{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:08:34Z","timestamp":1783728514718,"version":"3.55.0"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,1,9]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The impact of serum matrix metalloproteinases\u20109 (MMP\u20109) on cognitive impairment after ischemic stroke is unclear. We aimed to investigate the association between serum MMP\u20109 in the short\u2010term acute phase of ischemic stroke and cognitive impairment at 3\u00a0months.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Our study was based on a subsample from the CATIS (China Antihypertensive Trial in Acute Ischemic Stroke); a total of 558 patients with serum MMP\u20109 levels from 7 of 26 participating sites of the trial were included in this analysis. Cognitive impairment severity was categorized as severe, mild, or none (Mini\u2010Mental State Examination score, &lt;23, 23\u201326, or \u226527, respectively; Montreal Cognitive Assessment score, &lt;20, 20\u201324, or \u226525, respectively). Cognitive impairment was defined as a score of &lt;27 for Mini\u2010Mental State Examination or &lt;25 for Montreal Cognitive Assessment. According to Mini\u2010Mental State Examination score, 143 participants (25.6%) had mild cognitive impairment and 153 (27.4%) had severe cognitive impairment at 3\u00a0months. After adjustment for age, National Institutes of Health stroke score, education, and other covariates, the odds ratio for the highest quartile of serum MMP\u20109 compared with the lowest quartile was 3.20 (95% confidence interval, 1.87\u20135.49) for cognitive impairment. Multiple\u2010adjusted spline regression model showed a linear association between MMP\u20109 levels and cognitive impairment (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001 for linearity). Sensitivity and subgroup analyses further confirmed these results. Similar significant findings were observed when cognitive impairment was defined by Montreal Cognitive Assessment score.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Increased serum MMP\u20109 levels in the short\u2010term phase of ischemic stroke were associated with 3\u2010month cognitive impairment, independently of established risk factors.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.117.007776","type":"journal-article","created":{"date-parts":[[2018,1,7]],"date-time":"2018-01-07T01:10:16Z","timestamp":1515287416000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":55,"title":["Serum Matrix Metalloproteinase\u20109 and Cognitive Impairment After Acute Ischemic Stroke"],"prefix":"10.1161","volume":"7","author":[{"given":"Chongke","family":"Zhong","sequence":"first","affiliation":[{"name":"Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China"},{"name":"Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Bu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China"},{"name":"Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libing","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Siping Central Hospital, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Jilin Central Hospital, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jintao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The 88th Hospital of PLA, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Neurology, General Hospital of First Automobile Works, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Feicheng City People's Hospital, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tongliao Municipal Hospital, Inner Mongolia, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kerqin District First People's Hospital of Tongliao City, Inner Mongolia, 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