{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:27:16Z","timestamp":1790054836527,"version":"4.0.1"},"reference-count":61,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,9,22]]},"abstract":"\n Background<\/jats:title>\n \n ATP and derivatives are recognized to be essential agents of paracrine signaling. It was reported that\n ATP<\/jats:styled-content>\n is an important regulator of the pressure\u2010natriuresis mechanism. Information on the sources of\n ATP<\/jats:styled-content>\n , the mechanisms of its release, and its relationship to blood pressure has been limited by the inability to precisely measure dynamic changes in intrarenal\n ATP<\/jats:styled-content>\n levels in\u00a0vivo.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Newly developed amperometric biosensors were used to assess alterations in cortical\n ATP<\/jats:styled-content>\n concentrations in response to changes in renal perfusion pressure (\n RPP<\/jats:styled-content>\n ) in anesthetized Sprague\u2013Dawley rats.\n RPP<\/jats:styled-content>\n was monitored via the carotid artery; ligations around the celiac\/superior mesenteric arteries and the distal aorta were used for manipulation of\n RPP<\/jats:styled-content>\n . Biosensors were acutely implanted in the renal cortex for assessment of\n ATP<\/jats:styled-content>\n . Rise of\n RPP<\/jats:styled-content>\n activated diuresis\/natriuresis processes, which were associated with elevated\n ATP<\/jats:styled-content>\n . The increases in cortical\n ATP<\/jats:styled-content>\n concentrations were in the physiological range (1\u20133\u00a0\u03bcmol\/L) and would be capable of activating most of the purinergic receptors. There was a linear correlation with every 1\u2010mm\u00a0Hg rise in\n RPP<\/jats:styled-content>\n resulting in a 70\u2010nmol\/L increase in\n ATP<\/jats:styled-content>\n . Furthermore, this elevation of\n RPP<\/jats:styled-content>\n was accompanied by a 2.5\u2010fold increase in urinary H\n 2<\/jats:sub>\n O\n 2<\/jats:sub>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Changes in\n RPP<\/jats:styled-content>\n directly correlate with renal sodium excretion and the elevation of cortical\n ATP<\/jats:styled-content>\n . Given the known effects of\n ATP<\/jats:styled-content>\n on regulation of glomerular filtration and tubular transport, the data support a role for\n ATP<\/jats:styled-content>\n release in the rapid natriuretic responses to acute increases in\n RPP<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.117.006658","type":"journal-article","created":{"date-parts":[[2017,9,13]],"date-time":"2017-09-13T00:10:49Z","timestamp":1505261449000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":25,"title":["Acute In Vivo Analysis of ATP Release in Rat Kidneys in Response to Changes of Renal Perfusion Pressure"],"prefix":"10.1161","volume":"6","author":[{"given":"Oleg","family":"Palygin","sequence":"first","affiliation":[{"name":"Department of Physiology, Medical College of Wisconsin, Milwaukee, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise C.","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Physiology, Medical College of Wisconsin, Milwaukee, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Allen W.","family":"Cowley","sequence":"additional","affiliation":[{"name":"Department of Physiology, Medical College of Wisconsin, Milwaukee, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Staruschenko","sequence":"additional","affiliation":[{"name":"Department of Physiology, Medical College of Wisconsin, Milwaukee, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.34.030172.000305"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1992.72.1.231"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2063193"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.018526"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V103492"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.309726"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11302-013-9400-5"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12372"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014070721"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.155952"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI18499"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1996.271.5.F1077"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11302-009-9148-0"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00071.2002"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12507"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M807129200"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2009.02002.x"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006070700"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0736323100"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.466102"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2013.00194"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00242.2005"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.86.6.656"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.37.2.753"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00129.2013"},{"key":"e_1_3_4_27_2","first-page":"e53059","article-title":"Use of enzymatic biosensors to quantify endogenous ATP or H2O2 in the kidney","volume":"104","author":"Palygin O","year":"2015","unstructured":"Palygin O, Levchenko V, Evans LC, Blass G, Cowley AW Jr, Staruschenko A. 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