{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:57:21Z","timestamp":1790200641841,"version":"4.1.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,1,23]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Many previous clinical studies have demonstrated that the nigrostriatal pathway, which plays a vital role in movement adjustment, is significantly impaired after stroke, according to medical imaging and autopsies. However, the basic pathomorphological changes have been poorly investigated to date. This study was designed to explore the pathomorphological changes, mechanism, and therapeutic method of nigrostriatal impairment after intracerebral hemorrhage (\n              <jats:styled-content style=\"fixed-case\" toggle=\"no\">ICH<\/jats:styled-content>\n              ).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Intrastriatal injection of autologous blood or microtubule depolymerization reagent nocodazole was performed to mimic the pathology of\n              <jats:styled-content style=\"fixed-case\" toggle=\"no\">ICH<\/jats:styled-content>\n              in C57\/\n              <jats:styled-content style=\"fixed-case\" toggle=\"no\">BL<\/jats:styled-content>\n              6 mice. Immunofluorescence, Western blotting, electron microscopy, functional behavioral tests, and anterograde and retrograde neural circuit tracking techniques were used in these mice. The data showed that the number of dopamine neurons and the dopamine concentration were severely decreased and that fine motor function was impaired after\n              <jats:styled-content style=\"fixed-case\" toggle=\"no\">ICH<\/jats:styled-content>\n              . Microtubule depolymerization was the main contributor to the loss of dopamine neurons and to motor function deficits after\n              <jats:styled-content style=\"fixed-case\" toggle=\"no\">ICH<\/jats:styled-content>\n              , as was also proven by intrastriatal injection of nocodazole. Moreover, administration of the microtubule stabilizer epothilone B (1.5\u00a0mg\/kg) improved the integrity of the nigrostriatal pathway neural circuit, increased the number of dopamine neurons (4598\u00b1896 versus 3125\u00b1355;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.034) and the dopamine concentration (4.28\u00b10.99\u00a0versus 3.08\u00b10.75\u00a0ng\/mg;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.041), and enhanced fine motor functional recovery associated with increased acetylated \u03b1\u2010tubulin expression to maintain microtubule stabilization after\n              <jats:styled-content style=\"fixed-case\" toggle=\"no\">ICH<\/jats:styled-content>\n              .\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Our results clarified the pathomorphological changes of the nigrostriatal pathway after\n              <jats:styled-content style=\"fixed-case\" toggle=\"no\">ICH<\/jats:styled-content>\n              and found that epothilone B helped alleviate nigrostriatal pathway injury after\n              <jats:styled-content style=\"fixed-case\" toggle=\"no\">ICH<\/jats:styled-content>\n              , associated with promoting \u03b1\u2010tubulin acetylation to maintain microtubule stabilization, thus facilitating motor recovery.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.117.007626","type":"journal-article","created":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T20:20:15Z","timestamp":1516306815000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":38,"title":["Epothilone B Benefits Nigrostriatal Pathway Recovery by Promoting Microtubule Stabilization After Intracerebral Hemorrhage"],"prefix":"10.1161","volume":"7","author":[{"given":"Yang","family":"Yang","sequence":"first","affiliation":[{"name":"Third Military Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Third Military Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongfei","family":"Ge","sequence":"additional","affiliation":[{"name":"Third Military Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Third Military Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eryi","family":"Sun","sequence":"additional","affiliation":[{"name":"Medical