{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T06:57:22Z","timestamp":1793948242525,"version":"4.8.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,1,23]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Preterm birth has been associated with increased risk of cardiovascular morbidity in adult life. We evaluated whether preterm birth is associated with deviating cardiac structure and function before school start.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      In total, 176 children aged 6 years and born extremely preterm (\n                      <jats:styled-content style=\"fixed-case\" toggle=\"no\">EXPT<\/jats:styled-content>\n                      ; gestational age of 22\u201326\u00a0weeks) and 134 children born at term (control [\n                      <jats:styled-content style=\"fixed-case\" toggle=\"no\">CTRL<\/jats:styled-content>\n                      ]) were studied. We used echocardiography to assess left heart dimensions, geometry, and functions. Recording and off\u2010line analyses of echocardiographic images were performed by operators blinded to group belonging. Body size, blood pressure, and heart rate were also measured. Rates of family history of cardiovascular disease and sex distribution were similar in the\n                      <jats:styled-content style=\"fixed-case\" toggle=\"no\">EXPT<\/jats:styled-content>\n                      and CTRL groups. Heart rate and systolic blood pressure did not differ, whereas diastolic blood pressure was slightly higher in\n                      <jats:styled-content style=\"fixed-case\" toggle=\"no\">EXPT<\/jats:styled-content>\n                      than CTRL participants. After adjusting for body surface area, left ventricular length, width, and aortic valve annulus diameter were 3% to 5% smaller in\n                      <jats:styled-content style=\"fixed-case\" toggle=\"no\">EXPT<\/jats:styled-content>\n                      than CTRL participants. Left ventricular longitudinal shortening and systolic tissue velocity were 7% to 11% lower, and transversal shortening fraction was 6% higher in\n                      <jats:styled-content style=\"fixed-case\" toggle=\"no\">EXPT<\/jats:styled-content>\n                      than CTRL participants. The\n                      <jats:styled-content style=\"fixed-case\" toggle=\"no\">EXPT<\/jats:styled-content>\n                      group also exhibited lower atrial emptying velocities than the CTRL group. Sex, fetal growth restriction, or a patent ductus arteriosus in the neonatal period did not contribute to cardiac dimensions or performance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Six\u2010year\u2010old children born extremely preterm exhibit a unique cardiac phenotype characterized by smaller left ventricles with altered systolic and diastolic functions than same\u2010aged children born at term.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.117.007742","type":"journal-article","created":{"date-parts":[[2018,1,20]],"date-time":"2018-01-20T20:10:29Z","timestamp":1516479029000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":67,"title":["The Preterm Heart in Childhood: Left Ventricular Structure, Geometry, and Function Assessed by Echocardiography in 6\u2010Year\u2010Old Survivors of Periviable Births"],"prefix":"10.1161","volume":"7","author":[{"given":"Lilly\u2010Ann","family":"Mohlkert","sequence":"first","affiliation":[{"name":"Karolinska Institutet","place":["Stockholm, Sweden"]},{"name":"S\u00f6dersjukhuset","place":["Stockholm, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Hallberg","sequence":"additional","affiliation":[{"name":"Karolinska Institutet","place":["Stockholm, Sweden"]},{"name":"S\u00f6dersjukhuset","place":["Stockholm, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olof","family":"Broberg","sequence":"additional","affiliation":[{"name":"Lund University","place":["Lund, Sweden"]},{"name":"Sk\u00e5ne University Hospital","place":["Lund, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Rydberg","sequence":"additional","affiliation":[{"name":"Ume\u00e5 University","place":["Ume\u00e5, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia Pegelow","family":"Halvorsen","sequence":"additional","affiliation":[{"name":"Karolinska Institutet","place":["Stockholm, Sweden"]},{"name":"S\u00f6dersjukhuset","place":["Stockholm, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petru","family":"Liuba","sequence":"additional","affiliation":[{"name":"Lund University","place":["Lund, Sweden"]},{"name":"Sk\u00e5ne University Hospital","place":["Lund, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vineta","family":"Fellman","sequence":"additional","affiliation":[{"name":"University of Helsinki","place":["Helsinki, Finland"]},{"name":"Lund University","place":["Lund, Sweden"]},{"name":"Sk\u00e5ne University Hospital","place":["Lund, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Domell\u00f6f","sequence":"additional","affiliation":[{"name":"Ume\u00e5 University","place":["Ume\u00e5, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Sj\u00f6berg","sequence":"additional","affiliation":[{"name":"Karolinska Institutet","place":["Stockholm, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Norman","sequence":"additional","affiliation":[{"name":"Karolinska Institutet","place":["Stockholm, Sweden"]},{"name":"Karolinska University Hospital","place":["Stockholm, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1161\/HYPERTENSIONAHA.111.181784","article-title":"Systematic review and meta\u2010analysis of preterm birth and later systolic blood pressure","volume":"59","author":"de Jong F","year":"2012","unstructured":"de Jong F, Monuteaux MC, van Elburg RM, Gillman MW, Belfort MB. 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