{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:11:31Z","timestamp":1791288691113,"version":"4.3.0"},"reference-count":95,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,7,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The natural course of abdominal aortic aneurysms (\n              <jats:styled-content style=\"fixed-case\">AAA<\/jats:styled-content>\n              ) is growth and rupture if left untreated. Numerous markers have been investigated; however, none are broadly acknowledged. Our aim was to identify potential prognostic markers for\n              <jats:styled-content style=\"fixed-case\">AAA<\/jats:styled-content>\n              growth and rupture.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Potential circulating, biomechanical, and genetic markers were studied. A comprehensive search was conducted in PubMed, Embase, and Cochrane Library in February 2017, following Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses (PRISMA) guidelines. Study selection, data extraction, and methodological quality assessment were conducted by 2 independent researchers. Plausibility of markers was based on the amount of publications regarding the marker (more than 3), pooled sample size (more than 100), bias risk and statistical significance of the studies. Eighty\u2010two studies were included, which examined circulating (n=40), biomechanical (n=27), and genetic markers (n=7) and combinations of markers (n=8). Factors with an increased expansion risk included:\n              <jats:styled-content style=\"fixed-case\">AAA<\/jats:styled-content>\n              diameter (9 studies; n=1938; low bias risk), chlamydophila pneumonia (4 studies; n=311; medium bias risk), S\u2010elastin peptides (3 studies; n=205; medium bias risk), fluorodeoxyglucose uptake (3 studies; n=104; medium bias risk), and intraluminal thrombus size (5 studies; n=758; medium bias risk). Factors with an increased rupture risk rupture included: peak wall stress (9 studies; n=579; medium bias risk) and\n              <jats:styled-content style=\"fixed-case\">AAA<\/jats:styled-content>\n              diameter (8 studies; n=354; medium bias risk). No meta\u2010analysis was conducted because of clinical and methodological heterogeneity.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We identified 5 potential markers with a prognostic value for\n              <jats:styled-content style=\"fixed-case\">AAA<\/jats:styled-content>\n              growth and 2 for rupture. While interpreting these data, one must realize that conclusions are based on small sample sizes and clinical and methodological heterogeneity. Prospective and methodological consonant studies are strongly urged to further study these potential markers.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.117.007791","type":"journal-article","created":{"date-parts":[[2018,6,30]],"date-time":"2018-06-30T09:15:10Z","timestamp":1530350110000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":57,"title":["Systematic Review of Circulating, Biomechanical, and Genetic Markers for the Prediction of Abdominal Aortic Aneurysm Growth and Rupture"],"prefix":"10.1161","volume":"7","author":[{"given":"Menno E.","family":"Groeneveld","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery Amsterdam Cardiovascular Sciences (ACS) VU University Medical Center (VUmc) Amsterdam The Netherlands"},{"name":"Department of Physiology Amsterdam Cardiovascular Sciences (ACS) VU University Medical Center (VUmc) Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorn P.","family":"Meekel","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Amsterdam Cardiovascular Sciences (ACS) VU University Medical Center (VUmc) Amsterdam The Netherlands"},{"name":"Department of Physiology Amsterdam Cardiovascular Sciences (ACS) VU University Medical Center (VUmc) Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidney M.","family":"Rubinstein","sequence":"additional","affiliation":[{"name":"Department of Health Sciences and Amsterdam Public Health research institute VU University Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisanne R.","family":"Merkestein","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Amsterdam Cardiovascular Sciences (ACS) VU University Medical Center (VUmc) Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert Jan","family":"Tangelder","sequence":"additional","affiliation":[{"name":"Department of Physiology Amsterdam Cardiovascular Sciences (ACS) VU University Medical Center (VUmc) Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem","family":"Wisselink","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Amsterdam Cardiovascular Sciences (ACS) VU University Medical Center (VUmc) Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"Truijers","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Amsterdam Cardiovascular Sciences (ACS) VU University Medical Center (VUmc) Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kak Khee","family":"Yeung","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Amsterdam Cardiovascular Sciences (ACS) VU University Medical Center (VUmc) Amsterdam The Netherlands"},{"name":"Department of Physiology Amsterdam Cardiovascular Sciences (ACS) VU University Medical Center (VUmc) Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1586\/14779072.2015.1074861"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2009.07.001"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2010.09.011"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2010.02.007"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-144-6-200603210-00010"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1037\/1082-989X.6.2.161"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/ejvs.2001.1329"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(97)70222-2"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/ejvs.2000.1151"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.1999.01126.x"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2001.115816"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1053\/ejvs.2002.1872"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-006-0245-5"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/1538574407301429"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2008.04.017"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2012.01.003"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2009.12.021"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000138746.14425.00"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.03.016"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/0003319709344190"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(02)00006-0"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-007-9014-6"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(99)70049-2"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1078-5884(03)00177-1"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq171"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2002.121755"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02791.x"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2006.10.022"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2000.178"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.18.2260"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1177\/1538574410361971"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2009.08.075"},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2007.12.004"},{"key":"e_1_3_1_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2007.05.057"},{"key":"e_1_3_1_37_2","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2001.119040"},{"key":"e_1_3_1_38_2","doi-asserted-by":"publisher","DOI":"10.1053\/ejvs.2001.1516"},{"key":"e_1_3_1_39_2","doi-asserted-by":"publisher","DOI":"10.1053\/ejvs.2001.1404"},{"key":"e_1_3_1_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2008.11.014"},{"key":"e_1_3_1_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2011.07.019"},{"key":"e_1_3_1_42_2","first-page":"64","article-title":"Plasma and tissue levels of collagen types I and III markers in patients with abdominal aortic aneurysms","volume":"19","author":"Treska V","year":"2000","unstructured":"Treska V, Topolcan O. Plasma and tissue levels of collagen types I and III markers in patients with abdominal aortic aneurysms. Int Angiol. 