{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:54:57Z","timestamp":1787018097585,"version":"build-2736575974"},"reference-count":53,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,9,22]]},"abstract":"\n Background<\/jats:title>\n Arterial stiffness is a well\u2010known predictor of future cardiovascular events. Search for the underlying mechanism of arterial stiffening is still under way. We investigated the relationship between arterial stiffness and cytomegalovirus infection in terms of T\u2010cell senescence.<\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Arterial stiffness was evaluated using pulse wave velocity measurements in 415 Koreans (age 59\u00b112\u00a0years). We also investigated the frequency of\n CD<\/jats:styled-content>\n 57\n +<\/jats:sup>\n or\n CD<\/jats:styled-content>\n 28\n null<\/jats:sup>\n senescent T cells in peripheral blood lymphocytes and analyzed which immune parameters were correlated with pulse wave velocity. Furthermore, cytomegalovirus\u2010specific T cells were stimulated with overlapping peptides covering pp65 protein, and T\u2010cell function was evaluated by intracellular cytokine staining of interferon\u2010\u03b3, tumor necrosis factor\u2010\u03b1, and\n CD<\/jats:styled-content>\n 107a. In a multivariate analysis, it was found that the frequency of\n CD<\/jats:styled-content>\n 57\n +<\/jats:sup>\n cells in the\n CD<\/jats:styled-content>\n 8\n +<\/jats:sup>\n T\u2010cell subset was independently correlated with pulse wave velocity after adjusting for traditional cardiovascular risk factors such as age, sex, diabetes mellitus history, smoking history, body mass index, blood pressure, serum creatinine, high\u2010density lipoprotein cholesterol, and high\u2010sensitivity C\u2010reactive protein. Cytomegalovirus pp65\u2010specific T cells were more frequently observed in the\n CD<\/jats:styled-content>\n 8\n +<\/jats:sup>\n CD<\/jats:styled-content>\n 57\n +<\/jats:sup>\n population than in the\n CD<\/jats:styled-content>\n 8\n +<\/jats:sup>\n CD<\/jats:styled-content>\n 57\n \u2212<\/jats:sup>\n population, and multivariate analysis revealed that the frequency of cytomegalovirus pp65\u2010specific interferon\u2010\u03b3\n +<\/jats:sup>\n , tumor necrosis factor\u2010\u03b1\n +<\/jats:sup>\n , or\n CD<\/jats:styled-content>\n 107a\n +<\/jats:sup>\n cells in the\n CD<\/jats:styled-content>\n 8\n +<\/jats:sup>\n T\u2010cell subset was independently correlated with pulse wave velocity as well.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n We demonstrate that arterial stiffness is associated with senescent\n CD<\/jats:styled-content>\n 57\n +<\/jats:sup>\n T cells and\n CMV<\/jats:styled-content>\n pp65\u2010specific T cells in the\n CD<\/jats:styled-content>\n 8\n +<\/jats:sup>\n T\u2010cell subset. The precise role of cytomegalovirus\u2010specific, senescent T cells in vascular aging needs to be further investigated.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.117.006535","type":"journal-article","created":{"date-parts":[[2017,8,28]],"date-time":"2017-08-28T21:00:38Z","timestamp":1503954038000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":47,"title":["Arterial Stiffness Is Associated With Cytomegalovirus\u2010Specific Senescent CD8\n +<\/sup>\n T Cells"],"prefix":"10.1161","volume":"6","author":[{"given":"Hee Tae","family":"Yu","sequence":"first","affiliation":[{"name":"Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, KAIST, Daejeon, Korea"},{"name":"Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong\u2010Chan","family":"Youn","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, KAIST, Daejeon, Korea"},{"name":"Division of Cardiology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, KAIST, Daejeon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeon\u2010Jae","family":"Seong","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, KAIST, Daejeon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su\u2010Hyung","family":"Park","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Immunology and Vaccinology, Graduate School of Medical Science and Engineering, KAIST, Daejeon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeon Chang","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Cardiovascular and Metabolic Diseases Etiology Research Center, Yonsei University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won\u2010Woo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology and Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungha","family":"Park","sequence":"additional","affiliation":[{"name":"Division 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