{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:23:33Z","timestamp":1791872613074,"version":"4.3.4"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,8,2]]},"abstract":"\n Background<\/jats:title>\n \n Epicardial adipose tissue (\n EAT<\/jats:styled-content>\n ) is hypothesized to alter atherosclerotic plaque composition, with potential development of high\u2010risk plaque (\n HRP<\/jats:styled-content>\n ).\n EAT<\/jats:styled-content>\n can be measured by volumetric assessment (\n EAT<\/jats:styled-content>\n \u2010v) or linear thickness (\n EAT<\/jats:styled-content>\n \u2010t). We performed a systematic review and random\u2010effects meta\u2010analysis to assess the association of\n EAT<\/jats:styled-content>\n with\n HRP<\/jats:styled-content>\n and whether this association is dependent on the measurement method used.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Electronic databases were systematically searched up to October 2016. Studies reporting\n HRP<\/jats:styled-content>\n by computed tomography or intracoronary imaging and studies measuring\n EAT<\/jats:styled-content>\n \u2010v or\n EAT<\/jats:styled-content>\n \u2010t were included. Odds ratios were extracted from multivariable models reporting the association of\n EAT<\/jats:styled-content>\n with\n HRP<\/jats:styled-content>\n and described as pooled estimates with 95% confidence intervals (\n CIs<\/jats:styled-content>\n ). Analysis was stratified by\n EAT<\/jats:styled-content>\n measurement method. Nine studies (n=3772 patients) were included with 7 measuring\n EAT<\/jats:styled-content>\n \u2010v and 2 measuring\n EAT<\/jats:styled-content>\n \u2010t. Increasing\n EAT<\/jats:styled-content>\n was significantly associated with the presence of\n HRP (odds ratio:<\/jats:styled-content>\n 1.26 [95%\n CI,<\/jats:styled-content>\n 1.11\u20131.43];\n P<\/jats:italic>\n <0.001). Patients with\n HRP<\/jats:styled-content>\n had higher\n EAT<\/jats:styled-content>\n \u2010v than those without (weighted mean difference: 28.3\u00a0mL [95%\n CI,<\/jats:styled-content>\n 18.8\u201337.8\u00a0mL];\n P<\/jats:italic>\n <0.001).\n EAT<\/jats:styled-content>\n \u2010v was associated with\n HRP (odds ratio:<\/jats:styled-content>\n 1.19 [95%\n CI,<\/jats:styled-content>\n 1.06\u20131.33];\n P<\/jats:italic>\n <0.001); however,\n EAT<\/jats:styled-content>\n \u2010t was not (odds ratio: 3.09 [95%\n CI,<\/jats:styled-content>\n 0.56\u201317];\n P<\/jats:italic>\n =0.2). Estimates remained significant when adjusted for small\u2010study effect bias\n (odds ratio:<\/jats:styled-content>\n 1.13 [95%\n CI,<\/jats:styled-content>\n 1.03\u20131.28];\n P<\/jats:italic>\n =0.04).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Increasing\n EAT<\/jats:styled-content>\n is associated with the presence of\n HRP,<\/jats:styled-content>\n and patients with\n HRP<\/jats:styled-content>\n have higher quantified\n EAT<\/jats:styled-content>\n \u2010v. The association of\n EAT<\/jats:styled-content>\n \u2010v with\n HRP<\/jats:styled-content>\n is significant compared with\n EAT<\/jats:styled-content>\n \u2010t; however, a larger scale study is still required, and further evaluation is needed to assess whether\n EAT<\/jats:styled-content>\n may be a potential therapeutic target for novel pharmaceutical agents.\n <\/jats:p>\n <\/jats:sec>\n \n Clinical Trial Registration<\/jats:title>\n \n URL<\/jats:styled-content>\n :\n https:\/\/www.crd.york.ac.uk\/<\/jats:ext-link>\n . Unique identifier:\n CRD<\/jats:styled-content>\n 42017055473.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.117.006379","type":"journal-article","created":{"date-parts":[[2017,8,25]],"date-time":"2017-08-25T00:10:19Z","timestamp":1503619819000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":144,"title":["Association of Epicardial Adipose Tissue and High\u2010Risk Plaque Characteristics: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1161","volume":"6","author":[{"given":"Nitesh","family":"Nerlekar","sequence":"first","affiliation":[{"name":"Monash Cardiovascular Research Centre, Monash University and MonashHeart, Monash Health, Clayton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam J.","family":"Brown","sequence":"additional","affiliation":[{"name":"Monash Cardiovascular Research Centre, Monash University and MonashHeart, Monash Health, Clayton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul G.","family":"Muthalaly","sequence":"additional","affiliation":[{"name":"Monash Cardiovascular Research Centre, Monash University and MonashHeart, Monash Health, Clayton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Talman","sequence":"additional","affiliation":[{"name":"Monash Cardiovascular Research Centre, Monash University and MonashHeart, Monash Health, Clayton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thushan","family":"Hettige","sequence":"additional","affiliation":[{"name":"Monash Cardiovascular Research Centre, Monash University and MonashHeart, Monash Health, Clayton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Cameron","sequence":"additional","affiliation":[{"name":"Monash Cardiovascular Research Centre, Monash University and MonashHeart, Monash Health, Clayton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis T. L.","family":"Wong","sequence":"additional","affiliation":[{"name":"Monash Cardiovascular Research Centre, Monash University and MonashHeart, Monash Health, Clayton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCA.0b013e328351ab2c"},{"key":"e_1_3_4_3_2","first-page":"416","article-title":"Epicardial adipose tissue: far more than a fat depot","volume":"4","author":"Talman AH","year":"2014","unstructured":"Talman AH, Psaltis PJ, Cameron JD, Meredith IT, Seneviratne SK, Wong DT. Epicardial adipose tissue: far more than a fat depot. Cardiovasc Diagn Ther. 2014;4:416\u2013429.","journal-title":"Cardiovasc Diagn Ther"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.03.019"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000582"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-015-0762-3"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.743062"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.300829"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2008.27358"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-668X(02)00426-8"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.05.069"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1002358"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeu188"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2010.12.006"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2011.223024"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-14-135"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-14-25"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-015-0091-1"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.07.007"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2016.05.033"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2012.02.029"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2011.04.021"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcct.2013.02.003"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.07.026"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-15-0477"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-016-0802-5"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2012.11.001"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jes022"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-013-0398-y"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2015.58"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053626"},{"key":"e_1_3_4_34_2","first-page":"4328","article-title":"Epicardial fat volume is correlated with coronary lesion and its severity","volume":"8","author":"Bo X","year":"2015","unstructured":"Bo X, Ma L, Fan J, Jiang Z, Zhou Y, Zhang L, Li W. Epicardial fat volume is correlated with coronary lesion and its severity. Int J Clin Exp Med. 2015;8:4328\u20134334.","journal-title":"Int J Clin Exp Med"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000099542.57313.C5"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.02.022"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2008.11.127"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2015.07.006"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2015.03.018"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.114.002676"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcct.2016.12.007"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2011.01.012"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2011.03.017"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.07.017"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.09.015"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12270"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1186\/1749-8090-9-2"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1089\/met.2013.0107"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.117.006379","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:55:22Z","timestamp":1715597722000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.117.006379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,2]]},"references-count":47,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8,2]]}},"alternative-id":["10.1161\/JAHA.117.006379"],"URL":"https:\/\/doi.org\/10.1161\/jaha.117.006379","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,2]]},"assertion":[{"value":"2017-04-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-07-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-08-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e006379"}}