2000;19:64\u201368.","journal-title":"Int Angiol"},{"key":"e_1_3_1_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/27.6.949"},{"key":"e_1_3_1_44_2","first-page":"306","article-title":"Plasma glycosylphosphatidylinositol phospholipase D (GPI\u2010PLD) and abdominal aortic aneurysm","volume":"5","author":"Lindqvist M","year":"2012","unstructured":"Lindqvist M, Wallinder J, Bergstr\u00f6m J, Henriksson AE. Plasma glycosylphosphatidylinositol phospholipase D (GPI\u2010PLD) and abdominal aortic aneurysm. Int J Clin Exp Med. 2012;5:306\u2013309.","journal-title":"Int J Clin Exp Med"},{"key":"e_1_3_1_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21022"},{"key":"e_1_3_1_46_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365540701642153"},{"key":"e_1_3_1_47_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.3.296"},{"key":"e_1_3_1_48_2","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2003.74"},{"key":"e_1_3_1_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.11.023"},{"key":"e_1_3_1_50_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.464727"},{"key":"e_1_3_1_51_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.214429"},{"key":"e_1_3_1_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2010.11.009"},{"key":"e_1_3_1_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2014.02.025"},{"key":"e_1_3_1_54_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0007-1323.2001.01911.x"},{"key":"e_1_3_1_55_2","doi-asserted-by":"publisher","DOI":"10.1053\/ejvs.1998.0800"},{"key":"e_1_3_1_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2011.07.013"},{"key":"e_1_3_1_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0967-2109(98)00041-6"},{"key":"e_1_3_1_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2014.05.014"},{"key":"e_1_3_1_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2014.12.009"},{"key":"e_1_3_1_60_2","doi-asserted-by":"publisher","DOI":"10.1053\/ejvs.2000.1262"},{"key":"e_1_3_1_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2014.11.010"},{"key":"e_1_3_1_62_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-010-0067-6"},{"key":"e_1_3_1_63_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1383.046"},{"key":"e_1_3_1_64_2","first-page":"168","article-title":"A comparative study of aortic wall stress using finite element analysis for ruptured and non\u2010ruptured abdominal aortic aneurysms","volume":"28","author":"Venkatasubramaniam AK","year":"2004","unstructured":"Venkatasubramaniam AK, Fagan MJ, Mehta T, Mylankal KJ, Ray B, Kuhan G, Chetter IC, McCollum PT. A comparative study of aortic wall stress using finite element analysis for ruptured and non\u2010ruptured abdominal aortic aneurysms. Eur J Vasc Endovasc Surg. 2004;28:168\u2013176.","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"e_1_3_1_65_2","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2003.213"},{"key":"e_1_3_1_66_2","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2003.40"},{"key":"e_1_3_1_67_2","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2002.125478"},{"key":"e_1_3_1_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.01.001"},{"key":"e_1_3_1_69_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-011-1799-8"},{"key":"e_1_3_1_70_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.114.146415"},{"key":"e_1_3_1_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2008.03.059"},{"key":"e_1_3_1_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2014.03.018"},{"key":"e_1_3_1_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2006.10.009"},{"key":"e_1_3_1_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2007.09.002"},{"key":"e_1_3_1_75_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-008-9490-3"},{"key":"e_1_3_1_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2013.12.018"},{"key":"e_1_3_1_77_2","doi-asserted-by":"publisher","DOI":"10.1053\/ejvs.2000.1217"},{"key":"e_1_3_1_78_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.6779"},{"key":"e_1_3_1_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2004.02.025"},{"key":"e_1_3_1_80_2","doi-asserted-by":"publisher","DOI":"10.1177\/1526602815584018"},{"key":"e_1_3_1_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2004.08.014"},{"key":"e_1_3_1_82_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2000.01486.x"},{"key":"e_1_3_1_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2014.03.274"},{"key":"e_1_3_1_84_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4364"},{"key":"e_1_3_1_85_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000255560.49503.4e"},{"key":"e_1_3_1_86_2","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2008.196"},{"key":"e_1_3_1_87_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2016.11.007"},{"key":"e_1_3_1_88_2","doi-asserted-by":"publisher","DOI":"10.1053\/ejvs.1998.0757"},{"key":"e_1_3_1_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2010.09.011"},{"key":"e_1_3_1_90_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.112.115873"},{"key":"e_1_3_1_91_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1383.044"},{"key":"e_1_3_1_92_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2014.10.092"},{"key":"e_1_3_1_93_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.004918"},{"key":"e_1_3_1_94_2","first-page":"1993","volume-title":"Marfan Syndrome","author":"Dietz HC","year":"2001","unstructured":"Dietz HC. Marfan syndrome. In: Pagon RA, Adam MP, Ardinger HH, Stephanie E Wallace. Marfan Syndrome. GeneReviews\u00ae [Internet]. Seattle (WA): University of Washington, Seattle; 2001:1993\u20132017."},{"key":"e_1_3_1_95_2","doi-asserted-by":"publisher","DOI":"10.1097\/CRD.0b013e3182342316"},{"key":"e_1_3_1_96_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.17.11.2843"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.117.007791","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:24:47Z","timestamp":1715599487000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.117.007791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,3]]},"references-count":95,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2018,7,3]]}},"alternative-id":["10.1161\/JAHA.117.007791"],"URL":"https:\/\/doi.org\/10.1161\/jaha.117.007791","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,3]]},"assertion":[{"value":"2018-01-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e007791"}}