{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T23:38:57Z","timestamp":1778283537326,"version":"3.51.4"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,1,23]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Cardiovascular disease in women often develops without conventional risk factors. Prenatal loss is a common pregnancy outcome that may result in physiological changes can increase the potential future risk of cardiovascular disease. Insufficient information exists regarding the impact of pregnancy loss on early markers of cardiovascular disease risk.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">Cross\u2010sectional analysis of 1767 disease\u2010free women from the MTC (Mexican Teachers' Cohort) who had been pregnant was used to evaluate the relationship between pregnancy loss and carotid intima\u2013media thickness (IMT). Participants responded to a questionnaire regarding their reproductive history, risk factors, and medical conditions. We defined pregnancy loss as history of miscarriage and\/or stillbirth. Trained neurologists measured IMT using ultrasound. We log\u2010transformed IMT and defined subclinical carotid atherosclerosis (SCA) as IMT \u22650.8\u00a0mm and\/or plaque. We used multivariable linear and logistic regression models to assess the relation of pregnancy loss, IMT, and SCA. The mean age of participants was 49.8\u00b15.1 years. The prevalence of pregnancy loss was 22%, and we observed SCA in 23% of participants. Comparing participants who reported a pregnancy loss and those who did not, the multivariable\u2010adjusted odds ratio for SCA was 1.52 (95% confidence interval, 1.12\u20132.06). Women who experienced a stillbirth had 2.32 higher odds (95% confidence interval, 1.03\u20135.21) of SCA than those who did not. Mean IMT appeared to be higher in women who reported a pregnancy loss relative to those who did not; nevertheless, this was not statistically significant.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Pregnancy loss could be linked to cardiovascular disease later in life. The key findings of our study await confirmation and further investigation of the potential underlying mechanisms for this association is required.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.117.007582","type":"journal-article","created":{"date-parts":[[2018,1,13]],"date-time":"2018-01-13T20:10:24Z","timestamp":1515874224000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Pregnancy Loss and Carotid Intima\u2013Media Thickness in Mexican Women"],"prefix":"10.1161","volume":"7","author":[{"given":"Sandra A.","family":"Hartasanchez","sequence":"first","affiliation":[{"name":"National Autonomous University of Mexico","place":["Mexico City, Mexico"]},{"name":"National Institute of Public Health","place":["Mexico City, Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Flores\u2010Torres","sequence":"additional","affiliation":[{"name":"National Institute of Public Health","place":["Mexico City, Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Monge","sequence":"additional","affiliation":[{"name":"National Institute of Public Health","place":["Mexico City, Mexico"]},{"name":"Instituto Tecnol\u00f3gico de Estudios Superiores de Monterrey","place":["Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsa","family":"Yunes","sequence":"additional","affiliation":[{"name":"National Institute of Public Health","place":["Mexico City, Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Instituto Tecnol\u00f3gico de Estudios Superiores de Monterrey","place":["Mexico"]},{"name":"University of Hawaii","place":["Honolulu"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Cantu\u2010Brito","sequence":"additional","affiliation":[{"name":"Instituto Tecnol\u00f3gico de Estudios Superiores de Monterrey","place":["Mexico"]},{"name":"National Institute of Medical Sciences and Nutrition Salvador Zubiran","place":["M\u00e9xico City, Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Colaci","sequence":"additional","affiliation":[{"name":"Institute for Clinical Effectiveness and Health Policy","place":["Buenos Aires, Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hector","family":"Lamadrid\u2010Figueroa","sequence":"additional","affiliation":[{"name":"National Institute of Public Health","place":["Mexico City, Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruy","family":"Lopez\u2010Ridaura","sequence":"additional","affiliation":[{"name":"National Institute of Public Health","place":["Mexico City, Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Lajous","sequence":"additional","affiliation":[{"name":"National Institute of Public Health","place":["Mexico City, Mexico"]},{"name":"Harvard T.H. 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