{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:29:14Z","timestamp":1790620154544,"version":"4.1.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,1,23]]},"abstract":"\n Background<\/jats:title>\n \n Soluble lectin\u2010like oxidized low\u2010density lipoprotein receptor\u20101 (\n sLOX<\/jats:styled-content>\n \u20101) has been shown to be increased in patients with acute ischemic stroke. Here, we evaluated plasma\n sLOX<\/jats:styled-content>\n \u20101 levels and vascular carotid plaque\n LOX<\/jats:styled-content>\n \u20101 (ie,\n \n OLR<\/jats:styled-content>\n 1\n <\/jats:italic>\n ) gene expression in patients with ischemic stroke and transient ischemic attack (\n TIA<\/jats:styled-content>\n ) with particular focus on their relation to time since symptom onset.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Plasma\n sLOX<\/jats:styled-content>\n \u20101 (n=232) and carotid plaque\n \n OLR<\/jats:styled-content>\n 1\n <\/jats:italic>\n gene expression (n=146) were evaluated in patients who were referred to evaluation for carotid endarterectomy, as well as in healthy control plasma (n=81). Patients were categorized according to presence of acute ischemic stroke or transient ischemic attack (n=35) \u22647\u00a0days, >7\u00a0days \u22643\u00a0months (n=90), >3\u00a0months (n=40), or no reported symptoms before study inclusion (n=67). Our major findings were the following: (1) Patients with carotid atherosclerosis had increased plasma\n sLOX<\/jats:styled-content>\n \u20101 levels as compared with controls. (2) Plaque\n \n OLR<\/jats:styled-content>\n 1\n <\/jats:italic>\n mRNA<\/jats:styled-content>\n levels were increased in carotid plaques (n=146) compared with nonatherosclerotic vessels (ie, common iliac arteries of organ donors, n=10). (3) There were no differences in\n sLOX<\/jats:styled-content>\n plasma levels or\n \n OLR<\/jats:styled-content>\n 1\n <\/jats:italic>\n gene expression when analyzed according to the time since relevant cerebral ischemic symptoms. (4) Also patients with severe carotid atherosclerosis without any previous ischemic events had raised\n sLOX<\/jats:styled-content>\n \u20101 levels. (5) Immunostaining showed colocalization between\n LOX<\/jats:styled-content>\n \u20101 and macrophages within the carotid plaques. (6) Also patients with acute stroke (within 7\u00a0days) caused by atrial fibrillation (n=22) had comparable raised\n sLOX<\/jats:styled-content>\n \u20101 levels.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n sLOX<\/jats:styled-content>\n \u20101 levels are elevated in patients with ischemic stroke and transient ischemic attack independent of cause and time since the ischemic event.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.117.006479","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T20:10:36Z","timestamp":1515787836000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":48,"title":["Increased Levels of Lectin\u2010Like Oxidized Low\u2010Density Lipoprotein Receptor\u20101 in Ischemic Stroke and Transient Ischemic Attack"],"prefix":"10.1161","volume":"7","author":[{"given":"Tonje","family":"Skarpengland","sequence":"first","affiliation":[{"name":"Oslo University Hospital Rikshospitalet","place":["Oslo, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Skjelland","sequence":"additional","affiliation":[{"name":"Oslo University Hospital Rikshospitalet","place":["Oslo, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang Yi","family":"Kong","sequence":"additional","affiliation":[{"name":"Oslo University Hospital Rikshospitalet","place":["Oslo, Norway"]},{"name":"University of Oslo","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Skagen","sequence":"additional","affiliation":[{"name":"Oslo University Hospital Rikshospitalet","place":["Oslo, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sverre","family":"Holm","sequence":"additional","affiliation":[{"name":"Oslo University Hospital Rikshospitalet","place":["Oslo, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari","family":"Otterdal","sequence":"additional","affiliation":[{"name":"Oslo University Hospital Rikshospitalet","place":["Oslo, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christen P.","family":"Dahl","sequence":"additional","affiliation":[{"name":"Oslo University Hospital Rikshospitalet","place":["Oslo, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Krohg\u2010S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Oslo University Hospital Rikshospitalet","place":["Oslo, Norway"]},{"name":"University of Oslo","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen L.","family":"Sagen","sequence":"additional","affiliation":[{"name":"Oslo University Hospital Rikshospitalet","place":["Oslo, Norway"]},{"name":"University of Oslo","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vigdis","family":"Bjerkeli","sequence":"additional","affiliation":[{"name":"Oslo University Hospital Rikshospitalet","place":["Oslo, Norway"]},{"name":"University of Oslo","place":["Norway"]},{"name":"University of Oslo","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Hege","family":"Aamodt","sequence":"additional","affiliation":[{"name":"Oslo University Hospital Rikshospitalet","place":["Oslo, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azhar","family":"Abbas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida","family":"Gregersen","sequence":"additional","affiliation":[{"name":"Oslo University Hospital Rikshospitalet","place":["Oslo, Norway"]},{"name":"University of Oslo","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e5l","family":"Aukrust","sequence":"additional","affiliation":[{"name":"Oslo University Hospital Rikshospitalet","place":["Oslo, Norway"]},{"name":"Oslo University Hospital Rikshospitalet","place":["Oslo, Norway"]},{"name":"University of Oslo","place":["Norway"]},{"name":"University of Oslo","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bente","family":"Halvorsen","sequence":"additional","affiliation":[{"name":"Oslo University Hospital Rikshospitalet","place":["Oslo, Norway"]},{"name":"University of Oslo","place":["Norway"]},{"name":"University of Oslo","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuva B.","family":"Dahl","sequence":"additional","affiliation":[{"name":"Oslo University Hospital Rikshospitalet","place":["Oslo, Norway"]},{"name":"Oslo University Hospital Rikshospitalet","place":["Oslo, 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