{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:06:53Z","timestamp":1788566813007,"version":"build-2803163510"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,10,11]]},"abstract":"\n Background<\/jats:title>\n \n The effects of monthly, high\u2010dose, long\u2010term (\u22651\u2010year) vitamin D supplementation on central blood pressure (\n BP<\/jats:styled-content>\n ) parameters are unknown.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n A total of 517 adults (58% male, aged 50\u201384\u00a0years) were recruited into a double\u2010blinded, placebo\u2010controlled trial substudy and randomized to receive, for 1.1\u00a0years (median; range: 0.9\u20131.5\u00a0years), either (1) vitamin D\n 3<\/jats:sub>\n 200\u00a0000\u00a0IU (initial dose) followed 1 month later by monthly 100\u00a0000\u2010IU doses (n=256) or (2) placebo monthly (n=261). At baseline (n=517) and follow\u2010up (n=380), suprasystolic oscillometry was undertaken, yielding aortic\n BP<\/jats:styled-content>\n waveforms and hemodynamic parameters. Mean deseasonalized 25\u2010hydroxyvitamin D increased from 66 nmol\/L (SD: 24) at baseline to 122 nmol\/L (SD: 42) at follow\u2010up in the vitamin D group, with no change in the placebo group. Despite small, nonsignificant changes in hemodynamic parameters in the total sample (primary outcome), we observed consistently favorable changes among the 150 participants with vitamin D deficiency (<50\u00a0nmol\/L) at baseline. In this subgroup, mean changes in the vitamin D group (n=71) versus placebo group (n=79) were \u22125.3 mm\u00a0Hg (95% confidence interval [CI], \u221211.8 to 1.3) for brachial systolic\n BP<\/jats:styled-content>\n (\n P<\/jats:italic>\n =0.11), \u22122.8 mm\u00a0Hg (95% CI, \u22126.2 to 0.7) for brachial diastolic\n BP<\/jats:styled-content>\n (\n P<\/jats:italic>\n =0.12), \u22127.5 mm\u00a0Hg (95% CI, \u221214.4 to \u22120.6) for aortic systolic\n BP<\/jats:styled-content>\n (\n P<\/jats:italic>\n =0.03), \u22125.7 mm\u00a0Hg (95% CI, \u221210.8 to \u22120.6) for augmentation index (\n P<\/jats:italic>\n =0.03), \u22120.3 m\/s (95% CI, \u22120.6 to \u22120.1) for pulse wave velocity (\n P<\/jats:italic>\n =0.02), \u22128.6 mm\u00a0Hg (95% CI, \u221215.4 to \u22121.9) for peak reservoir pressure (\n P<\/jats:italic>\n =0.01), and \u22123.6 mm\u00a0Hg (95% CI, \u22126.3 to \u22120.8) for backward pressure amplitude (\n P<\/jats:italic>\n =0.01).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Monthly, high\u2010dose, 1\u2010year vitamin D supplementation lowered central\n BP<\/jats:styled-content>\n parameters among adults with vitamin D deficiency but not in the total sample.\n <\/jats:p>\n <\/jats:sec>\n \n Clinical Trial Registration<\/jats:title>\n \n URL<\/jats:styled-content>\n :\n http:\/\/www.anzctr.org.au<\/jats:ext-link>\n . Unique identifier:\n ACTRN<\/jats:styled-content>\n 12611000402943.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.117.006802","type":"journal-article","created":{"date-parts":[[2017,10,25]],"date-time":"2017-10-25T00:10:34Z","timestamp":1508890234000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":79,"title":["Effect of Monthly, High\u2010Dose, Long\u2010Term Vitamin D Supplementation on Central Blood Pressure Parameters: A Randomized Controlled Trial Substudy"],"prefix":"10.1161","volume":"6","author":[{"given":"John D.","family":"Sluyter","sequence":"first","affiliation":[{"name":"School of Population Health, University of Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Carlos A.","family":"Camargo","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alistair W.","family":"Stewart","sequence":"additional","affiliation":[{"name":"School of Population Health, University of Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debbie","family":"Waayer","sequence":"additional","affiliation":[{"name":"School of Population Health, University of Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlene M. 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