{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:41:11Z","timestamp":1790728871343,"version":"4.1.0"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,8,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Contrast\u2010induced nephropathy (\n              <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>\n              ) is associated with poor outcomes in patients with acute myocardial infarction. However, the predictors of\n              <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>\n              have yet to be fully elucidated.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The study included 273 consecutive patients with a first\u2010time\n              <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>\n              \u2010segment elevation myocardial infarction who underwent reperfusion within 12\u00a0hours of symptom onset. The exclusion criteria were hemodialysis, mechanical ventilation, or previous coronary artery bypass grafting. All patients underwent arterial blood gas analysis soon after reperfusion.\n              <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>\n              was defined as an increase of 0.5\u00a0mg\/dL in serum creatinine or a 25% increase from baseline between 48 and 72\u00a0hours after contrast medium exposure. Acidosis was defined as an arterial blood\n              <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>\n              &lt;7.35.\n              <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>\n              was observed in 35 patients (12.8%). Multivariable logistic regression analysis with forward stepwise algorithm revealed a significant association between\n              <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>\n              and the following: reperfusion time, the prevalence of hypertension, peak creatine kinase\u2010\n              <jats:styled-content style=\"fixed-case\">MB<\/jats:styled-content>\n              , high\u2010sensitivity C\u2010reactive protein on admission, and the incidence of acidosis (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05). Multivariable logistic regression analysis revealed that the incidence of acidosis was associated with\n              <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>\n              when adjusted for age, male sex, body mass index, amount of contrast medium used, estimated glomerular filtration rate on admission, glucose level on admission, high\u2010sensitivity C\u2010reactive protein on admission, and left ventricular ejection fraction (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05). Moreover, the incidence of acidosis was associated with\n              <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>\n              when adjusted for the Mehran\n              <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>\n              risk score (odds ratio: 2.229,\n              <jats:italic>P<\/jats:italic>\n              =0.049).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The incidence of acidosis soon after reperfusion was associated with\n              <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>\n              in patients with a first\u2010time\n              <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>\n              \u2010segment elevation myocardial infarction.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.117.006380","type":"journal-article","created":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T00:40:30Z","timestamp":1503535230000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":24,"title":["Association Between Acidosis Soon After Reperfusion and Contrast\u2010Induced Nephropathy in Patients With a First\u2010Time ST\u2010Segment Elevation Myocardial Infarction"],"prefix":"10.1161","volume":"6","author":[{"given":"Masaomi","family":"Gohbara","sequence":"first","affiliation":[{"name":"Division of Cardiology, Saiseikai Yokohamashi Nanbu Hospital, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azusa","family":"Hayakawa","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Saiseikai Yokohamashi Nanbu Hospital, Yokohama, 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