{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:52:16Z","timestamp":1793040736900,"version":"4.5.0"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,10,11]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Duchenne muscular dystrophy (\n                      <jats:styled-content style=\"fixed-case\">DMD<\/jats:styled-content>\n                      ) is frequently complicated by development of a cardiomyopathy. Despite significant medical advances provided to\n                      <jats:styled-content style=\"fixed-case\">DMD<\/jats:styled-content>\n                      patients over the past 2 decades, there remains a group of\n                      <jats:styled-content style=\"fixed-case\">DMD<\/jats:styled-content>\n                      patients who die prematurely. The current study sought to identify a set of prognostic factors that portend a worse outcome among adult\n                      <jats:styled-content style=\"fixed-case\">DMD<\/jats:styled-content>\n                      patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      A retrospective cohort of 43 consecutive patients was followed in the adult\n                      <jats:styled-content style=\"fixed-case\">UT<\/jats:styled-content>\n                      Southwestern Neuromuscular Cardiomyopathy Clinic. Clinical data were abstracted from the electronic medical record to generate baseline characteristics. The population was stratified by survival to time of analysis and compared with characteristics associated with death. The\n                      <jats:styled-content style=\"fixed-case\">DMD<\/jats:styled-content>\n                      population was in the early 20s, with median follow\u2010up times over 2\u00a0years. All the patients had developed a cardiomyopathy, with the majority of the patients on angiotensin\u2010converting enzyme inhibitors (86%) and steroids (56%), but few other guideline\u2010directed heart failure medications. Comparison between the nonsurviving and surviving cohorts found several poor prognostic factors, including lower body mass index (17.3 [14.8\u201319.3] versus 25.8 [20.8\u201329.1] kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ,\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.01), alanine aminotransferase levels (26 [18\u201342] versus 53 [37\u201381] units\/L,\n                      <jats:italic>P<\/jats:italic>\n                      =0.001), maximum inspiratory pressures (13 [0\u201330] versus 33 [25\u201340] cmH\n                      <jats:sub>2<\/jats:sub>\n                      O,\n                      <jats:italic>P<\/jats:italic>\n                      =0.03), and elevated cardiac biomarkers (N\u2010terminal pro\u2010brain natriuretic peptide: 288 [72\u20131632] versus 35 [21\u2013135] pg\/mL,\n                      <jats:italic>P<\/jats:italic>\n                      =0.03].\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      The findings demonstrate a\n                      <jats:styled-content style=\"fixed-case\">DMD<\/jats:styled-content>\n                      population with a high burden of cardiomyopathy. The nonsurviving cohort was comparatively underweight, and had worse respiratory profiles and elevated cardiac biomarkers. Collectively, these factors highlight a high\u2010risk cardiovascular population with a worse prognosis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.117.006340","type":"journal-article","created":{"date-parts":[[2017,10,17]],"date-time":"2017-10-17T20:10:20Z","timestamp":1508271020000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":75,"title":["Predictors of Death in Adults With Duchenne Muscular Dystrophy\u2013Associated Cardiomyopathy"],"prefix":"10.1161","volume":"6","author":[{"given":"Daniel","family":"Cheeran","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX"},{"name":"Heart Failure, Ventricular Assist Device &amp; Heart Transplant Program, University of Texas Southwestern Medical Center, Dallas, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaida","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohan","family":"Khera","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anish","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX"},{"name":"Heart Failure, Ventricular Assist Device &amp; Heart Transplant Program, University of Texas Southwestern Medical Center, Dallas, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin L.","family":"Grodin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX"},{"name":"Heart Failure, Ventricular Assist Device &amp; Heart Transplant Program, University of Texas Southwestern Medical Center, Dallas, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Morlend","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX"},{"name":"Heart Failure, Ventricular Assist Device &amp; Heart Transplant Program, University of Texas Southwestern Medical Center, Dallas, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faris G.","family":"Araj","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX"},{"name":"Heart Failure, Ventricular Assist Device &amp; Heart Transplant Program, University of Texas Southwestern Medical Center, Dallas, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alpesh A.","family":"Amin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX"},{"name":"Heart Failure, Ventricular Assist Device &amp; Heart Transplant Program, University of Texas Southwestern Medical Center, Dallas, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer T.","family":"Thibodeau","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX"},{"name":"Heart Failure, Ventricular Assist Device &amp; Heart Transplant Program, University of Texas Southwestern Medical Center, Dallas, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark H.","family":"Drazner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX"},{"name":"Heart Failure, Ventricular Assist Device &amp; Heart Transplant Program, University of Texas Southwestern Medical Center, Dallas, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep P. 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