{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T13:46:22Z","timestamp":1780667182148,"version":"3.54.1"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In US clinical practice, many patients who undergo placement of an implantable cardioverter\u2010defibrillator (\n              <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>\n              ) for primary prevention of sudden cardiac death receive dual\u2010chamber devices. The superiority of dual\u2010chamber over single\u2010chamber devices in reducing the risk of inappropriate\n              <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>\n              shocks in clinical practice has not been established. The objective of this study was to compare risk of adverse outcomes, including inappropriate shocks, between single\u2010 and dual\u2010chamber\n              <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>\n              s for primary prevention.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We identified patients receiving a single\u2010 or dual\u2010chamber\n              <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>\n              for primary prevention who did not have an indication for pacing from 15 hospitals within 7 integrated health delivery systems in the Longitudinal Study of Implantable Cardioverter\u2010Defibrillators from 2006 to 2009. The primary outcome was time to first inappropriate shock.\n              <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>\n              shocks were adjudicated for appropriateness. Other outcomes included all\u2010cause hospitalization, heart failure hospitalization, and death. Patient, clinician, and hospital\u2010level factors were accounted for using propensity score weighting methods. Among 1042 patients without pacing indications, 54.0% (n=563) received a single\u2010chamber device and 46.0% (n=479) received a dual\u2010chamber device. In a propensity\u2010weighted analysis, device type was not significantly associated with inappropriate shock (hazard ratio, 0.91; 95% confidence interval, 0.59\u20131.38 [\n              <jats:italic>P<\/jats:italic>\n              =0.65]), all\u2010cause hospitalization (hazard ratio, 1.03; 95% confidence interval, 0.87\u20131.21 [\n              <jats:italic>P<\/jats:italic>\n              =0.76]), heart failure hospitalization (hazard ratio, 0.93; 95% confidence interval, 0.72\u20131.21 [\n              <jats:italic>P<\/jats:italic>\n              =0.59]), or death (hazard ratio, 1.19; 95% confidence interval, 0.93\u20131.53 [\n              <jats:italic>P<\/jats:italic>\n              =0.17]).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Among patients who received an\n              <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>\n              for primary prevention without indications for pacing, dual\u2010chamber devices were not associated with lower risk of inappropriate shock or differences in hospitalization or death compared with single\u2010chamber devices. This study does not justify the use of dual\u2010chamber devices to minimize inappropriate shocks.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.117.006937","type":"journal-article","created":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T01:10:22Z","timestamp":1510276222000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":29,"title":["Comparison of Inappropriate Shocks and Other Health Outcomes Between Single\u2010 and Dual\u2010Chamber Implantable Cardioverter\u2010Defibrillators for Primary Prevention of Sudden Cardiac Death: Results From the Cardiovascular Research Network Longitudinal Study of Implantable Cardioverter\u2010Defibrillators"],"prefix":"10.1161","volume":"6","author":[{"given":"Pamela N.","family":"Peterson","sequence":"first","affiliation":[{"name":"Denver Health Medical Center, Denver, CO"},{"name":"University of Colorado Denver Anschutz Medical Campus, Aurora, CO"},{"name":"Institute for Health Research, Kaiser Permanente Colorado, Denver, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert T.","family":"Greenlee","sequence":"additional","affiliation":[{"name":"Marshfield Clinic Research Foundation, Marshfield, WI"},{"name":"Marshfield Clinic, Marshfield, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan S.","family":"Go","sequence":"additional","affiliation":[{"name":"Division of Research, Kaiser Permanente Northern California, Oakland, CA"},{"name":"University of California San Francisco, San Francisco, CA"},{"name":"Stanford University School of Medicine, Palo Alto, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Magid","sequence":"additional","affiliation":[{"name":"University of Colorado Denver Anschutz Medical Campus, Aurora, CO"},{"name":"Institute for Health Research, Kaiser Permanente Colorado, Denver, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Cassidy\u2010Bushrow","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romel","family":"Garcia\u2010Montilla","sequence":"additional","affiliation":[{"name":"Marshfield Clinic Research Foundation, Marshfield, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen A.","family":"Glenn","sequence":"additional","affiliation":[{"name":"Institute for Health Research, Kaiser Permanente Colorado, Denver, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry H.","family":"Gurwitz","sequence":"additional","affiliation":[{"name":"Meyers Primary Care Institute, Worcester, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen C.","family":"Hammill","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Hayes","sequence":"additional","affiliation":[{"name":"Marshfield Clinic Research Foundation, Marshfield, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Kadish","sequence":"additional","affiliation":[{"name":"Touro College, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristi","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Southern California Department of Research and Evaluation, Pasadena, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Param","family":"Sharma","sequence":"additional","affiliation":[{"name":"Marshfield Clinic Research Foundation, Marshfield, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Smith","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Northwest Center for Health Research, Portland, OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul D.","family":"Varosy","sequence":"additional","affiliation":[{"name":"University of Colorado Denver Anschutz Medical Campus, Aurora, CO"},{"name":"Institute for Health Research, Kaiser Permanente Colorado, Denver, CO"},{"name":"Eastern Colorado VA Health Care System, Denver, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humberto","family":"Vidaillet","sequence":"additional","affiliation":[{"name":"Marshfield Clinic Research Foundation, Marshfield, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan X.","family":"Zeng","sequence":"additional","affiliation":[{"name":"Institute for Health Research, Kaiser Permanente Colorado, Denver, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon\u2010Lise T.","family":"Normand","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Boston, MA"},{"name":"Harvard School of Public Health, 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