University Affiliated Hospital","place":["Guiyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Ma","sequence":"additional","affiliation":[{"name":"Third Military Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengli","family":"Zhao","sequence":"additional","affiliation":[{"name":"Third Military Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongwei","family":"Li","sequence":"additional","affiliation":[{"name":"Third Military Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Third Military Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jichao","family":"Yuan","sequence":"additional","affiliation":[{"name":"Third Military Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianwei","family":"Chen","sequence":"additional","affiliation":[{"name":"Third Military Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Chen","sequence":"additional","affiliation":[{"name":"Third Military Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[{"name":"Third Military Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Loma Linda University","place":["Loma Linda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Hu","sequence":"additional","affiliation":[{"name":"Third Military Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotang","family":"Fan","sequence":"additional","affiliation":[{"name":"Third Military Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Feng","sequence":"additional","affiliation":[{"name":"Third Military Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.pneurobio.2013.09.007","article-title":"Progress in translational research on intracerebral hemorrhage: is there an end in sight?","volume":"115","author":"Xi G","year":"2014","unstructured":"Xi G, Strahle J, Hua Y, Keep RF. Progress in translational research on intracerebral hemorrhage: is there an end in sight? Prog Neurobiol. 2014;115:45\u201363.","journal-title":"Prog Neurobiol"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S0140-6736(16)30962-X","article-title":"Stroke","volume":"389","author":"Hankey GJ","year":"2017","unstructured":"Hankey GJ. Stroke. Lancet. 2017;389:641\u2013654.","journal-title":"Lancet"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/S1474-4422(12)70104-7","article-title":"Intracerebral haemorrhage: mechanisms of injury and therapeutic targets","volume":"11","author":"Keep RF","year":"2012","unstructured":"Keep RF, Hua Y, Xi G. Intracerebral haemorrhage: mechanisms of injury and therapeutic targets. Lancet Neurol. 2012;11:720\u2013731.","journal-title":"Lancet Neurol"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.mehy.2012.09.004","article-title":"The human extrapyramidal system","volume":"79","author":"de Oliveira\u2010Souza R","year":"2012","unstructured":"de Oliveira\u2010Souza R. The human extrapyramidal system. Med Hypotheses. 2012;79:843\u2013852.","journal-title":"Med Hypotheses"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0140-6736(01)05966-9","article-title":"Effect of levodopa in combination with physiotherapy on functional motor recovery after stroke: a prospective, randomised, double\u2010blind study","volume":"358","author":"Scheidtmann K","year":"2001","unstructured":"Scheidtmann K, Fries W, Muller F, Koenig E. Effect of levodopa in combination with physiotherapy on functional motor recovery after stroke: a prospective, randomised, double\u2010blind study. Lancet. 2001;358:787\u2013790.","journal-title":"Lancet"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1016\/j.apmr.2008.02.030","article-title":"Levodopa improves procedural motor learning in chronic stroke patients","volume":"89","author":"Rosser N","year":"2008","unstructured":"Rosser N, Heuschmann P, Wersching H, Breitenstein C, Knecht S, Floel A. Levodopa improves procedural motor learning in chronic stroke patients. Arch Phys Med Rehabil. 2008;89:1633\u20131641.","journal-title":"Arch Phys Med Rehabil"},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1161\/STROKEAHA.111.638767","article-title":"Levodopa treatment improves functional recovery after experimental stroke","volume":"43","author":"Ruscher K","year":"2012","unstructured":"Ruscher K, Kuric E, Wieloch T. Levodopa treatment improves functional recovery after experimental stroke. Stroke. 