{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T08:10:49Z","timestamp":1791447049532,"version":"4.3.3"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,12,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Data are sparse regarding the value of physical activity (\n              <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>\n              ) surveillance among older adults\u2014particularly among those with mobility limitations. The objective of this study was to examine longitudinal associations between objectively measured daily\n              <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>\n              and the incidence of cardiovascular events among older adults in the\n              <jats:styled-content style=\"fixed-case\">LIFE<\/jats:styled-content>\n              (Lifestyle Interventions and Independence for Elders) study.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Cardiovascular events were adjudicated based on medical records review, and cardiovascular risk factors were controlled for in the analysis. Home\u2010based activity data were collected by hip\u2010worn accelerometers at baseline and at 6, 12, and 24\u00a0months postrandomization to either a physical activity or health education intervention.\n              <jats:styled-content style=\"fixed-case\">LIFE<\/jats:styled-content>\n              study participants (n=1590; age 78.9\u00b15.2 [\n              <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n              ] years; 67.2% women) at baseline had an 11% lower incidence of experiencing a subsequent cardiovascular event per 500\u00a0steps taken per day based on activity data (hazard ratio, 0.89; 95% confidence interval, 0.84\u20130.96;\n              <jats:italic>P<\/jats:italic>\n              =0.001). At baseline, every 30\u00a0minutes spent performing activities \u2265500\u00a0counts per minute (hazard ratio, 0.75; confidence interval, 0.65\u20130.89 [\n              <jats:italic>P<\/jats:italic>\n              =0.001]) were also associated with a lower incidence of cardiovascular events. Throughout follow\u2010up (6, 12, and 24\u00a0months), both the number of steps per day (per 500\u00a0steps; hazard ratio, 0.90, confidence interval, 0.85\u20130.96 [\n              <jats:italic>P<\/jats:italic>\n              =0.001]) and duration of activity \u2265500\u00a0counts per minute (per 30\u00a0minutes; hazard ratio, 0.76; confidence interval, 0.63\u20130.90 [\n              <jats:italic>P<\/jats:italic>\n              =0.002]) were significantly associated with lower cardiovascular event rates.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Objective measurements of physical activity via accelerometry were associated with cardiovascular events among older adults with limited mobility (summary score &gt;10 on the Short Physical Performance Battery) both using baseline and longitudinal data.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Clinical Trial Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              <jats:styled-content style=\"fixed-case\">URL<\/jats:styled-content>\n              :\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier:\n              <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>\n              01072500.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.117.007215","type":"journal-article","created":{"date-parts":[[2017,12,3]],"date-time":"2017-12-03T01:10:14Z","timestamp":1512263414000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":48,"title":["Association of Accelerometry\u2010Measured Physical Activity and Cardiovascular Events in Mobility\u2010Limited Older Adults: The LIFE (Lifestyle Interventions and Independence for Elders) Study"],"prefix":"10.1161","volume":"6","author":[{"given":"Shannon K.","family":"Cochrane","sequence":"first","affiliation":[{"name":"University of Florida College of Medicine, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyh\u2010Huei","family":"Chen","sequence":"additional","affiliation":[{"name":"Wake Forest 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