{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T20:52:27Z","timestamp":1776286347668,"version":"3.50.1"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,1,9]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In our practice, we noticed an increased frequency of tracheobronchial branching abnormalities (\n              <jats:styled-content style=\"fixed-case\">TBA<\/jats:styled-content>\n              s) in patients with tetralogy of Fallot (ToF). This study aimed to determine whether an association exists between congenital\n              <jats:styled-content style=\"fixed-case\">TBA<\/jats:styled-content>\n              s and ToF with or without pulmonary atresia.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The frequency of\n              <jats:styled-content style=\"fixed-case\">TBA<\/jats:styled-content>\n              s on chest computed tomography was assessed in 55 patients with ToF without pulmonary atresia, 34 patients with ToF with pulmonary arteria, and 100 control patients. We then looked for a possible association between\n              <jats:styled-content style=\"fixed-case\">TBA<\/jats:styled-content>\n              s and pulmonary artery branch hypoplasia, the presence of major aortopulmonary collateral arteries, and the presence of the chromosome 22q11 deletion.\n              <jats:styled-content style=\"fixed-case\">TBA<\/jats:styled-content>\n              s were significantly more frequent in patients with ToF with or without pulmonary atresia than in the control group (any\n              <jats:styled-content style=\"fixed-case\">TBA<\/jats:styled-content>\n              s, 21% versus 2% [\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001]; bronchial situs anomalies, 6% versus 0% [\n              <jats:italic>P<\/jats:italic>\n              =0.002]; right tracheal bronchus, 4% versus 0% [\n              <jats:italic>P<\/jats:italic>\n              =0.04]; left eparterial bronchus, 8% versus 0% [\n              <jats:italic>P<\/jats:italic>\n              =0.005]); and tended to be more frequent in those with ToF without pulmonary atresia than in those with ToF with pulmonary atresia (any\n              <jats:styled-content style=\"fixed-case\">TBA<\/jats:styled-content>\n              s, 27% versus 12% [\n              <jats:italic>P<\/jats:italic>\n              =0.11]; left eparterial bronchus, 13% versus 0% [\n              <jats:italic>P<\/jats:italic>\n              =0.04]).\n              <jats:styled-content style=\"fixed-case\">TBA<\/jats:styled-content>\n              s were readily multiple (8 patients of 19 with\n              <jats:styled-content style=\"fixed-case\">TBA<\/jats:styled-content>\n              ) and concerned essentially the upper lobes.\n              <jats:styled-content style=\"fixed-case\">TBA<\/jats:styled-content>\n              s were not associated with pulmonary branch hypoplasia, major aortopulmonary collateral arteries, or the chromosome 22q11 deletion.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">We demonstrated a significantly increased frequency of tracheobronchial abnormalities in patients with ToF with or without pulmonary atresia compared with a control group. These results suggest an interaction between abnormalities in conotruncal septation and tracheobronchial branching and may provide a new clue to the pathogenesis of conotruncal heart diseases.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.117.006921","type":"journal-article","created":{"date-parts":[[2017,12,30]],"date-time":"2017-12-30T01:10:31Z","timestamp":1514596231000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Association Between Tetralogy of Fallot and Tracheobronchial Branching Abnormalities: A New Clue for Pathogenesis?"],"prefix":"10.1161","volume":"7","author":[{"given":"Guillaume","family":"Chassagnon","sequence":"first","affiliation":[{"name":"Radiology Department, H\u00f4pital Clocheville, Universit\u00e9 Fran\u00e7ois Rabelais de Tours, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Lefort","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology Department, H\u00f4pital Clocheville, Universit\u00e9 Fran\u00e7ois Rabelais de Tours, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathilde","family":"Meot","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology Department, H\u00f4pital Clocheville, Universit\u00e9 Fran\u00e7ois Rabelais de Tours, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elodie","family":"Carpentier","sequence":"additional","affiliation":[{"name":"Radiology Department, H\u00f4pital Clocheville, Universit\u00e9 Fran\u00e7ois Rabelais de Tours, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Sirinelli","sequence":"additional","affiliation":[{"name":"Radiology Department, H\u00f4pital Clocheville, Universit\u00e9 Fran\u00e7ois Rabelais de Tours, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Chantepie","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology Department, H\u00f4pital Clocheville, Universit\u00e9 Fran\u00e7ois Rabelais de Tours, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baptiste","family":"Morel","sequence":"additional","affiliation":[{"name":"Radiology Department, H\u00f4pital Clocheville, Universit\u00e9 Fran\u00e7ois Rabelais de Tours, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.08.025"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60657-7"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-4-2"},{"key":"e_1_3_3_5_2","first-page":"434","article-title":"Surgery of congenital heart diseases","volume":"2","author":"Taussig H","year":"1947","unstructured":"Taussig H, Blalock A. 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