{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:03:37Z","timestamp":1792191817715,"version":"4.4.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,12,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Lipoprotein(a) (Lp[a]) is proatherosclerotic and prothrombotic, causally related to coronary disease, and associated with other cardiovascular diseases. The association of Lp(a) with incident atrial fibrillation (\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              ) and with ischemic stroke among individuals with\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              remains to be elucidated.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In the community\u2010based\n              <jats:styled-content style=\"fixed-case\">ARIC<\/jats:styled-content>\n              (Atherosclerosis Risk in Communities) study cohort, Lp(a) levels were measured by a Denka Seiken assay at visit 4 (1996\u20131998). We used multivariable\u2010adjusted Cox models to compare\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              and ischemic stroke risk across Lp(a) levels. First, we evaluated incident\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              in 9908 participants free of\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              at baseline.\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              was ascertained by electrocardiography at study visits, hospital\n              <jats:italic>International Statistical Classification of Diseases, 9th Revision<\/jats:italic>\n              (\n              <jats:italic>ICD\u20109<\/jats:italic>\n              ) codes, and death certificates. We then evaluated incident ischemic stroke in 10\u00a0127 participants free of stroke at baseline. Stroke was identified by annual phone calls, hospital\n              <jats:italic>ICD\u20109 Revision<\/jats:italic>\n              codes, and death certificates. The baseline age was 62.7\u00b15.6\u00a0years. Median Lp(a) levels were 13.3 mg\/dL (interquartile range, 5.2\u201339.7 mg\/dL). Median follow\u2010up was 13.9 and 15.8\u00a0years for\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              and stroke, respectively. Lp(a) was not associated with incident\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              (hazard ratio, 0.98; 95% confidence interval, 0.82\u20131.17), comparing those with Lp(a) \u226550 with those with Lp(a) &lt;10\u00a0mg\/dL. High Lp(a) was associated with a 42% relative increase in stroke risk among participants without\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              (hazard ratio, 1.42; 95% confidence interval, 1.07\u20131.90) but not in those with\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              (hazard ratio, 1.06; 95% confidence interval, 0.70\u20131.61 [\n              <jats:italic>P<\/jats:italic>\n              interaction for\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              =0.25]). There were no interactions by race or sex. No association was found for cardioembolic stroke subtype.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              High Lp(a) levels were not associated with incident\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              . Lp(a) levels were associated with increased ischemic stroke risk, primarily among individuals without\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              but not in those with\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              .\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.117.007372","type":"journal-article","created":{"date-parts":[[2017,12,16]],"date-time":"2017-12-16T01:11:27Z","timestamp":1513386687000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":72,"title":["Associations of Lipoprotein(a) Levels With Incident Atrial Fibrillation and Ischemic Stroke: The ARIC (Atherosclerosis Risk in Communities) Study"],"prefix":"10.1161","volume":"6","author":[{"given":"Konstantinos N.","family":"Aronis","sequence":"first","affiliation":[{"name":"Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron C.","family":"Hoogeveen","sequence":"additional","affiliation":[{"name":"Division of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Alonso","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christie M.","family":"Ballantyne","sequence":"additional","affiliation":[{"name":"Division of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliseo","family":"Guallar","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Jones","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth S.","family":"Martin","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD"},{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saman","family":"Nazarian","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of Pennsylvania Medical System University of Pennsylvania School of Medicine, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian T.","family":"Steffen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salim S.","family":"Virani","sequence":"additional","affiliation":[{"name":"Michael E. DeBakey Veterans Affairs Medical Center and Section\u00a0of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin D.","family":"Michos","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD"},{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)90885-9"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/330132a0"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.10.2980"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.10.1082"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1063"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.106.480657"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.08.021"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.045120"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.19.2486"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.801"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.09.038"},{"key":"e_1_3_4_13_2","first-page":"CR122","article-title":"Lipoprotein(a) and lipid profile in patients with atrial fibrillation","volume":"12","author":"Diaz\u2010Peromingo JA","year":"2006","unstructured":"Diaz\u2010Peromingo JA, Alban\u2010Salgado A, Garcia\u2010Suarez F, Sanchez\u2010Leira J, Saborido\u2010Frojan J, Iglesias\u2010Gallego M. 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