{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T18:57:02Z","timestamp":1769108222508,"version":"3.49.0"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,12,2]]},"abstract":"\n Background<\/jats:title>\n \n Subclinical atrial fibrillation is one possible cause of embolic stroke of undetermined source (\n ESUS<\/jats:styled-content>\n ). It remains to be elucidated if a specific infarction site has a predictive value for detecting subclinical atrial fibrillation. We aimed to investigate the predictive value of infarction site in patients with ESUS for the detection of atrial tachyarrhythmia (\n AT<\/jats:styled-content>\n ) using an insertable cardiac monitor.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Consecutive 146 patients (84 men; aged 62\u00b112\u00a0years) underwent insertable cardiac monitor implantation after diagnosis of\n ESUS<\/jats:styled-content>\n . The detection of\n AT<\/jats:styled-content>\n >30\u00a0seconds was evaluated. The ESUS infarction sites were categorized into internal carotid artery and vertebral artery (\n VA<\/jats:styled-content>\n ) territories, with ophthalmic artery, anterior cerebral artery, and middle cerebral artery as internal carotid artery subterritories, and posterior cerebral artery and other vertebrobasilar arteries as\n VA<\/jats:styled-content>\n subterritories. During a median follow\u2010up of 387\u00a0days,\n AT<\/jats:styled-content>\n was detected in 33 patients (23%). Subclinical\n AT<\/jats:styled-content>\n detection was significantly more frequent after\n VA<\/jats:styled-content>\n territorial infarction opposed to internal carotid artery infarction (20\/57 [35%] versus 13\/89 [15%];\n P<\/jats:italic>\n =0.0039). Kaplan\u2010Meier analysis demonstrated a significantly higher\n AT<\/jats:styled-content>\n detection rate after\n VA<\/jats:styled-content>\n infarction (log\u2010rank,\n P<\/jats:italic>\n =0.0076). Regression analysis revealed that\n VA<\/jats:styled-content>\n territorial infarction, and particularly posterior cerebral artery area infarction, was an independent predictor of\n AT<\/jats:styled-content>\n detection.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Patients with\n ESUS<\/jats:styled-content>\n in the posterior cerebral artery territory had a higher rate of subclinical\n AT<\/jats:styled-content>\n detection than those with other infarct localizations. Our data suggest that the possible usefulness of\n ESUS<\/jats:styled-content>\n site to identify candidates for direct oral anticoagulation should be confirmed in future research.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.117.007448","type":"journal-article","created":{"date-parts":[[2017,11,30]],"date-time":"2017-11-30T01:10:10Z","timestamp":1512004210000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["High Incidence of Atrial Fibrillation After Embolic Stroke of Undetermined Source in Posterior Cerebral Artery Territory"],"prefix":"10.1161","volume":"6","author":[{"given":"Hisaki","family":"Makimoto","sequence":"first","affiliation":[{"name":"Cardiac Arrhythmia Service, Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University D\u00fcsseldorf, D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammed","family":"Kurt","sequence":"additional","affiliation":[{"name":"Cardiac Arrhythmia Service, Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University D\u00fcsseldorf, D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Gliem","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical Faculty, University D\u00fcsseldorf, D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John\u2010Ih","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical Faculty, University D\u00fcsseldorf, D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Cardiac Arrhythmia Service, Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University D\u00fcsseldorf, D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Cardiac Arrhythmia Service, Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University D\u00fcsseldorf, D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Clasen","sequence":"additional","affiliation":[{"name":"Cardiac Arrhythmia Service, Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University D\u00fcsseldorf, D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Brinkmeyer","sequence":"additional","affiliation":[{"name":"Cardiac Arrhythmia Service, Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University D\u00fcsseldorf, D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong\u2010In","family":"Shin","sequence":"additional","affiliation":[{"name":"Cardiac Arrhythmia Service, Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University D\u00fcsseldorf, D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Jander","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical Faculty, University D\u00fcsseldorf, D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malte","family":"Kelm","sequence":"additional","affiliation":[{"name":"Cardiac Arrhythmia Service, Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University D\u00fcsseldorf, D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"F\u00fcrnkranz","sequence":"additional","affiliation":[{"name":"Cardiac Arrhythmia Service, Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University D\u00fcsseldorf, D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70310-7"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000024"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2015.1057612"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.09.058"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2302"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.009334"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000092331"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12630"},{"key":"e_1_3_2_10_2","article-title":"Apixaban for treatment of embolic stroke of undetermined source (ATTICUS randomized trial): rationale and study design","author":"Geisler T","year":"2016","unstructured":"Geisler T, Poli S, Meisner C, Schreieck J, Zuern CS, N\u00e4gele T, Brachmann J, Jung W, Gahn G, Schmid E, B\u00e4ezner H, Keller T, Petzold GC, Schrickel JW, Liman J, Wachter R, Sch\u00f6n F, Schabet M, Lindner A, Ludolph AC, Kimmig H, Jander S, Schlegel U, Gawaz M, Ziemann U. Apixaban for treatment of embolic stroke of undetermined source (ATTICUS randomized trial): rationale and study design. Int J Stroke. 2016. pii: 1747493016681019. [Epub ahead of print]","journal-title":"Int J Stroke"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.007453"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.002459"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.016467"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31828f1828"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1313600"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.117.007448","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:44:10Z","timestamp":1715600650000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.117.007448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,2]]},"references-count":14,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12,2]]}},"alternative-id":["10.1161\/JAHA.117.007448"],"URL":"https:\/\/doi.org\/10.1161\/jaha.117.007448","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,2]]},"assertion":[{"value":"2017-08-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-10-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-11-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e007448"}}