2012;43:507\u2013513.","journal-title":"Stroke"},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.tins.2010.05.001","article-title":"Tubulin post\u2010translational modifications: encoding functions on the neuronal microtubule cytoskeleton","volume":"33","author":"Janke C","year":"2010","unstructured":"Janke C, Kneussel M. Tubulin post\u2010translational modifications: encoding functions on the neuronal microtubule cytoskeleton. Trends Neurosci. 2010;33:362\u2013372.","journal-title":"Trends Neurosci"},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1177\/1073858406293853","article-title":"Microtubule: a common target for parkin and Parkinson's disease toxins","volume":"12","author":"Feng J","year":"2006","unstructured":"Feng J. Microtubule: a common target for parkin and Parkinson's disease toxins. Neuroscientist. 2006;12:469\u2013476.","journal-title":"Neuroscientist"},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1111\/j.1471-4159.2008.05526.x","article-title":"Intrastriatal injection of colchicine induces striatonigral degeneration in mice","volume":"106","author":"Liang Y","year":"2008","unstructured":"Liang Y, Li S, Wen C, Zhang Y, Guo Q, Wang H, Su B. Intrastriatal injection of colchicine induces striatonigral degeneration in mice. J Neurochem. 2008;106:1815\u20131827.","journal-title":"J Neurochem"},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1126\/science.1201148","article-title":"Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury","volume":"331","author":"Hellal F","year":"2011","unstructured":"Hellal F, Hurtado A, Ruschel J, Flynn KC, Laskowski CJ, Umlauf M, Kapitein LC, Strikis D, Lemmon V, Bixby J, Hoogenraad CC, Bradke F. Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury. Science. 2011;331:928\u2013931.","journal-title":"Science"},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1523\/JNEUROSCI.4885-10.2011","article-title":"Taxol facilitates axon regeneration in the mature CNS","volume":"31","author":"Sengottuvel V","year":"2011","unstructured":"Sengottuvel V, Leibinger M, Pfreimer M, Andreadaki A, Fischer D. Taxol facilitates axon regeneration in the mature CNS. J Neurosci. 2011;31:2688\u20132699.","journal-title":"J Neurosci"},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1126\/science.aaa2958","article-title":"Axonal regeneration. Systemic administration of epothilone B promotes axon regeneration after spinal cord injury","volume":"348","author":"Ruschel J","year":"2015","unstructured":"Ruschel J, Hellal F, Flynn KC, Dupraz S, Elliott DA, Tedeschi A, Bates M, Sliwinski C, Brook G, Dobrindt K, Peitz M, Brustle O, Norenberg MD, Blesch A, Weidner N, Bunge MB, Bixby JL, Bradke F. Axonal regeneration. Systemic administration of epothilone B promotes axon regeneration after spinal cord injury. Science. 2015;348:347\u2013352.","journal-title":"Science"},{"key":"e_1_3_2_15_2","first-page":"e4289","article-title":"Modeling intracerebral hemorrhage in mice: injection of autologous blood or bacterial collagenase","author":"Krafft PR","year":"2012","unstructured":"Krafft PR, Rolland WB, Duris K, Lekic T, Campbell A, Tang J, Zhang JH. Modeling intracerebral hemorrhage in mice: injection of autologous blood or bacterial collagenase. J Vis Exp. 2012:e4289.","journal-title":"J Vis Exp"},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/nprot.2007.513","article-title":"A mouse model of intracerebral hemorrhage using autologous blood infusion","volume":"3","author":"Rynkowski MA","year":"2008","unstructured":"Rynkowski MA, Kim GH, Komotar RJ, Otten ML, Ducruet AF, Zacharia BE, Kellner CP, Hahn DK, Merkow MB, Garrett MC, Starke RM, Cho BM, Sosunov SA, Connolly ES. A mouse model of intracerebral hemorrhage using autologous blood infusion. Nat Protoc. 2008;3:122\u2013128.","journal-title":"Nat Protoc"},{"key":"e_1_3_2_17_2","doi-asserted-by":"crossref","first-page":"9169","DOI":"10.1523\/JNEUROSCI.0612-07.2007","article-title":"Disorganized microtubules underlie the formation of retraction bulbs and the failure of axonal regeneration","volume":"27","author":"Erturk A","year":"2007","unstructured":"Erturk A, Hellal F, Enes J, Bradke F. Disorganized microtubules underlie the formation of retraction bulbs and the failure of axonal regeneration. J Neurosci. 