{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:36:41Z","timestamp":1792154201923,"version":"4.4.0"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,5,15]]},"abstract":"\n Background<\/jats:title>\n \n Atrial fibrillation\/flutter (\n AF<\/jats:styled-content>\n ) produces significant morbidity in women and is typically attributed to cardiac remodeling from multiple causes, particularly hypertension. Hypertensive pregnancy disorders (\n HPD<\/jats:styled-content>\n s) are associated with future hypertension and adverse cardiac remodeling. We evaluated whether women with\n AF<\/jats:styled-content>\n were more likely to have experienced a\n HPD<\/jats:styled-content>\n compared with those without.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n A nested case\u2013control study was conducted within a cohort of 7566 women who had a live or stillbirth delivery in Olmsted County, Minnesota between 1976 and 1982.\n AF<\/jats:styled-content>\n cases were matched (1:1) to controls based on date of birth, age at first pregnancy, and parity.\n AF<\/jats:styled-content>\n and pregnancy history were confirmed by chart review. We identified 105\n AF<\/jats:styled-content>\n cases: mean age 57\u00b18 (mean\u00b1\n SD<\/jats:styled-content>\n ) years, (controls 56\u00b18\u00a0years), 32\u00b18\u00a0years (controls 31\u00b18\u00a0years) after the first pregnancy. Cases were more likely to have obesity during childbearing years, and hypertension, diabetes mellitus, dyslipidemia, coronary disease, valvular disease, and heart failure at the time of\n AF<\/jats:styled-content>\n diagnosis. Cases were more likely to have a history of\n HPD<\/jats:styled-content>\n s, compared with controls: 28\/105 (26.7%) cases versus 12\/105 (11.4%) controls, odds ratio: 2.60 (95% confidence interval, 1.21\u20136.04). After adjustment for hypertension and obesity, the association was attenuated and no longer statistically significant; odds ratio (95% confidence interval, 2.12 (0.92\u20135.23).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Women with\n AF<\/jats:styled-content>\n are more likely to have had a\n HPD<\/jats:styled-content>\n , a relationship at least partially mediated by associated obesity and hypertension. Given the high morbidity of\n AF<\/jats:styled-content>\n , studies evaluating the benefit of screening for and management of cardiovascular risk factors in women with a history of\n HPD<\/jats:styled-content>\n should be performed.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.117.007584","type":"journal-article","created":{"date-parts":[[2018,5,13]],"date-time":"2018-05-13T09:20:10Z","timestamp":1526203210000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":32,"title":["Impact of a History of Hypertension in Pregnancy on Later Diagnosis of Atrial Fibrillation"],"prefix":"10.1161","volume":"7","author":[{"given":"Dawn C.","family":"Scantlebury","sequence":"first","affiliation":[{"name":"Faculty of Medical Sciences, University of the West Indies, St. Michael, Barbados"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea G.","family":"Kattah","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracey L.","family":"Weissgerber","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanket","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle M.","family":"Mielke","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN"},{"name":"Department of Neurology Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy L.","family":"Weaver","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa E.","family":"Vaughan","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislav","family":"Henkin","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Dartmouth\u2010Hitchcock Medical Center, Lebanon, NH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"Mayo Medical School, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia M.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Surgery, Mayo Clinic, Rochester, MN"},{"name":"Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy M.","family":"White","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharonne N.","family":"Hayes","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vesna D.","family":"Garovic","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN"},{"name":"Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.005119"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61774-8"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.553438"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39335.385301.BE"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.128751"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328335c29a"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000437382.03963.88"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2008.20"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.107928"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.162321"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-015-0628-8"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(00)24854-0"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2015-308098"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2010.02780.x"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02373-2"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq482"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2016.07.034"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.03.061"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.02.096"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60460-8"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328345500c"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2011-301548"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2015.12.040"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.06.023"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.150078"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.117.007584","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:15:41Z","timestamp":1715598941000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.117.007584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,15]]},"references-count":25,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,5,15]]}},"alternative-id":["10.1161\/JAHA.117.007584"],"URL":"https:\/\/doi.org\/10.1161\/jaha.117.007584","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,15]]},"assertion":[{"value":"2017-12-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e007584"}}