{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:36:18Z","timestamp":1792442178262,"version":"4.5.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,10,11]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Microvascular injury (\n              <jats:styled-content style=\"fixed-case\">MVI<\/jats:styled-content>\n              ) after primary percutaneous coronary intervention for\n              <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>\n              \u2010elevation myocardial infarction (\n              <jats:styled-content style=\"fixed-case\">STEMI<\/jats:styled-content>\n              ) is a major determinant of adverse clinical outcome. Experimental data indicate an impact of hypercholesterolemia on\n              <jats:styled-content style=\"fixed-case\">MVI<\/jats:styled-content>\n              ; however, there is a lack of clinical studies confirming this relation. We aimed to investigate the association of cholesterol concentrations on admission with\n              <jats:styled-content style=\"fixed-case\">MVI<\/jats:styled-content>\n              visualized by cardiac magnetic resonance imaging and clinical outcome in\n              <jats:styled-content style=\"fixed-case\">STEMI<\/jats:styled-content>\n              patients treated by primary percutaneous coronary intervention.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In this prospective, observational study, we included 235 consecutive revascularized\n              <jats:styled-content style=\"fixed-case\">STEMI<\/jats:styled-content>\n              patients. Cholesterol (total cholesterol, low\u2010density lipoprotein [\n              <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>\n              ], and high\u2010density lipoprotein cholesterol) and triglyceride concentrations were determined at presentation. Cardiac magnetic resonance scans were performed 2 (2\u20134) days after infarction to assess infarct characteristics, including\n              <jats:styled-content style=\"fixed-case\">MVI<\/jats:styled-content>\n              . Clinical end point was the occurrence of major adverse cardiac events (\n              <jats:styled-content style=\"fixed-case\">MACE<\/jats:styled-content>\n              ) comprising all\u2010cause mortality, nonfatal reinfarction, and new congestive heart failure. Patients with\n              <jats:styled-content style=\"fixed-case\">MVI<\/jats:styled-content>\n              (n=129; 55%) showed higher levels of total cholesterol (204 [172\u2013226] versus 185 [168\u2013212] mg\/dL;\n              <jats:italic>P<\/jats:italic>\n              =0.01) and\n              <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>\n              cholesterol (142 [113\u2013166] versus 118 [103\u2013149] mg\/dL;\n              <jats:italic>P<\/jats:italic>\n              =0.001), whereas high\u2010density lipoprotein cholesterol and triglycerides did not differ significantly. In multivariable analysis, including all significant clinical and cardiac magnetic resonance determinants of\n              <jats:styled-content style=\"fixed-case\">MVI<\/jats:styled-content>\n              ,\n              <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>\n              concentration emerged as an independent predictor of\n              <jats:styled-content style=\"fixed-case\">MVI<\/jats:styled-content>\n              (odds ratio, 1.02 [95% confidence interval, 1.01\u20131.02];\n              <jats:italic>P<\/jats:italic>\n              =0.002). Furthermore, increased\n              <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>\n              cholesterol (&gt;150\u00a0mg\/dL) significantly predicted the occurrence of major adverse cardiac events (hazard ratio, 3.09 [95% confidence interval, 1.22\u20137.87];\n              <jats:italic>P<\/jats:italic>\n              =0.01).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In\n              <jats:styled-content style=\"fixed-case\">STEMI<\/jats:styled-content>\n              patients undergoing primary percutaneous coronary intervention, baseline\n              <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>\n              cholesterol concentrations were independently associated with\n              <jats:styled-content style=\"fixed-case\">MVI<\/jats:styled-content>\n              , revealing a clinically relevant link between\n              <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>\n              metabolism and\n              <jats:styled-content style=\"fixed-case\">MVI<\/jats:styled-content>\n              in acute\n              <jats:styled-content style=\"fixed-case\">STEMI<\/jats:styled-content>\n              .\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.117.006957","type":"journal-article","created":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T00:10:58Z","timestamp":1507680658000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":52,"title":["Relation of Low\u2010Density Lipoprotein Cholesterol With Microvascular Injury and Clinical Outcome in Revascularized ST\u2010Elevation Myocardial Infarction"],"prefix":"10.1161","volume":"6","author":[{"given":"Martin","family":"Reindl","sequence":"first","affiliation":[{"name":"University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian Johannes","family":"Reinstadler","sequence":"additional","affiliation":[{"name":"University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans\u2010Josef","family":"Feistritzer","sequence":"additional","affiliation":[{"name":"University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Theurl","sequence":"additional","affiliation":[{"name":"University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Basic","sequence":"additional","affiliation":[{"name":"University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Eigler","sequence":"additional","affiliation":[{"name":"University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Holzknecht","sequence":"additional","affiliation":[{"name":"University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Mair","sequence":"additional","affiliation":[{"name":"University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"Mayr","sequence":"additional","affiliation":[{"name":"University Clinic of Radiology, Medical University of Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gert","family":"Klug","sequence":"additional","affiliation":[{"name":"University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Metzler","sequence":"additional","affiliation":[{"name":"University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, 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