{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T22:03:51Z","timestamp":1772402631581,"version":"3.50.1"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,1,23]]},"abstract":"\n Background<\/jats:title>\n \n Aortic dissection (\n AD<\/jats:styled-content>\n ) is a life\u2010threatening medical emergency caused by the abrupt destruction of the intimomedial layer of the aortic walls. Given that previous studies have reported the involvement of proinflammatory cytokine interleukin\u20106 in\n AD<\/jats:styled-content>\n pathogenesis, we investigated the role of signal transduction and activator of transcription 3 signaling, a downstream pathway of interleukin\u20106 in macrophages in pathogenesis of\n AD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We characterized the pathological and molecular events triggered by aortic stress, which can lead to\n AD<\/jats:styled-content>\n . Aortic stress on the suprarenal aorta because of infrarenal aorta stiffening and angiotensin\n II<\/jats:styled-content>\n infusion for 1\u00a0week caused focal medial rupture at the branching point of the celiac trunk and superior mesenteric artery. This focal medial rupture healed in 6\u00a0weeks in wild\u2010type (\n WT<\/jats:styled-content>\n ) mice, but progressed to\n AD<\/jats:styled-content>\n in mice with macrophage\u2010specific deletion of\n Socs3<\/jats:italic>\n gene (\n mS<\/jats:styled-content>\n ocs3\u2010\n KO<\/jats:styled-content>\n ).\n mS<\/jats:styled-content>\n ocs3\u2010\n KO<\/jats:styled-content>\n mice showed premature activation of cell proliferation, an inflammatory response, and skewed differentiation of macrophages toward the tissue\u2010destructive phenotype. Concomitantly, they showed aberrant phenotypic modulation of smooth muscle cells and transforming growth factor beta signaling, which are likely to participate in tissue repair. Human\n AD<\/jats:styled-content>\n samples revealed signal transduction and activator of transcription 3 activation in adventitial macrophages adjacent to the site of tissue destruction.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n These findings suggest that\n AD<\/jats:styled-content>\n development is preceded by focal medial rupture, in which macrophage Socs3 maintains proper inflammatory response and differentiation of\n SMC<\/jats:styled-content>\n s, thus promoting fibrotic healing to prevent tissue destruction and\n AD<\/jats:styled-content>\n development. Understanding the sequence of the pathological and molecular events preceding\n AD<\/jats:styled-content>\n development will help predict and prevent\n AD<\/jats:styled-content>\n development and progression.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.117.007389","type":"journal-article","created":{"date-parts":[[2018,1,17]],"date-time":"2018-01-17T20:10:32Z","timestamp":1516219832000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":33,"title":["Role of Macrophage Socs3 in the Pathogenesis of Aortic Dissection"],"prefix":"10.1161","volume":"7","author":[{"given":"Satoko","family":"Ohno\u2010Urabe","sequence":"first","affiliation":[{"name":"Kurume University School of Medicine","place":["Kurume, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Aoki","sequence":"additional","affiliation":[{"name":"Kurume University","place":["Kurume, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michihide","family":"Nishihara","sequence":"additional","affiliation":[{"name":"Kurume University School of Medicine","place":["Kurume, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aya","family":"Furusho","sequence":"additional","affiliation":[{"name":"Kurume University School of Medicine","place":["Kurume, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saki","family":"Hirakata","sequence":"additional","affiliation":[{"name":"Kurume University School of Medicine","place":["Kurume, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norifumi","family":"Nishida","sequence":"additional","affiliation":[{"name":"Kurume University School of Medicine","place":["Kurume, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sohei","family":"Ito","sequence":"additional","affiliation":[{"name":"Kurume University School of Medicine","place":["Kurume, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makiko","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Kurume University School of Medicine","place":["Kurume, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Yasukawa","sequence":"additional","affiliation":[{"name":"Kurume University School of Medicine","place":["Kurume, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Imaizumi","sequence":"additional","affiliation":[{"name":"International University of Health and Welfare","place":["Fukuoka, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetoshi","family":"Akashi","sequence":"additional","affiliation":[{"name":"Kurume University School of Medicine","place":["Kurume, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Kurume University School of Medicine","place":["Kurume, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Fukumoto","sequence":"additional","affiliation":[{"name":"Kurume University School of Medicine","place":["Kurume, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","volume-title":"Vascular Surgery","author":"Cronenwett JL","year":"2014","unstructured":"Cronenwett JL, Johnston KW. 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