{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:35:14Z","timestamp":1790523314834,"version":"4.1.0"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,1,23]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Recent trends of hospitalizations and in\u2010hospital mortality are not well defined in sarcoidosis. We examined aforementioned trends and prevalence of cardiovascular manifestations and explored rates of implantable cardioverter\u2010defibrillator implantation in hospitalizations with sarcoidosis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Using data from the National Inpatient Sample, a retrospective population cohort from 2005 to 2014 was studied. To identify sarcoidosis, an\n              <jats:italic toggle=\"yes\">International Classification of Diseases, Ninth Revision, Clinical Modification<\/jats:italic>\n              (\n              <jats:italic toggle=\"yes\">ICD\u20109\u2010CM<\/jats:italic>\n              ) diagnosis code was used. We excluded hospitalizations with myocardial infarction, coronary artery disease, and ischemic cardiomyopathy. Cardiovascular manifestations were defined by the presence of diagnosis codes for conduction disorders, arrhythmias, heart failure, nonischemic cardiomyopathy, and pulmonary hypertension. A total of 609\u00a0051 sarcoidosis hospitalizations were identified, with an age of 55\u00b114\u00a0years, 67% women, and 50% black. The number of sarcoidosis hospitalizations increased from 2005 through 2014 (138 versus 175 per 100\u00a0000,\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              <jats:sub>trend<\/jats:sub>\n              &lt;0.001). We observed declining trends of unadjusted in\u2010hospital mortality (6.5 to 4.9 per 100 sarcoidosis hospitalizations,\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              <jats:sub>trend<\/jats:sub>\n              &lt;0.001). Overall \u224831% (n=188\u00a0438) of sarcoidosis hospitalizations had coexistent cardiovascular manifestations of one or more type. Heart failure (\u224816%) and arrhythmias (\u224815%) were the most prevalent cardiovascular manifestations. Rates of implantable cardioverter\u2010defibrillator placement were \u22487.5 per 1000 sarcoidosis hospitalizations (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              <jats:sub>trend<\/jats:sub>\n              =0.95) during the study period. Black race was associated with 21% increased risk of in\u2010hospital mortality (odds ratio, 1.21; 95% confidence interval, 1.16\u20131.27 [\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.001]).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Sarcoidosis hospitalizations have increased over the past decade with a myriad of coexistent cardiovascular manifestations. Black race is a significant predictor of in\u2010hospital mortality, which is declining. Further efforts are needed to improve care in view of low implantable cardioverter\u2010defibrillator rates in sarcoidosis.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.117.007844","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T20:10:55Z","timestamp":1516651855000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":70,"title":["Hospitalization Rates, Prevalence of Cardiovascular Manifestations, and Outcomes Associated With Sarcoidosis in the United States"],"prefix":"10.1161","volume":"7","author":[{"given":"Nirav","family":"Patel","sequence":"first","affiliation":[{"name":"University of Alabama at Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajat","family":"Kalra","sequence":"additional","affiliation":[{"name":"University of Minnesota","place":["Minneapolis"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajkumar","family":"Doshi","sequence":"additional","affiliation":[{"name":"Northwell Health","place":["Manhasset"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harpreet","family":"Arora","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navkaranbir S.","family":"Bajaj","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham"},{"name":"Brigham and Women's Hospital and Harvard Medical School","place":["Boston"]},{"name":"Brigham and Women's Hospital and Harvard Medical School","place":["Boston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garima","family":"Arora","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Arora","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham"},{"name":"Birmingham Veterans Affairs Medical Center","place":["Birmingham"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1055\/s-2007-970332","article-title":"Pathology of sarcoidosis","volume":"28","author":"Rosen Y","year":"2007","unstructured":"Rosen Y. 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