{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:31:04Z","timestamp":1792114264663,"version":"4.4.0"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,7,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              There is limited information about the long\u2010term survival of older patients after myocardial infarction (\n              <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>\n              ).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              <jats:styled-content style=\"fixed-case\">CRUSADE<\/jats:styled-content>\n              (Can rapid risk stratification of unstable angina patients suppress adverse outcomes with early implementation of the ACC\/AHA guidelines) was a registry of\n              <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>\n              patients treated at 568 US hospitals from 2001 to 2006. We linked\n              <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>\n              patients aged \u226565\u00a0years in\n              <jats:styled-content style=\"fixed-case\">CRUSADE<\/jats:styled-content>\n              to their Medicare data to ascertain long\u2010term mortality (defined as 8 years post index event). Long\u2010term unadjusted Kaplan\u2013Meier mortality curves were examined among patients stratified by revascularization status. A landmark analysis conditioned on surviving the first year post\u2010\n              <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>\n              was conducted. We used multivariable Cox regression to compare mortality risks between ST\u2010segment\u2013elevation myocardial infarction and non\u2013ST\u2010segment\u2013elevation myocardial infarction patients. Among 22\u00a0295\n              <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>\n              patients \u2265 age 65 years (median age 77\u00a0years), we observed high rates of evidence\u2010based medication use at discharge: aspirin 95%, \u03b2\u2010blockers 94%, and statins 81%. Despite this, mortality rates were high: 24% at 1\u00a0year, 51% at 5\u00a0years, and 65% at 8\u00a0years. Eight\u2010year mortality remained high among patients who underwent percutaneous coronary intervention (49%), coronary artery bypass graft (46%), and among patients who survived the first year post\u2010\n              <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>\n              (59%). Median survival was 4.8\u00a0years (25th, 75th percentiles 1.1, 8.5); among patients aged 65\u201374\u00a0years it was 8.2\u00a0years (3.3, 8.9) while for patients aged \u226575\u00a0years it was 3.1\u00a0years (0.6, 7.6). Eight\u2010year mortality was lower among ST\u2010segment\u2013elevation myocardial infarction than non\u2013ST\u2010segment\u2013elevation myocardial infarction patients (53% versus 67%); this difference was not significant after adjustment (hazard ratio 0.94, 95% confidence interval, 0.88\u20131.00).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Long\u2010term mortality remains high among patients with\n              <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>\n              in routine clinical practice, even among revascularized patients and those who survived the first year.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.117.007230","type":"journal-article","created":{"date-parts":[[2018,6,30]],"date-time":"2018-06-30T09:15:10Z","timestamp":1530350110000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":82,"title":["Long\u2010Term Mortality of Older Patients With Acute Myocardial Infarction Treated in US Clinical Practice"],"prefix":"10.1161","volume":"7","author":[{"given":"Ajar","family":"Kochar","sequence":"first","affiliation":[{"name":"Duke Clinical Research Institute Duke University School of Medicine Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita Y.","family":"Chen","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute Duke University School of Medicine Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puza P.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Novartis Pharmaceuticals Corporation East Hanover NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha J.","family":"Pagidipati","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute Duke University School of Medicine Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregg C.","family":"Fonarow","sequence":"additional","affiliation":[{"name":"Ronald Reagan UCLA Medical Center Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia A.","family":"Cowper","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute Duke University School of Medicine Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew T.","family":"Roe","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute Duke University School of Medicine Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric D.","family":"Peterson","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute Duke University School of Medicine Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy Y.","family":"Wang","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute Duke University School of Medicine Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.182615"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01166-6"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2014.01.013"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/2048872614565928"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1197\/aemj.9.11.1146"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2008.01.009"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2009.04.002"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2011.08.010"},{"key":"e_1_3_1_10_2","first-page":"1","article-title":"United States life tables, 2004","volume":"56","author":"Arias E","year":"2007","unstructured":"Arias E. 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