month follow\u2010up.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Clinical Trial Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              <jats:styled-content style=\"fixed-case\">URL<\/jats:styled-content>\n              :\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier:\n              <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>\n              01083394.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.117.006321","type":"journal-article","created":{"date-parts":[[2017,7,26]],"date-time":"2017-07-26T00:10:40Z","timestamp":1501027840000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":46,"title":["ISAR\u2010PEBIS (Paclitaxel\u2010Eluting Balloon Versus Conventional Balloon Angioplasty for In\u2010Stent Restenosis of Superficial Femoral Artery): A\u00a0Randomized Trial"],"prefix":"10.1161","volume":"6","author":[{"given":"Ilka","family":"Ott","sequence":"first","affiliation":[{"name":"Deutsches Herzzentrum M\u00fcnchen, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Cassese","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum M\u00fcnchen, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Groha","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum M\u00fcnchen, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Steppich","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum M\u00fcnchen, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Voll","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum M\u00fcnchen, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Hadamitzky","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum M\u00fcnchen, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tareq","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"1. Medizinische Klinik, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Kufner","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum M\u00fcnchen, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Dewitz","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum M\u00fcnchen, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Wittmann","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum M\u00fcnchen, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert Markus","family":"Kasel","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum M\u00fcnchen, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl\u2010Ludwig","family":"Laugwitz","sequence":"additional","affiliation":[{"name":"1. Medizinische Klinik, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heribert","family":"Schunkert","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum M\u00fcnchen, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Kastrati","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum M\u00fcnchen, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Fusaro","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum M\u00fcnchen, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.11.007"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2011.04.003"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.112.969972"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ\u2010D\u201016\u201000735"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.09.036"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.08.045"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2013.11.020"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1583\/13-4420R.1"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.017364"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.04.012"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00614-8"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2014.09.009"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2012.12.118"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/1526602814564385"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.01.007"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2015.12.267"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/1526602815614555"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1583\/13-4308MR.1"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.06.1198"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.117.006321","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:30:10Z","timestamp":1715596210000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.117.006321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":19,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1161\/JAHA.117.006321"],"URL":"https:\/\/doi.org\/10.1161\/jaha.117.006321","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"2017-04-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-06-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-07-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e006321"}}