{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:46:36Z","timestamp":1791254796928,"version":"4.1.0"},"reference-count":55,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,10,11]]},"abstract":"\n Background<\/jats:title>\n \n Time in the therapeutic range (\n TTR<\/jats:styled-content>\n ) is associated with the effectiveness and safety of vitamin K antagonist (\n VKA<\/jats:styled-content>\n ) therapy. To optimize prescribing of\n VKA<\/jats:styled-content>\n , we aimed to develop and validate a prediction model for\n TTR<\/jats:styled-content>\n in older adults taking\n VKA<\/jats:styled-content>\n for nonvalvular atrial fibrillation and venous thromboembolism.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n The study cohort comprised patients aged \u226565 years who were taking\n VKA<\/jats:styled-content>\n for atrial fibrillation or venous thromboembolism and who were identified in the 2\n US<\/jats:styled-content>\n electronic health record databases linked with Medicare claims data from 2007 through 2014. With the predictors identified from a systematic review and clinical knowledge, we built a prediction model for\n TTR<\/jats:styled-content>\n , using one electronic health record system as the training set and the other as the validation set. We compared the performance of the new models to that of a published prediction score for\n TTR<\/jats:styled-content>\n ,\n SAM<\/jats:styled-content>\n e\u2010\n TT<\/jats:styled-content>\n 2<\/jats:sub>\n R\n 2<\/jats:sub>\n . Based on 1663 patients in the training set and 1181 in the validation set, our optimized score included 42 variables and the simplified model included 7 variables, abbreviated as\n PROSPER<\/jats:styled-content>\n (Pneumonia, Renal dysfunction, Oozing blood [prior bleeding], Staying in hospital \u22657\u00a0days, Pain medication use, no Enhanced [structured] anticoagulation services, Rx for antibiotics). The\n PROSPER<\/jats:styled-content>\n score outperformed\n SAM<\/jats:styled-content>\n e\u2010\n TT<\/jats:styled-content>\n 2<\/jats:sub>\n R\n 2<\/jats:sub>\n when predicting both\n TTR<\/jats:styled-content>\n \u226570% (area under the receiver operating characteristic curve 0.67 versus 0.55) and the thromboembolic and bleeding outcomes (area under the receiver operating characteristic curve 0.62 versus 0.52).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Our geriatric\n TTR<\/jats:styled-content>\n score can be used as a clinical decision aid to select appropriate candidates to receive\n VKA<\/jats:styled-content>\n therapy and as a research tool to address confounding and treatment effect heterogeneity by anticoagulation quality.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.117.006814","type":"journal-article","created":{"date-parts":[[2017,10,6]],"date-time":"2017-10-06T00:10:26Z","timestamp":1507248626000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":33,"title":["Prediction Score for Anticoagulation Control Quality Among Older Adults"],"prefix":"10.1161","volume":"6","author":[{"given":"Kueiyu Joshua","family":"Lin","sequence":"first","affiliation":[{"name":"Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA"},{"name":"Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA"},{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel E.","family":"Singer","sequence":"additional","affiliation":[{"name":"Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA"},{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Glynn","sequence":"additional","affiliation":[{"name":"Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA"},{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Blackley","sequence":"additional","affiliation":[{"name":"Clinical and Quality Analysis, Information Systems, Partners HealthCare System, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA"},{"name":"Clinical Informatics, Partners eCare, Partners HealthCare System, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina","family":"Dube","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn B.","family":"Oertel","sequence":"additional","affiliation":[{"name":"Anticoagulation Management Service, Department of Nursing, Massachusetts General Hospital, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Schneeweiss","sequence":"additional","affiliation":[{"name":"Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA"},{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0670"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-12-200706190-00007"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.11.061"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2014.01.013"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.115.001768"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.750000"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.006476"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.108.830232"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1107039"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0905561"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009638"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61194-4"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2014.5398"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.012061"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2016-310358"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2010.03.010"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-0054"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2015.06.007"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-014-2784-2"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.002601"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.113.000817"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH14-09-0754"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-2976"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2014.05.023"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-2109"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2006.pto_368.x"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3334"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.10.004"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3697"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1651587"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.20.2685"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1996.tb02080.x"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4323"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.114.000804"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.108.796185"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.2307\/2531595"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001888-199908000-00012"},{"key":"e_1_3_4_39_2","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.2517-6161.1964.tb00553.x","article-title":"An analysis of transformations revisited","volume":"26","author":"Box GEP","year":"1964","unstructured":"Box GEP, Cox DR. An analysis of transformations revisited. J R Stat Soc. 1964;26:211\u2013252.","journal-title":"J R Stat Soc"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1368-5031.2006.00790.x"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2013.09.003"},{"key":"e_1_3_4_42_2","first-page":"494","article-title":"Analysis of factors affecting time in therapeutic range control after warfarin administration","volume":"70","author":"Kose E","year":"2015","unstructured":"Kose E, Arai S, An T, Kikkawa A, Aoyama T, Matsumoto Y, Hayashi H. Analysis of factors affecting time in therapeutic range control after warfarin administration. Pharmazie. 2015;70:494\u2013498.","journal-title":"Pharmazie"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40256-015-0120-9"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv127"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0000000000000397"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2015.09.047"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.03996.x"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113627"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH14-12-1033"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1080\/00222895.1984.10735324"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1089\/dis.2006.9.201"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1592\/phco.30.4.330"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-44462"},{"key":"e_1_3_4_54_2","first-page":"16","article-title":"Comparison of anticoagulation clinic patient outcomes with outcomes from traditional care in a family medicine clinic","volume":"14","author":"Chamberlain MA","year":"2001","unstructured":"Chamberlain MA, Sageser NA, Ruiz D. Comparison of anticoagulation clinic patient outcomes with outcomes from traditional care in a family medicine clinic. J Am Board Fam Pract. 2001;14:16\u201321.","journal-title":"J Am Board Fam Pract"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-0134"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.359"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.117.006814","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:50:38Z","timestamp":1715597438000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.117.006814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,11]]},"references-count":55,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10,11]]}},"alternative-id":["10.1161\/JAHA.117.006814"],"URL":"https:\/\/doi.org\/10.1161\/jaha.117.006814","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,11]]},"assertion":[{"value":"2017-05-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-08-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-10-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e006814"}}