{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T14:42:10Z","timestamp":1785940930796,"version":"3.56.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,12,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The association of short\u2010term variability of fasting plasma glucose (\n              <jats:styled-content style=\"fixed-case\">FPG<\/jats:styled-content>\n              ) and mortality has been well investigated. However, the relationships between visit\u2010to\u2010visit variability of\n              <jats:styled-content style=\"fixed-case\">FPG<\/jats:styled-content>\n              over longer periods of follow\u2010up and cardiovascular disease (\n              <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>\n              ) and all\u2010cause mortality are unclear. This study aimed to investigate these relationships.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The current analysis included 53\u00a0607 Chinese participants (mean age, 49.10\u00a0years) who were free of\n              <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>\n              in the Kailuan study. Participants were divided into 4 categories by quartiles of visit\u2010to\u2010visit variability of\n              <jats:styled-content style=\"fixed-case\">FPG<\/jats:styled-content>\n              . Visit\u2010to\u2010visit variability of\n              <jats:styled-content style=\"fixed-case\">FPG<\/jats:styled-content>\n              was defined as the coefficient of variation of 3 values of\n              <jats:styled-content style=\"fixed-case\">FPG<\/jats:styled-content>\n              that were measured from the examination periods of 2006 to 2007, 2008 to 2009, and 2010 to 2011. Cox proportional hazards models were used to calculate hazard ratios and 95% confidence intervals for\n              <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>\n              and all\u2010cause mortality. After a mean follow\u2010up of 4.93\u00a0years, 4261 individuals developed\n              <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>\n              and 1545 individuals died. The incidence of\n              <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>\n              and all\u2010cause mortality was 5.04 and 5.85 per 1000 person\u2010years, respectively. After adjusting for mean\n              <jats:styled-content style=\"fixed-case\">FPG<\/jats:styled-content>\n              and other potential confounders, individuals in the highest quartile of variability of\n              <jats:styled-content style=\"fixed-case\">FPG<\/jats:styled-content>\n              compared with participants in the lowest quartile showed a 26% greater risk of developing\n              <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>\n              (hazard ratio, 1.26; 95% confidence interval, 1.08\u20131.47) and a 46% greater risk for all\u2010cause mortality (hazard ratio, 1.46; 95% confidence interval, 1.25\u20131.70).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Independent of mean\n              <jats:styled-content style=\"fixed-case\">FPG<\/jats:styled-content>\n              and other baseline parameters, elevated visit\u2010to\u2010visit variability of\n              <jats:styled-content style=\"fixed-case\">FPG<\/jats:styled-content>\n              significantly increases the risk of\n              <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>\n              and all\u2010cause mortality in the general population. Measuring long\u2010term visit\u2010to\u2010visit variability of\n              <jats:styled-content style=\"fixed-case\">FPG<\/jats:styled-content>\n              is helpful for predicting the risk for\n              <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>\n              and all\u2010cause mortality.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.117.006757","type":"journal-article","created":{"date-parts":[[2017,11,30]],"date-time":"2017-11-30T01:10:10Z","timestamp":1512004210000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":66,"title":["Visit\u2010to\u2010Visit Variability of Fasting Plasma Glucose and the Risk of Cardiovascular Disease and All\u2010Cause Mortality in the General Population"],"prefix":"10.1161","volume":"6","author":[{"given":"Anxin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"},{"name":"Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing, China"},{"name":"Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China"},{"name":"Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxue","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tangshan People's Hospital, North China University of Science and Technology, Tangshan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing, China"},{"name":"Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China"},{"name":"Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochen","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Tangshan People's Hospital, North China University of Science and Technology, Tangshan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoping","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing, China"},{"name":"Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China"},{"name":"Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuohua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kailuan Hospital, North China University of Science and Technology, Tangshan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing, China"},{"name":"Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China"},{"name":"Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouling","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kailuan Hospital, North China University of Science and Technology, 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