{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:00:49Z","timestamp":1791925249255,"version":"4.3.4"},"reference-count":77,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,1,9]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Adverse pregnancy outcomes, such as preterm birth (\n              <jats:styled-content style=\"fixed-case\">PTB<\/jats:styled-content>\n              ), have been associated with elevated risk of maternal cardiovascular disease, but their effect on late midlife blood pressure (BP) and subclinical vascular measures remains understudied.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We conducted a cross\u2010sectional analysis with 1220 multiethnic parous women enrolled in SWAN (Study of Women's Health Across the Nation) to evaluate the impact of self\u2010reported history of adverse pregnancy outcomes (\n              <jats:styled-content style=\"fixed-case\">PTB<\/jats:styled-content>\n              , small\u2010for\u2010gestational\u2010age, stillbirth), on maternal\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              , mean arterial pressure, and subclinical vascular measures (carotid intima\u2010media thickness, plaque, and pulse wave velocity) in late midlife. We also examined whether these associations were modified by race\/ethnicity. Associations were tested in linear and logistic regression models adjusting for sociodemographics, reproductive factors, cardiovascular risk factors, and medications. Women were on average aged 60\u00a0years and 255 women reported a history of an adverse pregnancy outcome. In fully adjusted models, history of\n              <jats:styled-content style=\"fixed-case\">PTB<\/jats:styled-content>\n              was associated with higher\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              (systolic: \u03b2=6.40;\n              <jats:styled-content style=\"fixed-case\">SE,<\/jats:styled-content>\n              1.62 [\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001] and diastolic: \u03b2=3.18;\n              <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>\n              , 0.98 [\n              <jats:italic>P<\/jats:italic>\n              =0.001]) and mean arterial pressure (\u03b2=4.55;\n              <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>\n              1.13 [\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001]).\n              <jats:styled-content style=\"fixed-case\">PTB<\/jats:styled-content>\n              was associated with lower intima\u2010media thickness, but not after excluding women with prevalent hypertension. There were no significant associations with other subclinical vascular measures.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Findings suggest that history of\n              <jats:styled-content style=\"fixed-case\">PTB<\/jats:styled-content>\n              is associated with higher\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              and mean arterial pressure in late midlife. Adverse pregnancy outcomes were not significantly related to subclinical cardiovascular disease when excluding women with prevalent hypertension. Future studies across the menopause transition may be important to assess the impact of adverse pregnancy outcomes on midlife progression of\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              .\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.117.007138","type":"journal-article","created":{"date-parts":[[2017,12,30]],"date-time":"2017-12-30T01:10:31Z","timestamp":1514596231000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["History of Adverse Pregnancy Outcomes, Blood Pressure, and Subclinical Vascular Measures in Late Midlife: SWAN (Study of Women's Health Across the Nation)"],"prefix":"10.1161","volume":"7","author":[{"given":"Yamnia I.","family":"Cort\u00e9s","sequence":"first","affiliation":[{"name":"Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet M.","family":"Catov","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics, Gynecology, and Reproductive Sciences and Epidemiology, University of Pittsburgh School of Medicine, Pittsburgh, PA"},{"name":"Department of Magee, Women's Research Institute, Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Brooks","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siob\u00e1n D.","family":"Harlow","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen R.","family":"Isasi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Health Systems, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen A.","family":"Matthews","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA"},{"name":"Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca C.","family":"Thurston","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA"},{"name":"Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Barinas\u2010Mitchell","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","unstructured":"Centers for Disease Control and Prevention . 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