{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T18:59:05Z","timestamp":1785869945228,"version":"3.56.0"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,6,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The incidence of abdominal aortic aneurysms (\n              <jats:styled-content style=\"fixed-case\">AAA<\/jats:styled-content>\n              s) will significantly increase during the next decade. Novel biomarkers, besides diameter, are needed for a better characterization of aneurysms and the estimation of the risk of rupture. Fibrin is a key protein in the formation of focal hematoma associated with the dissection of the aortic wall and the development of larger thrombi during the progression of\n              <jats:styled-content style=\"fixed-case\">AAA<\/jats:styled-content>\n              s. This study evaluated the potential of a fibrin\u2010specific magnetic resonance (MR) probe for the in\u00a0vivo characterization of the different stages of\n              <jats:styled-content style=\"fixed-case\">AAA<\/jats:styled-content>\n              s.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              <jats:styled-content style=\"fixed-case\">AAA<\/jats:styled-content>\n              s spontaneously developed in ApoE\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              mice following the infusion of angiotensin\u2010\n              <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\n              (Ang\u2010\n              <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\n              , 1 \u03bcg\/kg\n              <jats:sup>\u22121<\/jats:sup>\n              \u00b7per minute). An established fibrin\u2010specific molecular\n              <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>\n              probe (\n              <jats:styled-content style=\"fixed-case\">EP<\/jats:styled-content>\n              2104R, 10 \u03bcmol\/kg\n              <jats:sup>\u22121<\/jats:sup>\n              ) was administered after 1 to 4 weeks following Ang\u2010\n              <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\n              infusion (n=8 per group). All imaging experiments were performed on a clinical 3T Achieva\n              <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>\n              system with a microscopy coil (Philips Healthcare, Netherlands). The development of\n              <jats:styled-content style=\"fixed-case\">AAA<\/jats:styled-content>\n              \u2010associated fibrin\u2010rich hematoma and thrombi was assessed. The high signal generated by the fibrin probe enabled high\u2010resolution\n              <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>\n              imaging for an accurate assessment and quantification of the relative fibrin composition of focal hematoma and thrombi. Contrast\u2010to\u2010noise\u2010ratios (\n              <jats:styled-content style=\"fixed-case\">CNRs<\/jats:styled-content>\n              ) and R1\u2010relaxation rates following the administration of the fibrin probe were in good agreement with ex\u00a0vivo immunohistomorphometry (\n              <jats:italic>R<\/jats:italic>\n              <jats:sup>2<\/jats:sup>\n              =0.83 and 0.85) and gadolinium concentrations determined by inductively coupled plasma mass spectroscopy (\n              <jats:italic>R<\/jats:italic>\n              <jats:sup>2<\/jats:sup>\n              =0.78 and 0.72).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The fibrin\u2010specific molecular\n              <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>\n              probe allowed the delineation and quantification of changes in fibrin content in early and advanced\n              <jats:styled-content style=\"fixed-case\">AAA<\/jats:styled-content>\n              s. Fibrin\n              <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n              could provide a novel in\u00a0vivo biomarker to improve the risk stratification of patients with aortic aneurysms.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.117.007909","type":"journal-article","created":{"date-parts":[[2018,5,30]],"date-time":"2018-05-30T09:20:05Z","timestamp":1527672005000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["In Vivo Molecular Characterization of Abdominal Aortic Aneurysms Using Fibrin\u2010Specific Magnetic Resonance Imaging"],"prefix":"10.1161","volume":"7","author":[{"given":"Ren\u00e9 M.","family":"Botnar","sequence":"first","affiliation":[{"name":"Division of Imaging Sciences, King's College London, London, United Kingdom"},{"name":"BHF Centre of Excellence, King's College London, London, United Kingdom"},{"name":"Wellcome Trust and EPSRC Medical Engineering Center, King's College London, London, United Kingdom"},{"name":"NIHR Biomedical Research Centre, King's College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Brangsch","sequence":"additional","affiliation":[{"name":"Department of Radiology, Charite, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolin","family":"Reimann","sequence":"additional","affiliation":[{"name":"Department of Radiology, Charite, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian H. 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