{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:38:47Z","timestamp":1790699927376,"version":"4.1.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,7]]},"abstract":"\n Background<\/jats:title>\n \n The\n ABC<\/jats:styled-content>\n \u2010stroke score (age, biomarkers [N\u2010terminal fragment B\u2010type natriuretic peptide, high\u2010sensitivity troponin], and clinical history [prior stroke\/transient ischemic attack]) was proposed to predict stroke in atrial fibrillation (\n AF<\/jats:styled-content>\n ). This score was derived\/validated in 2 clinical trial cohorts in which patients with AF were highly selected and carefully followed\u2010up. However, the median follow\u2010up was 1.9\u00a0years in the trial cohort; therefore, its long\u2010term predictive performance remains uncertain. This study aimed to compare the long\u2010term predictive performances of the\n ABC<\/jats:styled-content>\n \u2010stroke and\n CHA<\/jats:styled-content>\n 2<\/jats:sub>\n DS<\/jats:styled-content>\n 2<\/jats:sub>\n \u2010\n VAS<\/jats:styled-content>\n c (cardiac failure or dysfunction, hypertension, age \u226575 [doubled], diabetes mellitus, stroke [doubled]\u2014vascular disease, age 65 to 74\u00a0years and sex category [female]) scores in a cohort of anticoagulated patients with AF.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We recruited 1125 consecutive patients with AF who were stable on vitamin K antagonists and followed\u2010up for a median of 6.5\u00a0years.\n ABC<\/jats:styled-content>\n \u2010stroke and\n CHA<\/jats:styled-content>\n 2<\/jats:sub>\n DS<\/jats:styled-content>\n 2<\/jats:sub>\n \u2010\n VAS<\/jats:styled-content>\n c (cardiac failure or dysfunction, hypertension, age \u226575 [doubled], diabetes mellitus, stroke [doubled]\u2014vascular disease, age 65 to 74\u00a0years and sex category [female]) scores were calculated and compared. Median\n CHA<\/jats:styled-content>\n 2<\/jats:sub>\n DS<\/jats:styled-content>\n 2<\/jats:sub>\n \u2010\n VAS<\/jats:styled-content>\n c and\n ABC<\/jats:styled-content>\n \u2010stroke scores were 4 (interquartile range 3\u20135) and 9.1 (interquartile range 7.3\u201311.3), respectively. There were 114 ischemic strokes (1.55% per year) at 6.5\u00a0years. The C\u2010index of\n ABC<\/jats:styled-content>\n \u2010stroke at 3.5\u00a0years was significantly higher than\n CHA<\/jats:styled-content>\n 2<\/jats:sub>\n DS<\/jats:styled-content>\n 2<\/jats:sub>\n \u2010\n VAS<\/jats:styled-content>\n c (0.663 versus 0.600,\n P<\/jats:italic>\n =0.046), but both C\u2010indexes were nonsignificantly different at 6.5\u00a0years. Integrated discrimination improvement showed a small improvement (<2%) in sensitivity at 3.5 and 6.5\u00a0years with\n ABC<\/jats:styled-content>\n \u2010stroke. For\n ABC<\/jats:styled-content>\n \u2010stroke, net reclassification improvement was nonsignificantly different at 3.5\u00a0years, and showed a negative reclassification at 6.5\u00a0years compared with\n CHA<\/jats:styled-content>\n 2<\/jats:sub>\n DS<\/jats:styled-content>\n 2<\/jats:sub>\n \u2010\n VAS<\/jats:styled-content>\n c. Decision curve analyses did not show a marked improvement in clinical usefulness of the\n ABC<\/jats:styled-content>\n \u2010stroke score over the\n CHA<\/jats:styled-content>\n 2<\/jats:sub>\n DS<\/jats:styled-content>\n 2<\/jats:sub>\n \u2010\n VAS<\/jats:styled-content>\n c score.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In anticoagulated patients with AF followed\u2010up over a long\u2010term period, the novel\n ABC<\/jats:styled-content>\n \u2010stroke score does not offer significantly better predictive performance compared with the\n CHA<\/jats:styled-content>\n 2<\/jats:sub>\n DS<\/jats:styled-content>\n 2<\/jats:sub>\n \u2010\n VAS<\/jats:styled-content>\n c score.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.117.006490","type":"journal-article","created":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T00:10:36Z","timestamp":1500595836000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":40,"title":["Long\u2010Term Stroke Risk Prediction in Patients With Atrial Fibrillation: Comparison of the ABC\u2010Stroke and CHA\n 2<\/sub>\n DS\n 2<\/sub>\n \u2010VASc Scores"],"prefix":"10.1161","volume":"6","author":[{"given":"Jos\u00e9 Miguel","family":"Rivera\u2010Caravaca","sequence":"first","affiliation":[{"name":"Department of Hematology and Clinical Oncology, Hospital General Universitario Morales Meseguer, Instituto Murciano de Investigaci\u00f3n Biosanitaria (IMIB\u2010Arrixaca), University of Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Rold\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Hematology and Clinical Oncology, Hospital General Universitario Morales Meseguer, Instituto Murciano de Investigaci\u00f3n Biosanitaria (IMIB\u2010Arrixaca), University of Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Asunci\u00f3n","family":"Esteve\u2010Pastor","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, Instituto Murciano de Investigaci\u00f3n Biosanitaria (IMIB\u2010Arrixaca), CIBERCV, Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Vald\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, Instituto Murciano de Investigaci\u00f3n Biosanitaria (IMIB\u2010Arrixaca), CIBERCV, Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Vicente","sequence":"additional","affiliation":[{"name":"Department of Hematology and Clinical Oncology, Hospital General Universitario Morales Meseguer, Instituto Murciano de Investigaci\u00f3n Biosanitaria (IMIB\u2010Arrixaca), University of Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory Y. H.","family":"Lip","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences, University of Birmingham, United Kingdom"},{"name":"Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Mar\u00edn","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, Instituto Murciano de Investigaci\u00f3n Biosanitaria (IMIB\u2010Arrixaca), CIBERCV, Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-1584"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw210"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0000000000000041"},{"key":"e_1_3_4_5_2","unstructured":"National\u2010Institute\u2010for\u2010Health\u2010and\u2010Care\u2010Excellence . 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