{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T11:32:33Z","timestamp":1783078353787,"version":"3.54.6"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,10,11]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              There is a paucity of data regarding late\u2010onset pulmonary hypertension (\n              <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>\n              ) in patients with transposition of the great arteries and atrial switch surgery.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              A retrospective cohort study was conducted on 140 adults with transposition of the great arteries and atrial switch surgery, age 37.3\u00b17.8, 37.1% female, in order to assess the prevalence and characteristics of late\u2010onset\n              <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>\n              and explore associated factors. Patients were followed for a median of 32.3\u00a0years after atrial switch surgery and 10.0\u00a0years after their first referral visit.\n              <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>\n              was detected in 18 of 33 (54.5%) patients who had invasive hemodynamic studies. Average age at diagnosis of\n              <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>\n              was 33.9\u00b18.1\u00a0years.\n              <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>\n              was postcapillary in all, with a mean pulmonary artery pressure of 36\u00b112\u00a0mm\u00a0Hg and mean pulmonary capillary wedge pressure of 28\u00b18\u00a0mm\u00a0Hg.\n              <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>\n              was diagnosed in 13 of 17 (76.5%) patients who had cardiac catheterization for heart failure or decreased exercise tolerance. In multivariable analyses, systemic hypertension (odds ratio 9.4, 95% confidence interval 2.2\u201039.4,\n              <jats:italic>P<\/jats:italic>\n              =0.002) and heart failure or New York Heart Association class\n              <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\n              or\n              <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\n              symptoms (odds ratio 49.8, 95% confidence interval 8.6\u2010289.0,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) were independently associated with\n              <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>\n              . Patients with\n              <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>\n              were more likely to develop cardiovascular comorbidities including atrial (\n              <jats:italic>P<\/jats:italic>\n              =0.001) and ventricular (\n              <jats:italic>P<\/jats:italic>\n              =0.008) arrhythmias, require hospitalizations for heart failure (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), and undergo tricuspid valve surgery (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Mortality was significantly higher in patients with\n              <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>\n              (hazard ratio 9.4, 95% confidence interval 2.1\u201043.0],\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Late\u2010onset postcapillary\n              <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>\n              is highly prevalent in adults with transposition of the great arteries and atrial switch surgery and is associated with an adverse prognosis.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.117.006481","type":"journal-article","created":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T00:10:27Z","timestamp":1507853427000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Late Onset Postcapillary Pulmonary Hypertension in Patients With Transposition of the Great Arteries and Mustard or Senning Baffles"],"prefix":"10.1161","volume":"6","author":[{"given":"Marie\u2010A.","family":"Chaix","sequence":"first","affiliation":[{"name":"Adult Congenital Heart Centre, Montreal Heart Institute, Universit\u00e9 de Montr\u00e9al, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Dore","sequence":"additional","affiliation":[{"name":"Adult Congenital Heart Centre, Montreal Heart Institute, Universit\u00e9 de Montr\u00e9al, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise\u2010Andr\u00e9e","family":"Mercier","sequence":"additional","affiliation":[{"name":"Adult Congenital Heart Centre, Montreal Heart Institute, Universit\u00e9 de Montr\u00e9al, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois\u2010Pierre","family":"Mongeon","sequence":"additional","affiliation":[{"name":"Adult Congenital Heart Centre, Montreal Heart Institute, Universit\u00e9 de Montr\u00e9al, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Marcotte","sequence":"additional","affiliation":[{"name":"Adult Congenital Heart Centre, Montreal Heart Institute, Universit\u00e9 de Montr\u00e9al, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9da","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Adult Congenital Heart Centre, Montreal Heart Institute, Universit\u00e9 de Montr\u00e9al, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita W.","family":"Asgar","sequence":"additional","affiliation":[{"name":"Adult Congenital Heart Centre, Montreal Heart Institute, Universit\u00e9 de Montr\u00e9al, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azadeh","family":"Shohoudi","sequence":"additional","affiliation":[{"name":"Montreal Health Innovation Coordinating Centre (MHICC), Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Labombarda","sequence":"additional","affiliation":[{"name":"Adult Congenital Heart Centre, Montreal Heart Institute, Universit\u00e9 de Montr\u00e9al, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blandine","family":"Mond\u00e9sert","sequence":"additional","affiliation":[{"name":"Adult Congenital Heart Centre, Montreal Heart Institute, Universit\u00e9 de Montr\u00e9al, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Poirier","sequence":"additional","affiliation":[{"name":"Adult Congenital Heart Centre, Montreal Heart Institute, Universit\u00e9 de Montr\u00e9al, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Khairy","sequence":"additional","affiliation":[{"name":"Adult Congenital Heart Centre, Montreal Heart Institute, Universit\u00e9 de Montr\u00e9al, Quebec, Canada"},{"name":"Montreal Health Innovation Coordinating Centre (MHICC), Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.08.025"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.40.2.237"},{"key":"e_1_3_3_4_2","first-page":"966","article-title":"Surgical correction of transposition of the great vessels","volume":"45","author":"Senning A","year":"1959","unstructured":"Senning A. 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