2007;27:9169\u20139180.","journal-title":"J Neurosci"},{"key":"e_1_3_2_18_2","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/s12035-013-8510-y","article-title":"Activation of liver X receptor is protective against ethanol\u2010induced developmental impairment of Bergmann glia and Purkinje neurons in the mouse cerebellum","volume":"49","author":"Yang Y","year":"2014","unstructured":"Yang Y, Tang Y, Xing Y, Zhao M, Bao X, Sun D, Tang X, Wu Y, Xu H, Fan X. Activation of liver X receptor is protective against ethanol\u2010induced developmental impairment of Bergmann glia and Purkinje neurons in the mouse cerebellum. Mol Neurobiol. 2014;49:176\u2013186.","journal-title":"Mol Neurobiol"},{"key":"e_1_3_2_19_2","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/mp.2014.60","article-title":"Liver X receptor beta is essential for the differentiation of radial glial cells to oligodendrocytes in the dorsal cortex","volume":"19","author":"Xu P","year":"2014","unstructured":"Xu P, Xu H, Tang X, Xu L, Wang Y, Guo L, Yang Z, Xing Y, Wu Y, Warner M, Gustafsson JA, Fan X. Liver X receptor beta is essential for the differentiation of radial glial cells to oligodendrocytes in the dorsal cortex. Mol Psychiatry. 2014;19:947\u2013957.","journal-title":"Mol Psychiatry"},{"key":"e_1_3_2_20_2","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.bbr.2014.10.037","article-title":"Amantadine preserves dopamine level and attenuates depression\u2010like behavior induced by traumatic brain injury in rats","volume":"279","author":"Tan L","year":"2015","unstructured":"Tan L, Ge H, Tang J, Fu C, Duanmu W, Chen Y, Hu R, Sui J, Liu X, Feng H. Amantadine preserves dopamine level and attenuates depression\u2010like behavior induced by traumatic brain injury in rats. Behav Brain Res. 2015;279:274\u2013282.","journal-title":"Behav Brain Res"},{"key":"e_1_3_2_21_2","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1038\/sj.jcbfm.9600134","article-title":"Delayed treatment with monoclonal antibody in\u20101 1\u00a0week after stroke results in recovery of function and corticorubral plasticity in adult rats","volume":"25","author":"Seymour AB","year":"2005","unstructured":"Seymour AB, Andrews EM, Tsai SY, Markus TM, Bollnow MR, Brenneman MM, O'Brien TE, Castro AJ, Schwab ME, Kartje GL. Delayed treatment with monoclonal antibody in\u20101 1\u00a0week after stroke results in recovery of function and corticorubral plasticity in adult rats. J Cereb Blood Flow Metab. 2005;25:1366\u20131375.","journal-title":"J Cereb Blood Flow Metab"},{"key":"e_1_3_2_22_2","first-page":"171","volume-title":"Methods of Behavior Analysis in Neuroscience","author":"Curzon P","year":"2009","unstructured":"Curzon P, Zhang M, Radek RJ, Fox GB. Frontiers in neurosciencethe behavioral assessment of sensorimotor processes in the mouse: acoustic startle, sensory gating, locomotor activity, rotarod, and beam walking. In: Buccafusco JJ, ed. Methods of Behavior Analysis in Neuroscience. Boca Raton (FL): CRC Press\/Taylor & Francis Taylor & Francis Group, LLC.; 2009:171\u2013176."},{"key":"e_1_3_2_23_2","first-page":"e1204","article-title":"The ladder rung walking task: a scoring system and its practical application","volume":"28","author":"Metz GA","year":"2009","unstructured":"Metz GA, Whishaw IQ. The ladder rung walking task: a scoring system and its practical application. J Vis Exp. 2009;28:e1204.","journal-title":"J Vis Exp"},{"key":"e_1_3_2_24_2","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1089\/neu.1998.15.599","article-title":"Sustained sensory\/motor and cognitive deficits with neuronal apoptosis following controlled cortical impact brain injury in the mouse","volume":"15","author":"Fox GB","year":"1998","unstructured":"Fox GB, Fan L, Levasseur RA, Faden AI. Sustained sensory\/motor and cognitive deficits with neuronal apoptosis following controlled cortical impact brain injury in the mouse. J Neurotrauma. 