{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T09:43:49Z","timestamp":1784627029043,"version":"3.55.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,10,11]]},"abstract":"\n Background<\/jats:title>\n \n The safety of testosterone supplements in men remains unclear. In the present study, we tested the hypothesis that in young and old male spontaneously hypertensive rats (\n SHR)<\/jats:styled-content>\n , long\u2010term testosterone supplements increase blood pressure and that the mechanism is mediated in part by activation of the renin\u2010angiotensin system.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n In untreated males, serum testosterone exhibited a sustained decrease after 5\u00a0months of age, reaching a nadir by 18 to 22\u00a0months of age. The reductions in serum testosterone were accompanied by an increase in body weight until very old age (18\u00a0months). Testosterone supplements were given for 6\u00a0weeks to young (12\u00a0weeks\u2010\n YMSHR<\/jats:styled-content>\n ) and old (21\u201322\u00a0months\u2010\n OMSHR<\/jats:styled-content>\n ) male\n SHR<\/jats:styled-content>\n that increased serum testosterone by 2\u2010fold in young males and by 4\u2010fold in old males. Testosterone supplements decreased body weight, fat mass, lean mass, and plasma leptin, and increased plasma estradiol in\n YMSHR<\/jats:styled-content>\n but had no effect in\n OMSHR<\/jats:styled-content>\n . Mean arterial pressure (\n MAP<\/jats:styled-content>\n ) was significantly higher in\n OMSHR<\/jats:styled-content>\n than in\n YMSHR<\/jats:styled-content>\n and testosterone supplements decreased\n MAP<\/jats:styled-content>\n in\n OMSHR<\/jats:styled-content>\n , but significantly increased\n MAP<\/jats:styled-content>\n in\n YMSHR<\/jats:styled-content>\n . Enalapril, the angiotensin\u2010converting enzyme inhibitor, reduced\n MAP<\/jats:styled-content>\n in both control and testosterone\u2010supplemented\n YMSHR<\/jats:styled-content>\n , but had a greater effect on\n MAP<\/jats:styled-content>\n in testosterone\u2010treated rats, suggesting the mechanism responsible for the increase in\n MAP<\/jats:styled-content>\n in\n YMSHR<\/jats:styled-content>\n is mediated at least in part by activation of the renin\u2010angiotensin system.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Taken together with previous studies, these data suggest that testosterone supplements may have differential\u00a0effects on men depending on age, cardiovascular and metabolic status, and dose and whether given long\u2010term or short\u2010term.<\/jats:p>\n 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Jackson, MS"},{"name":"Department of Women's Health Research Center, University of Mississippi Medical Center, Jackson, MS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Licy L.","family":"Yanes Cardozo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Mississippi Medical Center, Jackson, MS"},{"name":"Department of Medicine, Divisions of Endocrinology\/Nephrology, University of Mississippi Medical Center, Jackson, MS"},{"name":"Department of Women's Health Research Center, University of Mississippi Medical Center, Jackson, MS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damian G.","family":"Romero","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Mississippi Medical Center, Jackson, MS"},{"name":"Department of Women's Health Research Center, University of Mississippi Medical Center, Jackson, MS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo 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