{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T14:57:04Z","timestamp":1792508224858,"version":"4.5.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,12,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              New\u2010onset atrial fibrillation (\n              <jats:styled-content style=\"fixed-case\">NOAF<\/jats:styled-content>\n              ) after coronary artery bypass graft is related to an increased short\u2010term risk of stroke and mortality. We investigated whether the long\u2010term risk of stroke is increased.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We performed a systematic review and meta\u2010analysis of studies that included patients who had coronary artery bypass graft and who afterwards developed\n              <jats:styled-content style=\"fixed-case\">NOAF<\/jats:styled-content>\n              during their index admission; these patients did not have previous atrial fibrillation. The primary outcome was risk of stroke at 6\u00a0months or more in patients who developed\n              <jats:styled-content style=\"fixed-case\">NOAF<\/jats:styled-content>\n              compared with those who did not. Odds ratios, relative risk, and hazard ratios were considered equivalent; outcomes were pooled on the log\u2010ratio scale using a random\u2010effects model and reported as exponentiated effect\u2010sizes. We included 16 studies, comprising 108\u00a0711 participants with a median follow\u2010up period of 2.05\u00a0years. Average participant age was 66.8\u00a0years, with studies including an average of 74.8% males. There was an increased long\u2010term risk of stroke in the presence of\n              <jats:styled-content style=\"fixed-case\">NOAF<\/jats:styled-content>\n              (unadjusted studies effect\u2010sizes=1.36, 95% confidence interval, 1.12\u20131.65,\n              <jats:italic>P<\/jats:italic>\n              =0.001, adjusted studies effect\u2010sizes=1.25, 95% confidence interval, 1.09\u20131.42,\n              <jats:italic>P<\/jats:italic>\n              =0.001). There was evidence of moderate effect variation because of heterogeneity in studies reporting unadjusted (\n              <jats:italic>P<\/jats:italic>\n              =0.021, I\n              <jats:sup>2<\/jats:sup>\n              =49.8%) and adjusted data (\n              <jats:italic>P<\/jats:italic>\n              =0.081, I\n              <jats:sup>2<\/jats:sup>\n              =49.1%), and publication bias in the latter group (Egger's test,\n              <jats:italic>P<\/jats:italic>\n              =0.031). Sensitivity analysis on unadjusted data by study quality, design, and surgery did not alter the effect direction.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Presence of\n              <jats:styled-content style=\"fixed-case\">NOAF<\/jats:styled-content>\n              in patients post\u2013coronary artery bypass graft is associated with increased long\u2010term risk of stroke compared with patients without\n              <jats:styled-content style=\"fixed-case\">NOAF<\/jats:styled-content>\n              . Further studies may show whether the increased risk is mediated by atrial fibrillation and whether anticoagulation reduces risk.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.117.007558","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T01:11:19Z","timestamp":1513991479000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":49,"title":["New\u2010Onset Atrial Fibrillation After Coronary Artery Bypass Graft and Long\u2010Term Risk of Stroke: A Meta\u2010Analysis"],"prefix":"10.1161","volume":"6","author":[{"given":"Matthew R.","family":"Megens","sequence":"first","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia"},{"name":"School of Sciences, RMIT University, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonid","family":"Churilov","sequence":"additional","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia"},{"name":"School of Sciences, RMIT University, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Thijs","sequence":"additional","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia"},{"name":"Department of Neurology, Austin Health, Heidelberg, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199710000-00011"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.11.023"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2009.12.033"},{"issue":"1","key":"e_1_3_4_5_2","first-page":"II207","article-title":"Incidence and clinical consequences of atrial fibrillation within 1\u00a0year of first\u2010time isolated coronary bypass surgery","volume":"108","author":"Elahi M","year":"2003","unstructured":"Elahi M, Hadjinikolaou L, Galinanes M. 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