1998;15:599\u2013614.","journal-title":"J Neurotrauma"},{"key":"e_1_3_2_25_2","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/nprot.2008.199","article-title":"Primary support cultures of hippocampal and substantia nigra neurons","volume":"4","author":"Fath T","year":"2009","unstructured":"Fath T, Ke YD, Gunning P, Gotz J, Ittner LM. Primary support cultures of hippocampal and substantia nigra neurons. Nat Protoc. 2009;4:78\u201385.","journal-title":"Nat Protoc"},{"key":"e_1_3_2_26_2","doi-asserted-by":"crossref","first-page":"37681","DOI":"10.1038\/srep37681","article-title":"Poly\u2010L\u2010ornithine enhances migration of neural stem\/progenitor cells via promoting alpha\u2010Actinin 4 binding to actin filaments","volume":"6","author":"Ge H","year":"2016","unstructured":"Ge H, Yu A, Chen J, Yuan J, Yin Y, Duanmu W, Tan L, Yang Y, Lan C, Chen W, Feng H, Hu R. Poly\u2010L\u2010ornithine enhances migration of neural stem\/progenitor cells via promoting alpha\u2010Actinin 4 binding to actin filaments. Sci Rep. 2016;6:37681.","journal-title":"Sci Rep"},{"key":"e_1_3_2_27_2","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.nbd.2014.10.016","article-title":"Increased expression of the dopamine transporter leads to loss of dopamine neurons, oxidative stress and l\u2010DOPA reversible motor deficits","volume":"74","author":"Masoud ST","year":"2015","unstructured":"Masoud ST, Vecchio LM, Bergeron Y, Hossain MM, Nguyen LT, Bermejo MK, Kile B, Sotnikova TD, Siesser WB, Gainetdinov RR, Wightman RM, Caron MG, Richardson JR, Miller GW, Ramsey AJ, Cyr M, Salahpour A. Increased expression of the dopamine transporter leads to loss of dopamine neurons, oxidative stress and l\u2010DOPA reversible motor deficits. Neurobiol Dis. 2015;74:66\u201375.","journal-title":"Neurobiol Dis"},{"key":"e_1_3_2_28_2","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1007\/s12035-016-9737-1","article-title":"Liver X receptor beta is involved in formalin\u2010induced spontaneous pain","volume":"54","author":"Bao X","year":"2017","unstructured":"Bao X, Cai Y, Wang Y, Zhao J, He X, Yu D, Huang J, Jing S, Du Z, Yang T, Warner M, Gustafsson JA, Fan X. Liver X receptor beta is involved in formalin\u2010induced spontaneous pain. Mol Neurobiol. 2017;54:1467\u20131481.","journal-title":"Mol Neurobiol"},{"key":"e_1_3_2_29_2","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/0031-9384(95)00103-P","article-title":"Locomotor and passive avoidance deficits following occlusion of the middle cerebral artery","volume":"58","author":"Borlongan CV","year":"1995","unstructured":"Borlongan CV, Cahill DW, Sanberg PR. Locomotor and passive avoidance deficits following occlusion of the middle cerebral artery. Physiol Behav. 1995;58:909\u2013917.","journal-title":"Physiol Behav"},{"key":"e_1_3_2_30_2","doi-asserted-by":"crossref","first-page":"252","DOI":"10.2522\/ptj.20090061","article-title":"Cognitive load and dual\u2010task performance during locomotion poststroke: a feasibility study using a functional virtual environment","volume":"90","author":"Kizony R","year":"2010","unstructured":"Kizony R, Levin MF, Hughey L, Perez C, Fung J. Cognitive load and dual\u2010task performance during locomotion poststroke: a feasibility study using a functional virtual environment. Phys Ther. 2010;90:252\u2013260.","journal-title":"Phys Ther"},{"key":"e_1_3_2_31_2","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1002\/hbm.22072","article-title":"The cortical control of cycling exercise in stroke patients: an fNIRS study","volume":"34","author":"Lin PY","year":"2013","unstructured":"Lin PY, Chen JJ, Lin SI. The cortical control of cycling exercise in stroke patients: an fNIRS study. Hum Brain Mapp. 2013;34:2381\u20132390.","journal-title":"Hum Brain Mapp"},{"key":"e_1_3_2_32_2","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.tcb.2017.02.005","article-title":"Moonlighting motors: kinesin, dynein, and cell polarity","volume":"7","author":"Lu W","year":"2017","unstructured":"Lu W, Gelfand VI. Moonlighting motors: kinesin, dynein, and cell polarity. Trends Cell Biol. 2017;7:505\u2013514.","journal-title":"Trends Cell Biol"},{"key":"e_1_3_2_33_2","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nrn3176","article-title":"Assembly of a new growth cone after axotomy: the precursor to axon regeneration","volume":"13","author":"Bradke F","year":"2012","unstructured":"Bradke F, Fawcett JW, Spira ME. Assembly of a new growth cone after axotomy: the precursor to axon regeneration. Nat Rev Neurosci. 