{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:38:54Z","timestamp":1793299134653,"version":"4.5.0"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,2,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Exposure to preeclampsia or gestational hypertension is associated with higher offspring systolic blood pressure (\n              <jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content>\n              ), but less is known about associations with other cardiometabolic risk markers.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We studied 1097 children from the Project Viva cohort born 1999\u20102002. Exposures were preeclampsia or gestational hypertension and mean maternal\n              <jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content>\n              in each trimester from prenatal records. Outcomes were research measures in midchildhood (mean 8.0\u00a0years) of\n              <jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content>\n              , overall adiposity, and a global cardiometabolic risk score comprising measures of\n              <jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content>\n              , waist circumference, glycemia, and lipids. We conducted linear regression analyses adjusted for maternal characteristics and offspring sex and age. In adjusted models, maternal preeclampsia or gestational hypertension (n=98, 9.1%) versus normal blood pressure was associated with slightly higher offspring\n              <jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content>\n              z\u2010score (0.15\u00a0units; 95% confidence interval [CI] \u22120.03, 0.32) but otherwise predicted better cardiometabolic health markers including metabolic risk z\u2010score (\u22120.23\u00a0units; \u221295%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              0.44, \u22120.03) and several of its components as well as lower body mass index z\u2010score (\u22120.27\u00a0units; 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              \u22120.48, \u22120.06) and lower fat mass index (\u22120.91\u00a0kg\/m\n              <jats:sup>2<\/jats:sup>\n              ; 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              \u22121.35, \u22120.47). Similarly, higher mean third\u2010trimester maternal\n              <jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content>\n              was associated with higher offspring\n              <jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content>\n              z\u2010score (0.09\u00a0units per 10\u00a0mm\u00a0Hg; 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              0.02, 0.16) and lower overall and central adiposity but not with biomarkers of metabolic risk. Results for second\u2010trimester\n              <jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content>\n              were generally similar. First\u2010trimester blood pressure was associated with higher offspring blood pressure but not with other outcomes.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Higher maternal late\u2010pregnancy\n              <jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content>\n              and hypertensive disorders of pregnancy were associated with higher offspring\n              <jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content>\n              but otherwise better cardiometabolic health.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.117.007426","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T01:10:21Z","timestamp":1517361021000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":34,"title":["Hypertensive Disorders of Pregnancy and Offspring Cardiometabolic Health at Midchildhood: Project Viva Findings"],"prefix":"10.1161","volume":"7","author":[{"given":"Ruby Reetika","family":"Tripathi","sequence":"first","affiliation":[{"name":"Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA"},{"name":"Department of Chronic Disease Epidemiology, Yale University, New Haven, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheryl L.","family":"Rifas\u2010Shiman","sequence":"additional","affiliation":[{"name":"Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Hawley","sequence":"additional","affiliation":[{"name":"Department of Chronic Disease Epidemiology, Yale University, New Haven, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010France","family":"Hivert","sequence":"additional","affiliation":[{"name":"Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA"},{"name":"Diabetes Unit, Massachusetts General Hospital, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Oken","sequence":"additional","affiliation":[{"name":"Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA"},{"name":"Department of Nutrition, Harvard T.H. 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