{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T01:17:47Z","timestamp":1793582267584,"version":"4.5.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,11]]},"abstract":"\n Background<\/jats:title>\n \n Left atrium (\n LA<\/jats:styled-content>\n ) enlargement is common in patients with aortic stenosis (\n AS<\/jats:styled-content>\n ), yet its prognostic implications are unclear. This study investigates the value of left atrial volume (\n LAV<\/jats:styled-content>\n ) and\n LAV<\/jats:styled-content>\n normalized to body size for predicting mortality in\n AS<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We included 1351 patients with\n AS<\/jats:styled-content>\n in sinus rhythm at diagnosis and analyzed the occurrence of all\u2010cause death during follow\u2010up with medical and surgical management. Five parameters of\n LA<\/jats:styled-content>\n enlargement were tested: nonindexed\n LAV<\/jats:styled-content>\n and normalized\n LAV<\/jats:styled-content>\n by ratiometric (\n LAV<\/jats:styled-content>\n \/body surface area [\n BSA<\/jats:styled-content>\n ] and\n LAV<\/jats:styled-content>\n \/height) and allometric (\n LAV<\/jats:styled-content>\n \/\n BSA<\/jats:styled-content>\n 1.7<\/jats:sup>\n and\n LAV<\/jats:styled-content>\n \/height\n 2.0<\/jats:sup>\n ) scaling. For each parameter, patients in the highest quartile were at high risk of death, whereas outcome was better and similar for the other quartiles. Five\u2010year survival was lower for patients with\n LAV<\/jats:styled-content>\n >95\u00a0mL and\n LAV<\/jats:styled-content>\n \/\n BSA<\/jats:styled-content>\n >50\u00a0mL\/m\n 2<\/jats:sup>\n compared with those with no or mild\n LA<\/jats:styled-content>\n enlargement (both\n P<\/jats:italic>\n <0.001). After adjustment for established outcome predictors, including surgery, high risk of death was observed with\n LAV<\/jats:styled-content>\n >95\u00a0mL (adjusted hazard ratio, 1.40 [95% confidence interval, 1.06\u20131.88]) and\n LAV<\/jats:styled-content>\n \/\n BSA<\/jats:styled-content>\n >50\u00a0mL\/m\n 2<\/jats:sup>\n (adjusted hazard ratio, 1.42 [95% confidence interval, 1.08\u20131.91]).\n LAV<\/jats:styled-content>\n \/\n BSA<\/jats:styled-content>\n and LAV showed good and similar predictive performance, whereas other scaling methods did not show better outcome prediction. In patients with severe\n AS<\/jats:styled-content>\n at baseline, preserved (\u226550%) ejection fraction, and no or minimal symptoms,\n LA<\/jats:styled-content>\n enlargement was significantly associated with mortality (adjusted hazard ratio, 1.87 [95% confidence interval, 1.02\u20133.44] for\n LAV<\/jats:styled-content>\n >95\u00a0mL, and adjusted hazard ratio, 1.90 [95% confidence interval, 1.03\u20133.56] for\n LAV<\/jats:styled-content>\n \/\n BSA<\/jats:styled-content>\n >50\u00a0mL\/m\n 2<\/jats:sup>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n LA<\/jats:styled-content>\n enlargement is an important predictor of mortality in\n AS<\/jats:styled-content>\n , incrementally to known predictors of outcome.\n LAV<\/jats:styled-content>\n and\n LAV<\/jats:styled-content>\n \/\n BSA<\/jats:styled-content>\n have comparable predictive performance and should be assessed in clinical practice for risk stratification.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.117.006615","type":"journal-article","created":{"date-parts":[[2017,10,31]],"date-time":"2017-10-31T20:10:42Z","timestamp":1509480642000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":68,"title":["Left Atrial Volume and Mortality in Patients With Aortic Stenosis"],"prefix":"10.1161","volume":"6","author":[{"given":"Dan","family":"Rusinaru","sequence":"first","affiliation":[{"name":"P\u00f4le Coeur\u2010Thorax\u2010Vaisseaux, Department of Cardiology, University Hospital Amiens, Amiens, France"},{"name":"INSERM U\u20101088, Jules Verne University of Picardie, Amiens, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohann","family":"Bohbot","sequence":"additional","affiliation":[{"name":"P\u00f4le Coeur\u2010Thorax\u2010Vaisseaux, Department of Cardiology, University Hospital Amiens, Amiens, 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