{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:56:14Z","timestamp":1788188174919,"version":"build-2803163510"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,12,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">We investigated whether cardiac parameters in young adulthood are associated with indicators of brain health in midlife.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              This study includes 648 participants from the CARDIA (Coronary Artery Risk Development in Young Adults) study (52% women, 38% black). We studied associations of cardiac parameters assessed by echocardiography (left ventricular ejection fraction, left atrial volume, and left ventricular mass) in young adulthood (mean age: 30\u00a0years) with brain measures obtained by magnetic resonance imaging (total brain, gray and white matter volume, white matter integrity, abnormal white matter) in midlife (mean age: 50\u00a0years). In 406 individuals with complete measurements, higher left atrial volume was associated with lower white matter fractional anisotropy, independent of traditional cardiovascular risk factors (\u03b2=\u22120.002;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.02). The association was strongest in black participants and in men.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Higher left atrial volume in early adulthood is associated with impairment of white matter integrity in midlife. Interventions to improve cardiac function in young adults may benefit brain health and should be targeted in particular at black men.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.117.006750","type":"journal-article","created":{"date-parts":[[2017,12,16]],"date-time":"2017-12-16T01:11:27Z","timestamp":1513386687000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Subclinical Cardiac Dysfunction and Brain Health in Midlife: CARDIA (Coronary Artery Risk Development in Young Adults) Brain Magnetic Resonance Imaging Substudy"],"prefix":"10.1161","volume":"6","author":[{"given":"Pavla","family":"Cermakova","sequence":"first","affiliation":[{"name":"Division for Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden"},{"name":"National Institute of Mental Health, Klecany, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majon","family":"Muller","sequence":"additional","affiliation":[{"name":"Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD"},{"name":"Department of Internal Medicine\u2010Section\u00a0Geriatric Medicine, VU University Medical Center, Amsterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anderson C.","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD"},{"name":"University of Sao Francisco Valley, Petrolina, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota","family":"Religa","sequence":"additional","affiliation":[{"name":"Division for Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden"},{"name":"Geriatric Clinic, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Nick","family":"Bryan","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o A. C.","family":"Lima","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenore J.","family":"Launer","sequence":"additional","affiliation":[{"name":"Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12287"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.631"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hft020"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfr138"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001289"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2016160548"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001294"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.905091"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2011.06.056"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.2.194"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.11.009"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0807265"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001264"},{"key":"e_1_3_4_15_2","unstructured":"CARDIA . CARDIA Coordinating Center. 2015. Available at: http:\/\/www.cardia.dopm.uab.edu\/contact-cardia. Accessed March 01 2015."},{"key":"e_1_3_4_16_2","unstructured":"National Heart Lung and Blood Institute . Biospecimen and Data Resources. 2015. Available at: https:\/\/biolincc.nhlbi.nih.gov\/home\/. Accessed March 01 2015."},{"key":"e_1_3_4_17_2","unstructured":"CARDIA . NHLBI Data Repository. 2015. Available at: http:\/\/www.cardia.dopm.uab.edu\/study-information\/nhlbi-data-repository-data. Accessed March 01 2015."},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(88)90080-7"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws224"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.02.048"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm605"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122138"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.10424"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4245"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2014.223"},{"key":"e_1_3_4_26_2","first-page":"47","article-title":"Correlates and predictors of weight loss in young adults: the CARDIA study","volume":"20","author":"Bild DE","year":"1996","unstructured":"Bild DE, Sholinsky P, Smith DE, Lewis CE, Hardin JM, Burke GL. Correlates and predictors of weight loss in young adults: the CARDIA study. Int J Obes Relat Metab Disord. 1996;20:47\u201355.","journal-title":"Int J Obes Relat Metab Disord"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.004798"},{"key":"e_1_3_4_28_2","first-page":"452","article-title":"Genetic studies of human apolipoproteins. IV. Structural heterogeneity of apolipoprotein H (beta 2\u2010glycoprotein I)","volume":"42","author":"Kamboh MI","year":"1988","unstructured":"Kamboh MI, Ferrell RE, Sepehrnia B. Genetic studies of human apolipoproteins. IV. Structural heterogeneity of apolipoprotein H (beta 2\u2010glycoprotein I). Am J Hum Genet. 1988;42:452\u2013457.","journal-title":"Am J Hum Genet"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.680223"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2012.10.021"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2012.8.2.123"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeu018"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.222"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.08.073"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.02.092"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.005119"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.12.007"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.117.006750","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:43:02Z","timestamp":1715596982000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.117.006750"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,2]]},"references-count":36,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12,2]]}},"alternative-id":["10.1161\/JAHA.117.006750"],"URL":"https:\/\/doi.org\/10.1161\/jaha.117.006750","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,2]]},"assertion":[{"value":"2017-05-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-10-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-12-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e006750"}}