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A common challenge in this field is the impact of cancer drugs on cardiac repolarization (ie,\n                      <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>\n                      prolongation) and the potential risk for the life\u2010threatening arrhythmia torsades de pointes. Although\n                      <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>\n                      prolongation is not a perfect marker of arrhythmia risk, this has become a primary safety metric among oncologists. Cardiologists caring for patients receiving cancer treatment should become familiar with the drugs associated with\n                      <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>\n                      prolongation, its incidence, and appropriate management strategies to provide meaningful consultation in this complex clinical scenario.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      In this article, we performed a systematic review (using Preferred Reporting Items of Systematic Reviews and Meta\u2010Analyses (PRISMA) guidelines) of commonly used cancer drugs to determine the incidence of\n                      <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>\n                      prolongation and clinically relevant arrhythmias. We calculated summary estimates of the incidence of all and clinically relevant\n                      <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>\n                      prolongation as well as arrhythmias and sudden cardiac death. We then describe strategies to prevent, identify, and manage\n                      <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>\n                      prolongation in patients receiving cancer therapy. We identified a total of 173 relevant publications. The weighted incidence of any corrected\n                      <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>\n                      (\n                      <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>\n                      c) prolongation in our systematic review in patients treated with conventional therapies (eg, anthracyclines) ranged from 0% to 22%, although\n                      <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>\n                      c &gt;500\u00a0ms, arrhythmias, or sudden cardiac death was extremely rare. The risk of\n                      <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>\n                      c prolongation with targeted therapies (eg, small molecular tyrosine kinase inhibitors) ranged between 0% and 22.7% with severe prolongation (\n                      <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>\n                      c &gt;500\u00a0ms) reported in 0% to 5.2% of the patients. Arrhythmias and sudden cardiac death were rare.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Our systematic review demonstrates that there is variability in the incidence of\n                      <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>\n                      c prolongation of various cancer drugs; however, the clinical consequence, as defined by arrhythmias or sudden cardiac death, remains rare.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.117.007724","type":"journal-article","created":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T20:10:36Z","timestamp":1512677436000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":189,"title":["Incidence, Diagnosis, and Management of QT Prolongation Induced by Cancer Therapies: A Systematic Review"],"prefix":"10.1161","volume":"6","author":[{"given":"Andreu","family":"Porta\u2010S\u00e1nchez","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Electrophysiology, Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Electrophysiology, Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danna","family":"Spears","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Electrophysiology, Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eitan","family":"Amir","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University Health Network, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumaraswamy","family":"Nanthakumar","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Electrophysiology, Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paaladinesh","family":"Thavendiranathan","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Peter Munk Cardiac Centre, Ted Rogers Program in Cardiotoxicity Prevention and Department of Medical Imaging, University Health Network University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31012-1"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.57.6.1074"},{"key":"e_1_3_3_4_2","first-page":"e123","article-title":"Preferred reporting items for systematic reviews and meta\u2010analyses: the PRISMA statement","volume":"3","author":"Moher D","year":"2009","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG; Group P . 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