2012;13:183\u2013193.","journal-title":"Nat Rev Neurosci"},{"key":"e_1_3_2_34_2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1177\/1073858415616558","article-title":"LRRK2 at the crossroad between autophagy and microtubule trafficking: insights into Parkinson's disease","volume":"23","author":"Esteves AR","year":"2016","unstructured":"Esteves AR, Cardoso SM. LRRK2 at the crossroad between autophagy and microtubule trafficking: insights into Parkinson's disease. Neuroscientist. 2016;23:16\u201326.","journal-title":"Neuroscientist"},{"key":"e_1_3_2_35_2","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.tcb.2014.10.004","article-title":"Post\u2010translational modifications of tubulin: pathways to functional diversity of microtubules","volume":"25","author":"Song Y","year":"2015","unstructured":"Song Y, Brady ST. Post\u2010translational modifications of tubulin: pathways to functional diversity of microtubules. Trends Cell Biol. 2015;25:125\u2013136.","journal-title":"Trends Cell Biol"},{"key":"e_1_3_2_36_2","doi-asserted-by":"crossref","first-page":"21517","DOI":"10.1073\/pnas.1013728107","article-title":"The major alpha\u2010tubulin K40 acetyltransferase alphaTAT1 promotes rapid ciliogenesis and efficient mechanosensation","volume":"107","author":"Shida T","year":"2010","unstructured":"Shida T, Cueva JG, Xu Z, Goodman MB, Nachury MV. The major alpha\u2010tubulin K40 acetyltransferase alphaTAT1 promotes rapid ciliogenesis and efficient mechanosensation. Proc Natl Acad Sci USA. 2010;107:21517\u201321522.","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_2_37_2","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/nature09324","article-title":"MEC\u201017 is an alpha\u2010tubulin acetyltransferase","volume":"467","author":"Akella JS","year":"2010","unstructured":"Akella JS, Wloga D, Kim J, Starostina NG, Lyons\u2010Abbott S, Morrissette NS, Dougan ST, Kipreos ET, Gaertig J. MEC\u201017 is an alpha\u2010tubulin acetyltransferase. Nature. 2010;467:218\u2013222.","journal-title":"Nature"},{"key":"e_1_3_2_38_2","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.celrep.2013.12.004","article-title":"Loss of MEC\u201017 leads to microtubule instability and axonal degeneration","volume":"6","author":"Neumann B","year":"2014","unstructured":"Neumann B, Hilliard MA. Loss of MEC\u201017 leads to microtubule instability and axonal degeneration. Cell Rep. 2014;6:93\u2013103.","journal-title":"Cell Rep"},{"key":"e_1_3_2_39_2","doi-asserted-by":"crossref","first-page":"12673","DOI":"10.1523\/JNEUROSCI.0016-12.2012","article-title":"MEC\u201017 deficiency leads to\u00a0reduced alpha\u2010tubulin acetylation and impaired migration of cortical neurons","volume":"32","author":"Li L","year":"2012","unstructured":"Li L, Wei D, Wang Q, Pan J, Liu R, Zhang X, Bao L. MEC\u201017 deficiency leads to\u00a0reduced alpha\u2010tubulin acetylation and impaired migration of cortical neurons. J Neurosci. 2012;32:12673\u201312683.","journal-title":"J Neurosci"}],"updated-by":[{"DOI":"10.1161\/jaha.125.045055","type":"expression_of_concern","label":"Expression of concern","source":"publisher","updated":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000}}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.117.007626","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T14:45:24Z","timestamp":1760453124000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.117.007626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,23]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,1,23]]}},"alternative-id":["10.1161\/JAHA.117.007626"],"URL":"https:\/\/doi.org\/10.1161\/jaha.117.007626","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,23]]},"assertion":[{"value":"2017-11-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-12-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e007626"}}