{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T23:32:15Z","timestamp":1784158335015,"version":"3.55.0"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,9,22]]},"abstract":"\n Background<\/jats:title>\n \n The impact of percutaneous coronary intervention (\n PCI<\/jats:styled-content>\n ) on chronic total occlusion in patients with well\u2010developed collaterals is not clear.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n A total of 640 chronic total occlusion patients with collateral flow grade \u22652 were divided into 2 groups; chronic total occlusion patients either treated with\n PCI<\/jats:styled-content>\n (the\n PCI<\/jats:styled-content>\n group; n=305) or optimal medical therapy (the optimal medical therapy group; n=335). To adjust for potential confounders, a propensity score matching analysis was performed. Major clinical outcomes were compared between the 2 groups up to 5\u00a0years. In the entire population, the\n PCI<\/jats:styled-content>\n group had a lower hazard of myocardial infarction (hazard ratio [\n HR<\/jats:styled-content>\n ], 0.177;\n P<\/jats:italic>\n =0.039; 95% confidence interval [\n CI<\/jats:styled-content>\n ], 0.03\u20130.91) and the composite of total death or myocardial infarction (\n HR<\/jats:styled-content>\n , 0.298;\n P<\/jats:italic>\n =0.017; 95%\n CI<\/jats:styled-content>\n , 0.11\u20130.80); however, it showed higher hazard of target lesion revascularization (\n HR<\/jats:styled-content>\n , 3.942;\n P<\/jats:italic>\n =0.003; 95%\n CI<\/jats:styled-content>\n , 1.58\u20139.81) and target vessel revascularization (\n HR<\/jats:styled-content>\n , 4.218;\n P<\/jats:italic>\n =0.001; 95%\n CI<\/jats:styled-content>\n , 1.85\u20139.60). After propensity score matching, a total of 158 matched pairs were generated. Although the\n PCI<\/jats:styled-content>\n group showed a higher hazard of target lesion revascularization (\n HR<\/jats:styled-content>\n , 2.868;\n P<\/jats:italic>\n =0.027; 95%\n CI<\/jats:styled-content>\n , 1.13\u20137.31) and target vessel revascularization (\n HR<\/jats:styled-content>\n =2.62;\n P<\/jats:italic>\n =0.022; 95%\n CI<\/jats:styled-content>\n , 1.15\u20135.97), it still exhibited a lower incidence of the composite of total death or myocardial infarction (\n HR<\/jats:styled-content>\n , 0.263;\n P<\/jats:italic>\n =0.017; 95%\n CI<\/jats:styled-content>\n , 0.087\u20130.790). The mean ejection fraction was improved from 47.8% to 51.6% (\n P<\/jats:italic>\n <0.001) after\n PCI<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In our study, successful revascularization by\n PCI<\/jats:styled-content>\n for chronic total occlusion lesions with well\u2010developed collaterals was associated with lower incidence of death and myocardial infarction, improved left ventricular function, but increased repeat revascularization rate.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.117.006357","type":"journal-article","created":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T00:10:58Z","timestamp":1505347858000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":29,"title":["Percutaneous Coronary Intervention Versus Optimal Medical Therapy for Chronic Total Coronary Occlusion With Well\u2010Developed Collaterals"],"prefix":"10.1161","volume":"6","author":[{"given":"Se Yeon","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Medicine, Korea University Graduate School, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byoung Geol","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Korea University Graduate School, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung\u2010Woon","family":"Rha","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man Jong","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Korea University Guro Hospital, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang Gi","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Korea University Guro Hospital, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoonjee","family":"Park","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Kyeong","family":"Byun","sequence":"additional","affiliation":[{"name":"Department of Medicine, Korea University Graduate School, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minsuk","family":"Shim","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medicine, Korea University Graduate School, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Mashaly","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Young","family":"Jang","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woohyeun","family":"Kim","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jah Yeon","family":"Choi","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Jin","family":"Park","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Oh","family":"Na","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheol Ung","family":"Choi","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Euy","family":"Lim","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eung Ju","family":"Kim","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Gyu","family":"Park","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Seog","family":"Seo","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Joo","family":"Oh","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01349-3"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2009.10.029"},{"key":"e_1_3_2_4_2","first-page":"1","article-title":"Hybrid approach improves success of chronic total occlusion angioplasty","author":"Wilson WM","year":"2016","unstructured":"Wilson 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