{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T20:59:59Z","timestamp":1793825999627,"version":"4.6.1"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,12,2]]},"abstract":"\n Background<\/jats:title>\n \n Clinical decision making in abdominal aortic aneurysms (AAA) relies completely on diameter. At this point, improved decision tools remain an unmet medical need. Our goal was to identify changes at the molecular level specifically leading up to\n AAA<\/jats:styled-content>\n rupture.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Aortic wall tissue specimens were collected during open elective (e\n AAA<\/jats:styled-content>\n ; n=31) or emergency repair of ruptured\n AAA<\/jats:styled-content>\n (r\n AAA<\/jats:styled-content>\n ; n=17), and gene expression was investigated using microarrays. Identified candidate genes were validated with quantitative real\u2010time polymerase chain reaction in an independent sample set (e\n AAA<\/jats:styled-content>\n : n=46; r\n AAA<\/jats:styled-content>\n : n=18). Two gene sets were identified, 1 set containing 5 genes linked to terminal progression, that is, positively associated with progression of larger\n AAA<\/jats:styled-content>\n , and with rupture (\n \n HILPDA<\/jats:styled-content>\n <\/jats:italic>\n ,\n \n ANGPTL<\/jats:styled-content>\n 4\n <\/jats:italic>\n ,\n \n LOX<\/jats:styled-content>\n <\/jats:italic>\n ,\n \n SRPX<\/jats:styled-content>\n 2\n <\/jats:italic>\n ,\n \n FCGBP<\/jats:styled-content>\n <\/jats:italic>\n ), and a second set containing 5 genes exclusively upregulated in\n rAAA<\/jats:styled-content>\n (\n \n ADAMTS<\/jats:styled-content>\n 9\n <\/jats:italic>\n ,\n \n STC<\/jats:styled-content>\n 1\n <\/jats:italic>\n ,\n \n GFPT<\/jats:styled-content>\n 2\n <\/jats:italic>\n ,\n \n GAL<\/jats:styled-content>\n 3\n ST<\/jats:styled-content>\n 4\n <\/jats:italic>\n ,\n \n CCL<\/jats:styled-content>\n 4L1\n <\/jats:italic>\n ). Genes in both sets essentially associated with processes related to impaired tissue remodeling, such as angiogenesis and adipogenesis. In gene expression experiments we were able to show that upregulated gene expression for identified candidate genes is unique for\n AAA<\/jats:styled-content>\n . Functionally, the selected upregulated factors converge at processes coordinated by the canonical\n HIF<\/jats:styled-content>\n \u20101\u03b1 signaling pathway and are highly expressed in fibroblasts but not inflammatory cells of the aneurysmatic wall. Histological quantification of angiogenesis and exploration of the\n HIF<\/jats:styled-content>\n \u20101\u03b1 network in r\n AAA<\/jats:styled-content>\n versus e\n AAA<\/jats:styled-content>\n shows enhanced microvessel density but also clear activation of the\n HIF<\/jats:styled-content>\n \u20101\u03b1 network in r\n AAA<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Our study shows a specific molecular fingerprint for terminal\n AAA<\/jats:styled-content>\n disease. These changes appear to converge at activation of\n HIF<\/jats:styled-content>\n \u20101\u03b1 signaling in mesenchymal cells. Aspects of this cascade might represent targets for rupture risk assessment.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.117.006798","type":"journal-article","created":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T01:10:13Z","timestamp":1512090613000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":70,"title":["Molecular Fingerprint for Terminal Abdominal Aortic Aneurysm Disease"],"prefix":"10.1161","volume":"6","author":[{"given":"Gabor","family":"G\u00e4bel","sequence":"first","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, Ludwig\u2010Maximilians\u2010University Munich, Munich, Germany"},{"name":"Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd H.","family":"Northoff","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Medicine, Ludwig\u2010Maximilians\u2010University Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Weinzierl","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, Ludwig\u2010Maximilians\u2010University Munich, Munich, Germany"},{"name":"Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Ludwig","sequence":"additional","affiliation":[{"name":"Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Hinterseher","sequence":"additional","affiliation":[{"name":"Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden, Dresden, Germany"},{"name":"Department of General, Visceral, Vascular and Thoracic Surgery, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Wilfert","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Medicine, Ludwig\u2010Maximilians\u2010University Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Teupser","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Medicine, Ludwig\u2010Maximilians\u2010University Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan A.","family":"Doderer","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik","family":"Bergert","sequence":"additional","affiliation":[{"name":"Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden, Dresden, Germany"},{"name":"Vascular and Endovascular Surgery, HELIOS Clinic Erfurt, Erfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Sch\u00f6nleben","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, Ludwig\u2010Maximilians\u2010University Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan H. 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