{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:50:06Z","timestamp":1792191006081,"version":"4.4.0"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,9,22]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Marfan syndrome (MF) leads to aortic root dilatation and a predisposition to aortic dissection, mitral valve prolapse, and primary and secondary cardiomyopathy. Overall, regular physical exercise is recommended for a healthy lifestyle, but dynamic sports are strongly discouraged in MF patients. Nonetheless, evidence supporting this recommendation is lacking. Therefore, we studied the role of long\u2010term dynamic exercise of moderate intensity on the MF cardiovascular phenotype.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In a transgenic mouse model of MF (\n              <jats:italic>Fbn1<\/jats:italic>\n              <jats:sup>C1039G\/+<\/jats:sup>\n              ), 4\u2010month\u2010old wild\u2010type and MF mice were subjected to training on a treadmill for 5\u00a0months; sedentary littermates served as controls for each group. Aortic and cardiac remodeling was assessed by echocardiography and histology. The 4\u2010month\u2010old MF mice showed aortic root dilatation, elastic lamina rupture, and tunica media fibrosis, as well as cardiac hypertrophy, left ventricular fibrosis, and intramyocardial vessel remodeling. Over the 5\u2010month experimental period, aortic root dilation rate was significantly greater in the sedentary MF group, compared with the wild\u2010type group (\u2206mm, 0.27\u00b10.07 versus 0.13\u00b10.02, respectively). Exercise significantly blunted the aortic root dilation rate in MF mice compared with sedentary MF littermates (\u2206mm, 0.10\u00b10.04 versus 0.27\u00b10.07, respectively). However, these 2 groups were indistinguishable by aortic root stiffness, tunica media fibrosis, and elastic lamina ruptures. In MF mice, exercise also produced cardiac hypertrophy regression without changes in left ventricular fibrosis.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Our results in a transgenic mouse model of MF indicate that moderate dynamic exercise mitigates the progression of the MF cardiovascular phenotype.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.117.006438","type":"journal-article","created":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T00:25:31Z","timestamp":1506385531000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":62,"title":["Cardiovascular Benefits of Moderate Exercise Training in Marfan Syndrome: Insights From an Animal Model"],"prefix":"10.1161","volume":"6","author":[{"given":"Aleksandra","family":"Mas\u2010Stachurska","sequence":"first","affiliation":[{"name":"Institut 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