{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:59:07Z","timestamp":1790888347067,"version":"4.1.0"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,1,23]]},"abstract":"\n Background<\/jats:title>\n \n Myocardial infarction increases the risk of heart failure (\n HF<\/jats:styled-content>\n ) and atrial fibrillation. Renal denervation (\n RDN<\/jats:styled-content>\n ) might suppress the development of atrial remodeling. This study aimed to elucidate the molecular mechanism of\n RDN<\/jats:styled-content>\n in the suppression of atrial fibrillation in a\n HF<\/jats:styled-content>\n model after myocardial infarction.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n HF<\/jats:styled-content>\n rabbits were created 4\u00a0weeks after coronary ligation. Rabbits were classified into 3 groups: normal control (n=10),\n HF<\/jats:styled-content>\n (n=10), and\n HF<\/jats:styled-content>\n \u2010\n RDN<\/jats:styled-content>\n (n=6). Surgical and chemical\n RDN<\/jats:styled-content>\n were approached through midabdominal incisions in\n HF<\/jats:styled-content>\n \u2010\n RDN<\/jats:styled-content>\n . Left anterior descending coronary artery in\n HF<\/jats:styled-content>\n and\n HF<\/jats:styled-content>\n \u2010\n RDN<\/jats:styled-content>\n was ligated to create myocardial infarction. After electrophysiological study, the rabbits were euthanized and the left atrial appendage was harvested for real\u2010time polymerase chain reaction analysis and Trichrome stain. Left atrial dimension and left ventricular mass were smaller in\n HF<\/jats:styled-content>\n \u2010\n RDN<\/jats:styled-content>\n by echocardiography compared with\n HF<\/jats:styled-content>\n . Attenuated atrial fibrosis and tyrosine hydroxylase levels were observed in\n HF<\/jats:styled-content>\n \u2010\n RDN<\/jats:styled-content>\n compared with\n HF<\/jats:styled-content>\n . The\n mRNA<\/jats:styled-content>\n expressions of Cav1.2, Nav1.5, Kir2.1, Kv\n LQT<\/jats:styled-content>\n 1, phosphoinositide 3\u2010kinase,\n AKT<\/jats:styled-content>\n , and endothelial nitric oxide synthase in\n HF<\/jats:styled-content>\n \u2010\n RDN<\/jats:styled-content>\n were significantly higher compared with\n HF<\/jats:styled-content>\n . The effective refractory period and action potential duration of\n HF<\/jats:styled-content>\n \u2010\n RDN<\/jats:styled-content>\n were significantly shorter compared with\n HF<\/jats:styled-content>\n . Decreased atrial fibrillation inducibility was noted in\n HF<\/jats:styled-content>\n \u2010\n RDN<\/jats:styled-content>\n compared with\n HF<\/jats:styled-content>\n (50% versus 100%,\n P<\/jats:italic>\n <0.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n RDN<\/jats:styled-content>\n reversed atrial electrical and structural remodeling, and suppressed the atrial fibrillation inducibility in an ischemic\n HF<\/jats:styled-content>\n model. The beneficial effect of\n RDN<\/jats:styled-content>\n may be related to prevention of the downregulation of the phosphoinositide 3\u2010kinase\/\n AKT<\/jats:styled-content>\n \/endothelial nitric oxide synthase signaling pathway.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.117.007312","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T20:10:55Z","timestamp":1516651855000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":32,"title":["Impact of Renal Denervation on Atrial Arrhythmogenic Substrate in Ischemic Model of Heart Failure"],"prefix":"10.1161","volume":"7","author":[{"given":"Shinya","family":"Yamada","sequence":"first","affiliation":[{"name":"Taipei Veterans General Hospital","place":["Taipei, Taiwan"]},{"name":"Fukushima Medical University","place":["Fukushima, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man\u2010Cai","family":"Fong","sequence":"additional","affiliation":[{"name":"Cheng Hsin General Hospital","place":["Taipei, Taiwan"]},{"name":"National Defense Medical Center","place":["Taipei, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u2010Wen","family":"Hsiao","sequence":"additional","affiliation":[{"name":"Taipei Veterans General Hospital","place":["Taipei, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih\u2010Lin","family":"Chang","sequence":"additional","affiliation":[{"name":"Taipei Veterans General Hospital","place":["Taipei, Taiwan"]},{"name":"National Yang\u2010Ming University","place":["Taipei, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung\u2010Nan","family":"Tsai","sequence":"additional","affiliation":[{"name":"Taipei Veterans General Hospital","place":["Taipei, Taiwan"]},{"name":"National Yang\u2010Ming University","place":["Taipei, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Wei","family":"Lo","sequence":"additional","affiliation":[{"name":"Taipei Veterans General Hospital","place":["Taipei, Taiwan"]},{"name":"National Yang\u2010Ming University","place":["Taipei, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tze\u2010Fan","family":"Chao","sequence":"additional","affiliation":[{"name":"Taipei Veterans General Hospital","place":["Taipei, Taiwan"]},{"name":"National Yang\u2010Ming University","place":["Taipei, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yenn\u2010Jiang","family":"Lin","sequence":"additional","affiliation":[{"name":"Taipei Veterans General Hospital","place":["Taipei, Taiwan"]},{"name":"National Yang\u2010Ming University","place":["Taipei, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Feng","family":"Hu","sequence":"additional","affiliation":[{"name":"Taipei Veterans General Hospital","place":["Taipei, Taiwan"]},{"name":"National Yang\u2010Ming University","place":["Taipei, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fa\u2010Po","family":"Chung","sequence":"additional","affiliation":[{"name":"Taipei Veterans General Hospital","place":["Taipei, Taiwan"]},{"name":"National Yang\u2010Ming University","place":["Taipei, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u2010Nan","family":"Liao","sequence":"additional","affiliation":[{"name":"Taipei Veterans General Hospital","place":["Taipei, Taiwan"]},{"name":"National Yang\u2010Ming University","place":["Taipei, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao\u2010Ting","family":"Chang","sequence":"additional","affiliation":[{"name":"Taipei Veterans General Hospital","place":["Taipei, Taiwan"]},{"name":"National Yang\u2010Ming University","place":["Taipei, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsing\u2010Yuan","family":"Li","sequence":"additional","affiliation":[{"name":"Taipei Veterans General Hospital","place":["Taipei, Taiwan"]},{"name":"Taipei Veterans General Hospital","place":["Taipei, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Higa","sequence":"additional","affiliation":[{"name":"Makiminato Central Hospital","place":["Okinawa, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih\u2010Ann","family":"Chen","sequence":"additional","affiliation":[{"name":"Taipei Veterans General Hospital","place":["Taipei, Taiwan"]},{"name":"National Yang\u2010Ming University","place":["Taipei, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/S0025-6196(12)60078-0","article-title":"Congestive heart failure: insights from epidemiology, implications for treatment","volume":"68","author":"Yamani M","year":"1993","unstructured":"Yamani M, Massie BM. 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