{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:07:21Z","timestamp":1790482041724,"version":"4.1.0"},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,1,23]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Transplantation of adventitial pericytes (\n              <jats:styled-content style=\"fixed-case\" toggle=\"no\">APC<\/jats:styled-content>\n              s) promotes cardiac repair in murine models of myocardial infarction. The aim of present study was to confirm the benefit of\n              <jats:styled-content style=\"fixed-case\" toggle=\"no\">APC<\/jats:styled-content>\n              therapy in a large animal model.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We performed a blind, randomized, placebo\u2010controlled\n              <jats:styled-content style=\"fixed-case\" toggle=\"no\">APC<\/jats:styled-content>\n              therapy trial in a swine model of reperfused myocardial infarction. A first study used human\n              <jats:styled-content style=\"fixed-case\" toggle=\"no\">APC<\/jats:styled-content>\n              s (\n              <jats:styled-content style=\"fixed-case\" toggle=\"no\">hAPC<\/jats:styled-content>\n              s) from patients undergoing coronary artery bypass graft surgery. A second study used allogeneic swine\n              <jats:styled-content style=\"fixed-case\" toggle=\"no\">APC<\/jats:styled-content>\n              s (\n              <jats:styled-content style=\"fixed-case\" toggle=\"no\">sAPC<\/jats:styled-content>\n              s). Primary end points were (1) ejection fraction as assessed by cardiac magnetic resonance imaging and (2) myocardial vascularization and fibrosis as determined by immunohistochemistry. Transplantation of\n              <jats:styled-content style=\"fixed-case\" toggle=\"no\">hAPC<\/jats:styled-content>\n              s reduced fibrosis but failed to improve the other efficacy end points. Incompatibility of the xenogeneic model was suggested by the occurrence of a cytotoxic response following in\u00a0vitro challenge of\n              <jats:styled-content style=\"fixed-case\" toggle=\"no\">hAPC<\/jats:styled-content>\n              s with swine spleen lymphocytes and the failure to retrieve\n              <jats:styled-content style=\"fixed-case\" toggle=\"no\">hAPC<\/jats:styled-content>\n              s in transplanted hearts. We next considered\n              <jats:styled-content style=\"fixed-case\" toggle=\"no\">sAPC<\/jats:styled-content>\n              s as an alternative. Flow cytometry, immunocytochemistry, and functional\/cytotoxic assays indicate that\n              <jats:styled-content style=\"fixed-case\" toggle=\"no\">sAPC<\/jats:styled-content>\n              s are a surrogate of\n              <jats:styled-content style=\"fixed-case\" toggle=\"no\">hAPC<\/jats:styled-content>\n              s. Transplantation of allogeneic\n              <jats:styled-content style=\"fixed-case\" toggle=\"no\">sAPC<\/jats:styled-content>\n              s benefited capillary density and fibrosis but did not improve cardiac magnetic resonance imaging indices of contractility. Transplanted cells were detected in the border zone.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Immunologic barriers limit the applicability of a xenogeneic swine model to assess\n              <jats:styled-content style=\"fixed-case\" toggle=\"no\">hAPC<\/jats:styled-content>\n              efficacy. On the other hand, we newly show that transplantation of allogeneic\n              <jats:styled-content style=\"fixed-case\" toggle=\"no\">sAPC<\/jats:styled-content>\n              s is feasible, safe, and immunologically acceptable. The approach induces proangiogenic and antifibrotic benefits, though these effects were not enough to result in functional improvements.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.117.006727","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T20:10:55Z","timestamp":1516651855000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":46,"title":["Transplantation of Allogeneic Pericytes Improves Myocardial Vascularization and Reduces Interstitial Fibrosis in a Swine Model of Reperfused Acute Myocardial Infarction"],"prefix":"10.1161","volume":"7","author":[{"given":"Valeria Vincenza","family":"Alvino","sequence":"first","affiliation":[{"name":"University of Bristol","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Fern\u00e1ndez\u2010Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Centro Nacional de 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