{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:08:40Z","timestamp":1788480520572,"version":"build-2803163510"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,12,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Pericardial effusions can be caused by a variety of disorders. The frequency of the underlying diseases varies with patient population; therefore, previously reported series are not necessarily representative of other populations. Our purpose was to examine the etiology of pericardial effusions and the survival of patients requiring pericardiocentesis at a tertiary center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We performed a retrospective observational study of 269 consecutive patients who underwent percutaneous pericardiocentesis at our university hospital between 2006 and 2016 and had prospective follow\u2010up for up to 10\u00a0years. The most frequent etiologies were idiopathic (26%), malignancy (25%), and iatrogenicity (20%), whereas bacterial causes were very rare. The most frequent malignancies originated from the lung (53%) or breast (18%). A new cancer was diagnosed with malignant pericardial effusion as the presenting complaint for 9% of patients, whereas the pericardium was the first metastatic site of a known malignancy in 4% of patients. Survival was significantly poorer in malignancy\u2010related versus non\u2013malignancy\u2010related effusions (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001) and in cytology\u2010positive versus cytology\u2010negative effusions in the overall cohort (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001). Among cancer\u2010only patients, however, there was no significant difference in long\u2010term survival between cytology\u2010positive and \u2010negative effusions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">In this contemporary tertiary\u2010center cohort, pericardial effusions often represent the primary instance of a new malignancy, underscoring the importance of cytological analyses of noniatrogenic effusions in patients without known cancer, as survival is significantly worse. In cancer patients, however, the presence of pericardial malignant cytology does not appear to affect outcome significantly.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.117.007598","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T20:10:33Z","timestamp":1514059833000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":57,"title":["Etiology and Long\u2010Term Outcome of Patients Undergoing Pericardiocentesis"],"prefix":"10.1161","volume":"6","author":[{"given":"Alexander","family":"Strobbe","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, University Hospitals Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Adriaenssens","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, University Hospitals Leuven, Belgium"},{"name":"Department of Cardiovascular Sciences, University of Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Bennett","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, University Hospitals Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Dubois","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, University Hospitals Leuven, Belgium"},{"name":"Department of Cardiovascular Sciences, University of Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Desmet","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, University Hospitals Leuven, Belgium"},{"name":"Department of Cardiovascular Sciences, University of Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keir","family":"McCutcheon","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, University Hospitals Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Van Cleemput","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, University Hospitals Leuven, Belgium"},{"name":"Department of Cardiovascular Sciences, University of Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R","family":"Sinnaeve","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, University Hospitals Leuven, Belgium"},{"name":"Department of Cardiovascular Sciences, University of Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2010.04.031"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.11.141"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2005.03.037"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.01.094"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.05.022"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.04.265"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.09.051"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.02.052"},{"key":"e_1_3_3_10_2","first-page":"234","article-title":"Pericardiocentesis in contemporary practice","volume":"23","author":"Inglis R","year":"2011","unstructured":"Inglis R, King AJ, Gleave M, Bradlow W, Adlam D. 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