{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:34:48Z","timestamp":1790710488821,"version":"4.1.0"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,6,5]]},"abstract":"\n Background<\/jats:title>\n Little is known about the association of atrial fibrillation symptom burden with quality of life and outcomes.<\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n In the Prevention of Thromboembolic Events\u2013European Registry in Atrial Fibrillation (n=6196 patients with atrial fibrillation; mean\u00b1SD age, 71.8\u00b110.4\u00a0years; 39.7% women), we assessed European Heart Rhythm Association score symptoms and calculated correlations with the standardized health status questionnaire (\n EQ<\/jats:styled-content>\n \u20105D\u20105L). Patients were followed up for atrial fibrillation therapies and outcomes (stroke\/transient ischemic attack\/arterial thromboembolism, coronary events, heart failure, and major bleeding) over 1\u00a0year. Most individuals (92%) experienced symptoms. Correlations with health status and quality of life were modest. In multivariable\u2010adjusted regression models, the dichotomized European Heart Rhythm Association score (intermediate\/frequent versus never\/occasional symptoms) was associated with cardioversions (odds ratio [\n OR<\/jats:styled-content>\n ], 1.21; 95% confidence interval [\n CI<\/jats:styled-content>\n ], 1.01\u20131.45) and catheter ablation (\n OR,<\/jats:styled-content>\n 1.97; 95%\n CI,<\/jats:styled-content>\n 1.44\u20132.69), and inversely related with heart rate control (\n OR,<\/jats:styled-content>\n 0.80; 95%\n CI,<\/jats:styled-content>\n 0.70\u20130.92) and heart failure incidence (\n OR,<\/jats:styled-content>\n 1.65; 95%\n CI,<\/jats:styled-content>\n 1.16\u20132.34). Anxiety was inversely related with stroke\/transient ischemic attack\/arterial thromboembolism (\n OR,<\/jats:styled-content>\n 0.55; 95%\n CI,<\/jats:styled-content>\n 0.32\u20130.93), whereas chest pain related positively with coronary events (\n OR,<\/jats:styled-content>\n 2.45; 95%\n CI,<\/jats:styled-content>\n 1.42\u20134.22). Fatigue (\n OR,<\/jats:styled-content>\n 1.84; 95%\n CI,<\/jats:styled-content>\n 1.30\u20132.60), dyspnea (\n OR,<\/jats:styled-content>\n 2.33; 95%\n CI,<\/jats:styled-content>\n 1.63\u20133.33), and anxiety (\n OR,<\/jats:styled-content>\n 1.72; 95%\n CI,<\/jats:styled-content>\n 1.16\u20132.55) were associated with heart failure incidence. Palpitations were positively associated with cardioversion (\n OR,<\/jats:styled-content>\n 1.32; 95%\n CI,<\/jats:styled-content>\n 1.08\u20131.61) and ablation therapy (\n OR,<\/jats:styled-content>\n 2.02; 95%\n CI,<\/jats:styled-content>\n 1.48\u20132.76).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n A higher symptom burden, in particular palpitations, predicted interventions to restore sinus rhythm. The score itself had limited predictive value, but its individual components were related to different and specific clinical events, and may thus be helpful to target patient management.<\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.117.007559","type":"journal-article","created":{"date-parts":[[2018,5,18]],"date-time":"2018-05-18T09:15:18Z","timestamp":1526634918000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":43,"title":["Symptom Burden of Atrial Fibrillation and Its Relation to Interventions and Outcome in Europe"],"prefix":"10.1161","volume":"7","author":[{"given":"Renate B.","family":"Schnabel","sequence":"first","affiliation":[{"name":"University Heart Center Hamburg Eppendorf, Hamburg, Germany"},{"name":"German Center for Cardiovascular Research partner site, Hamburg\/Kiel\/L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ladislav","family":"Pecen","sequence":"additional","affiliation":[{"name":"Medical Faculty Pilsen of Charles University, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nargiz","family":"Rzayeva","sequence":"additional","affiliation":[{"name":"University Heart Center Hamburg Eppendorf, Hamburg, Germany"},{"name":"German Center for Cardiovascular Research partner site, Hamburg\/Kiel\/L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Lucerna","sequence":"additional","affiliation":[{"name":"Daiichi Sankyo Europe, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanish","family":"Purmah","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences, University of Birmingham, United Kingdom"},{"name":"Sandwell and West Birmingham Hospitals (SWBH) and University Hospitals Birmingham (UHB) NHS Trust, Birmingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco M.","family":"Ojeda","sequence":"additional","affiliation":[{"name":"University Heart Center Hamburg Eppendorf, Hamburg, Germany"},{"name":"German Center for Cardiovascular Research partner site, Hamburg\/Kiel\/L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"De Caterina","sequence":"additional","affiliation":[{"name":"G. d'Annunzio University, Chieti, Italy"},{"name":"Fondazione G. Monasterio, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulus","family":"Kirchhof","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences, University of Birmingham, United Kingdom"},{"name":"Sandwell and West Birmingham Hospitals (SWBH) and University Hospitals Birmingham (UHB) NHS Trust, Birmingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.005119"},{"key":"e_1_3_6_3_2","doi-asserted-by":"crossref","first-page":"B3","DOI":"10.1016\/j.hrthm.2004.03.070","article-title":"Overview of endpoints in atrial fibrillation studies","volume":"1","author":"Wyse DG","year":"2004","unstructured":"Wyse DG. Overview of endpoints in atrial fibrillation studies. Heart Rhythm. 2004;1(suppl):B3\u2013B7, discussion B7.","journal-title":"Heart Rhythm"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eum191"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eut395"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2014.11.026"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.114.001303"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eut263"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-012-0322-4"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-7-30"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.3109\/07853890109002087"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euw295"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw285"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.5603\/KP.a2015.0160"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2008.068908"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2006.08.011"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.06.032"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1105575"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.03.016"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euu151"},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2016.05.041"},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv390"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.117.007559","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:58:07Z","timestamp":1715597887000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.117.007559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,5]]},"references-count":21,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,6,5]]}},"alternative-id":["10.1161\/JAHA.117.007559"],"URL":"https:\/\/doi.org\/10.1161\/jaha.117.007559","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,5]]},"assertion":[{"value":"2018-01-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e007559"}}