{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T23:41:06Z","timestamp":1769816466992,"version":"3.49.0"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,10,11]]},"abstract":"\n Background<\/jats:title>\n \n Among patients with acute myocardial infarction (\n MI<\/jats:styled-content>\n ) who have multivessel disease, it is unclear if multivessel percutaneous coronary intervention (\n PCI<\/jats:styled-content>\n ) improves clinical and quality\u2010of\u2010life outcomes compared with culprit\u2010only intervention. We sought to compare clinical and quality\u2010of\u2010life outcomes between multivessel and culprit\u2010only\n PCI<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Among 6061 patients with acute\n MI<\/jats:styled-content>\n who have multivessel disease in the\n TRANSLATE\u2010ACS<\/jats:styled-content>\n (Treatment With Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events After Acute Coronary Syndrome) study, we used inverse probability\u2010weighted propensity adjustment to study the associations between multivessel and culprit\u2010only intervention during the index\n PCI<\/jats:styled-content>\n and major adverse cardiovascular events, unplanned all\u2010cause readmission, and angina frequency at 6\u00a0weeks and 1\u00a0year. Multivessel\n PCI<\/jats:styled-content>\n was performed in 1208 (20%) of patients with MI who had multivessel disease. Relative to the culprit\u2010only intervention, patients receiving multivessel\n PCI<\/jats:styled-content>\n were similarly aged and more likely to be seen with\n non\u2013ST\u2010segment elevation MI<\/jats:styled-content>\n or cardiogenic shock. At 6\u00a0weeks, the initial multivessel\n PCI<\/jats:styled-content>\n strategy was associated with lower\n major adverse cardiovascular events<\/jats:styled-content>\n and unplanned readmission risks, whereas angina frequency was not significantly different between multivessel and culprit\u2010only\n PCI<\/jats:styled-content>\n . At 1\u00a0year,\n major adverse cardiovascular event<\/jats:styled-content>\n risk was persistently lower in the multivessel\n PCI<\/jats:styled-content>\n group (adjusted\n hazard ratio,<\/jats:styled-content>\n 0.84; 95% confidence interval, 0.72\u20130.99), whereas long\u2010term readmission risk (adjusted hazard ratio\n ,<\/jats:styled-content>\n 0.94; 95% confidence interval, 0.84\u20131.04) and angina frequency were similar between groups (adjusted\n odds ratio,<\/jats:styled-content>\n 1.01; 95% confidence interval, 0.82\u20131.24). Similar associations were seen when\n patients with ST\u2010segment elevation MI<\/jats:styled-content>\n and\n non\u2013ST\u2010segment elevation MI<\/jats:styled-content>\n were examined separately.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Among patients with acute\n MI<\/jats:styled-content>\n who have multivessel disease, multivessel\n PCI<\/jats:styled-content>\n was associated with lower risk of all\u2010cause readmission at 6\u00a0weeks and lower risk of major adverse cardiovascular events at 6\u00a0weeks and 1\u00a0year. However, similar\u00a0short\u2010 and long\u2010term angina frequencies were noted.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.117.006343","type":"journal-article","created":{"date-parts":[[2017,10,6]],"date-time":"2017-10-06T00:10:26Z","timestamp":1507248626000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":16,"title":["Multivessel Versus Culprit Vessel\u2013Only Percutaneous Coronary Intervention Among Patients With Acute Myocardial Infarction: Insights From the TRANSLATE\u2010ACS Observational Study"],"prefix":"10.1161","volume":"6","author":[{"given":"Homam","family":"Ibrahim","sequence":"first","affiliation":[{"name":"University of Utah Cardiovascular division, Salt Lake City, UT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Praneet K.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Tri\u2010City Cardiology Consultants, Mesa, AZ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Saint Luke's Mid America Heart Institute and University of Missouri\u2010Kansas City School of Medicine, Kansas City, MO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregg C.","family":"Fonarow","sequence":"additional","affiliation":[{"name":"Ahmanson\u2010UCLA Cardiomyopathy Center, Los Angeles, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa A.","family":"Kaltenbach","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Durham, NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark B.","family":"Effron","sequence":"additional","affiliation":[{"name":"Lilly USA, LLC, Indianapolis, IN"},{"name":"John Ochsner Heart and Vascular Institute Ochsner Medical Center, New Orleans, LA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjorie E.","family":"Zettler","sequence":"additional","affiliation":[{"name":"Lilly USA, LLC, Indianapolis, IN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric D.","family":"Peterson","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Durham, NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracy Y.","family":"Wang","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Durham, 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